Search PubMed⌕ Search

Biomedical subjects

M Langer

Publications and source records attributed to M Langer.

At least 451 records · Page 25Linked to original sources
PubMed1981

Radiologic analysis of bone structure in congenital angiodysplasia.

47 patients with congenital arteriovenous malformations (AVM) were examined by routine radiography. Magnification films were performed in 20 cases. The results demonstrate that different types of AVM can be successfully differentiated by non-invasive radiologic techniques. The F.P. Weber type AVM is characterized by destruction of the regular trabecular bone architecture in the areas of the AV-shunts. These alterations can be best demonstrated by the magnification technique. Destruction of trabecular and cortical bone occasionally with additional destruction of a joint are the typical signs of the Servelle-Martorell type AVM. These changes can usually be seen on routine radiographs, and in a great number of cases they are more obvious than in the F. P. Weber type AVM. In the Klippel-Trénaunay type AVM a lengthening of the involved limb is characteristic; no alterations in bone structure can be demonstrated.

Arteriovenous Malformations↗
PubMed1980

[The problem of cancer diagnosis in thyroid nodules: a study in an endemic area for goiter in North Sardinia].

In a 5-year prospective study in an endemic area for goiter, 275 patients with solitary thyroid nodules or with predominant nodules in multinodular goiters underwent surgery without selection on clinical grounds. The incidence of cancer was 13.1%. Preoperative diagnosis was based on personal history, local signs and radioisotope data. As compared with histologic findings, clinical and scanning data yielded a diagnostic accuracy of 19% and 31% respectively. 30% of all malignancies were not suspected preoperatively. 100% identification of cancer is possible only it all nodules are excised. Selection is, however, necessary: our data suggested that patients under 20 and over 50 years, all males, and goiters with more than 2 physical and/or scanning signs suspect for cancer should be operated upon. Much unnecessary surgery would be save and most, but not all, cancers would be excised.

Adolescent↗
PubMed1980

Treatment of acute respiratory failure with low-frequency positive-pressure ventilation and extracorporeal removal of CO2.

Terminal respiratory failure was reversed in three patients with a combination of extra-corporeal CO2 removal through a membrane lung and oxygen diffusion into the diseased lungs between mechanical breaths induced at a frequency of 2-3/min. The technique seems to prevent the pulmonary barotrauma and extrapulmonary derangements caused by conventional mechanical ventilation.

Acute Disease↗
PubMed1980

Role of serum carcinoembryonic antigen in preoperative diagnosis of cancer in patients with thyroid nodules.

Serum carcinoembryonic antigen (CEA) was measured by double antibody radioimmunoassay technique in 95 normal subjects and in 258 patients with thyroid nodules. All the normal subjects and the patients with benign nodules had normal CEA values. Increased serum CEA levels (above 50 ng/ml) were found in all medullary and undifferentiated (giant cell) carcinomas. After surgery, the CEA fell within the normal range in the patients with medullary carcinoma. High levels of CEA were also present in 26% of differentiated carcinomas. A relationship between high CEA values and the presence of metastatic disease was not found. Measurement of serum carciniembryonic antigen may be useful in the preoperative diagnosis of cancer in patients with thyroid nodules.

Carcinoembryonic Antigen↗
PubMed1980

[The early removal of amatoxins in the treatment of amanita phalloides poisoning (author's transl)].

In a 3 year period (1975-77) 50 patients have been admitted to the I.C.U. of Polyclinic Hospital of Milan for poisoning from mushrooms of Amanita genus. In 47 cases the diagnosis was confirmed "a posteriori" by serum or urinary detection of amtoxins and/or by clinical evidence of typical liver injury. Besides the symptomatologic support, the therapeutic treatment included combined removal procedures, such as peritoneal dialysis, plasmapheresis, forced diuresis. The detection by radioimmunoassay of amatoxins [6] in the serum and in the urine of these patients proves that this therapeutic treatment can be effective within about 36 hours from ingestion time. The intensive medical care and the removal approach yielded as the whole favourable results in our patients (overall mortality was 6 patients, i.e. 12,7%). It should moreover be emphasized that of the 35 patients, who had been treated with early removal techniques, 12 with ascertained amanita poisoning, had neither clinical nor biochemical evidence of hepatic damage; 14 had a moderate liver damage; 9 experienced a severe liver failure and hepatic coma occurred in 4 of the latter. These poor results can be ascribed to the severity of the poisoning as well as to a peculiar kinetic of amatoxins in each subject.

Adolescent↗
PubMed1980

[A comparison of ultrasound-Doppler sonography and angiography for stenosing lesions of supra-aortic vessels (author's transl)].

The ultrasonographic results of 158 patients with cerebro-vascular diseases were compared with the angiographic features. The results of the degree of the arterial stenoses correlated well in 66%. In 24% the ultrasonographic findings were false negative, in 10% they were false positive. With regard to the intentions of the centers of vascular surgery to operate as early as possible the ultrasound must be regarded as a screening method. The angiography is still necessary for the operation proceeding.

Angiography↗
PubMed1980

[The diagnosis of early changes in the phalanges in primary and secondary hyperparathyroidism by a direct radiological magnification technique].

