Two groups of clients in a transitional residential program, designated as completers and noncompleters, were compared to evaluate program effectiveness. Clinical records of 228 former clients were examined for demographics, needs on admission, participation in activities, length of stay, psychiatric diagnosis, and type of discharge. This program discharged 48% (110) of the residents according to the contract established on admission. Mean length of stay for program completers was 143 days; length of stay varied for noncompleters. Subjects who completed the program were more likely to obtain permanent housing than noncompleters. Participation in at least two activities while in residence was significantly related to program completion. Type of discharge or length of stay did not vary significantly by Axis 1 psychiatric diagnosis, including chemical dependence, or gender.

Adult↗

PubMedDate not supplied

Erythrocyte formimino glutamate transferase in FIGLU aciduria.

A patient is described who presented at an early age with failure to thrive and vomiting, and had a gross excretion of formimino glutamic acid. She had normal concentration of serum folate and vitamin B12, and no haematological abnormalities, and is not mentally retarded. The Michaelis constant for erythrocyte formimino glutamate transferase was in the normal range, but the enzyme behaves differently from that from reference subjects with respect to inhibitors and activators.

Amino Acid Metabolism, Inborn Errors↗

PubMedDate not supplied

[Prenatal diagnosis of congenital diseases by means of the biochemical study of the amniotic fluid obtained in the 16th week of pregnancy].

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Adult↗

PubMedDate not supplied

[Non-ketotic hypoglycemia caused by carnitine palmitoyl transferase 1 deficiency].

A 9-year-old girl was referred to our hospital after recurrent episodes of hypoglycemia, altered consciousness and persistent vomiting without acetonemia or myopathic symptoms. Other pertinent laboratory data included elevated BUN, hyperammonemia and very low levels of triglycerides with elevated free fatty acids. The patient was born from unaffected but related parents (second cousins) and the illness was previously diagnosed as Reye encephalopathy. Recurrence of similar attacks suggested an underlying metabolic disorder. Several syndromes of impaired FFA beta oxidation were taken into account and discarded successively after laboratory investigations: systemic carnitine deficiency, Medium and Long Chain Acyl-CoA Dehydrogenase deficiency and Multiple Acyl CoA Dehydrogenation deficiency (Glutaric aciduria, Ethylmalonic-adipic aciduria and riboflavin-responsive multiple acyl CoA dehydrogenation deficiency). Urinary and hematic gas-chromatography and Mass-Spectrometry show no abnormality in Medium Chain fatty acids and in C6-C10 dicarboxylic acids. Carnitine plasma concentrations (both total and free) were above normal levels while in urine acetyl carnitine was low in respect to longer acyclic radicals. Among metabolic defects located at the level of hepatic fatty acid oxidation, only Carnitine Transferase deficiency can explain this peculiar mosaic of data (precursors of the blocked reaction are elevated in blood whereas lack of the metabolites derived uniquely from this reaction explains all the clinical manifestations).

Carnitine O-Palmitoyltransferase↗