A comparative study of direct radiological magnification technique was made of 22 patients with primary hyperparathyroidism, 15 patients with secondary hyperparathyroidism, and 17 patients without changes in bone structure. Only regarding the summation of all radiologically visible changes in bone structure, a hyperparathyroidism can be suspected. The differential diagnosis of primary and secondary hyperparathyroidism is mostly impossible. Furthermore we were able to demonstrate that early discrete changes in bone structure are more easily diagnosed in magnification technique than in standard technique. Therefore we regard the direct radiological magnification technique as an adequate method for patients, in whom hyperparathyroidism is suspected.

Bone and Bones↗
PubMed1980

Alteration of thyroid function in the early stage of subacute thyroiditis.

Measurement of serum triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), thyroxine-binding-globulin (TGB), antithyroglobulin antibodies (anti-hTg), thyroid 131I uptake and scanning was performed on 12 patients during the early phase of subacute thyroiditis. Serum thyrotropin (TSH) was measured during baseline conditions and following administration of synthetic thyrotropin-releasing-hormone (TRH). The stimulation with exogenous TSH was performed on 7 subjects. 131I uptake was depressed in all patients including those with solitary nodules. Free and total hormone concentrations were elevated in the three cases with diffuse gland involvement, whereas an increase of T3 alone was present in 3 patients with unilobar involvement. In the latter group and in the 2 patients with a nodular form T4, FT3 and FT4 levels were within normal limits. Interruption of the pituitary-thyroid feed-back mechanism with absence of thyrotropin response to TRH occurred in 11 patients, independent of whether thyroid hormone concentrations were elevated or normal. In one patient only with unilateral involvement, TSH responsiveness to TRH was normal while 131I uptake was not raised by exogenous TSH, indicating diffuse cellular damage. The normal values of FT3 and FT4 found in patients with normal T3 and T4 levels seem to exclude the possibility that the free hormones are responsible for the interrupted feed-back which represents the main cause of suppressed iodine uptake. However, it is possible that the pituitary-thyroid axis is responding to transient or light increases of free and total T3 and T4 still within their 'normal range'.

Adult↗
PubMed1980

[Arterial vascular scleroses in the mammogram (author's transl)].

From 1974 to April 1979 5571 mammographies were made in the Department of Radiology of the University of Ulm. In 319 cases (5,7 %) we observed calcifications of the mammarian arteries. The incidence of arterial calcifications in mammography in patients up to 60 years of age was higher than coronary calcifications could be diagnosed by chest fluoroscopy or in an autopsy series by other authors. As the small mammarian arteries show an equal histological structure as the coronary arteries, they must show the same type of calcification. Therefore we consider that calcifications of the mammarian arteries could be a sign of general atherosclerosis.

Adolescent↗
PubMed1980

[Radiological diagnosis of fibulo-talar ligamentous lesions (author's transl)].

Of 343 patients with sprained ankles the results of conventional stress a.p. roetgenograms in supination and stressed X-rays in lateral view with a device, similar to the technique, described by Noesberger, are compared. In 63 of 91 pathological findings the lesions could only be diagnosed in X-rays in lateral view. The advantages and disadvantages of both techniques are discussed. In our opinion the stressed X-rays in lateral projection are a useful method for diagnosis of ligamentous lesions of the ankle joint.

Adolescent↗
PubMed1980

[Value of the direct X-ray magnification technique for the assessment of the therapeutic success in osteochondrosis dissecans in the knee-joint (author's transl)].

The article demonstrates the diagnostic value of the direct x-ray enlargement technique, taking a group of 11 patients with osteochondrosis dissecans of a femoral condylus as an example. The method is unsuitable as a diagnostic screening method, since the informative content of the enlarged roentgenograph, is greater in a defined area only, and since the additional exposure burden should not be overlooked, especially in the patients in question, who are mostly relatively young. However, the direct radiological enlargement technique is well suited for postoperative follow-up, since it is only with the help of visualization of the increasing trabecular bone bridges between femoral condylus and dissecate, that the process of incorporation can be visualized and hence also judged in respect of its success.

Evaluation Studies as Topic↗
PubMed1980

[Early manifestation of a radiation-induced fibro-angio-myxosarcoma within an irradiation field for Hodgkin's disease (author's transl)].

The case of a fibro-angio-myxosarcoma within an irradiation field for Hodgkin's disease is reported (TD = 4025 rad). In comparison with other cases published in literature, the latent period of 4 years 10 months was relatively short. Radiation-induced sarcomas generally are observed in the irradiation field not earlier than after a free interval of 10 or 12 years, and with focal doses above 4000 rad.

Adult↗
PubMed1980

[Aneurysm of the portal vein (author's transl)].

A case of an aneurysm of the portal vein is discussed. With regard to the reported case the different possibilities of the aetiology are discussed. We consider that an aneurysm of the portal vein may be caused by liver diseases, as f.e. portal hypertension, as well as by congenital dysplasia.

Adult↗
PubMed1980

[Tolerance of the contrast medium ioxaglinic acid in angiographic examinations. A clinical study (author's transl)].

Within the framework of a clinical study, subjective and objective data were compiled on the low-osmolar contrast medium ioxaglinic acid. In 213 angiographies performed on 134 patients in the Department of Radiology I of the Ulm University Clinic from October 1979 to February 1980, it was established that unfavourable subjective symptoms were missing to a major extent. Hence, we believe that it is not justified to subject the patients to the additional stress of general narcosis when performing peripheral and cerebral angiographies. In more than 50% of the patients, the contrast medium produced either an increase or a drop in blood pressure; a state of collapse requiring treatment never occurred in any of the patients.

Angiography↗