[Burns occurring during manufacture of Thiospasmin].
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Biomedical subjects
Publications and source records attributed to M Langer.
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A report is given on 413 patients having experienced a supination trauma. All these patients were submitted to radiography according to the technics of Böhler. Arthrographies of the ankle joint were additionally effected in 105 patients because of indistinct findings of the Böhler radiographs. The arthrography of the ankle joint proves to be an examination method bearing few risks and producing most reliable results provided that it is executed within 24 hours after the traumatic incident. The findings of arthrography of the ankle joint are presented and discussed.
40 computer assisted tomographies of the vagina, the uterus and the ovaries were evaluated. The differential diagnosis between malignant and benign neoplasms is difficult unless there is spread into the soft tissues. The early diagnosis of ovarian neoplasms by axial computer assisted tomography is impossible. We are of the opinion that axial computer assisted tomography should be performed as early as possible in the diagnosis of local recurrences of malignant tumours of the female genital tract.
The localised patella defects in our material of 90 patients were largely unchanged up to nine months after surgical treatment. Persistence of soft tissue swelling round the knee correlates with continuing pain. In some cases there has been remineralisation of the patella, which can be regarded as a stage in healing. Unchanged or deteriorating radiological findings may be associated with clinical improvement or deterioration.
Ten patients who had had osteosynthetic repairs of bone defects carried out by means of bone grafts were studied. It was shown that magnification radiography permitted better and more complete evaluation of the healing process. Trabecular bone structure can be recognised and changes in the configuration and position of the trabeculae during their incorporation into the bone can be evaluated.
Elevated plasma concentrations and abnormal secretory patterns of GH have been found in patients with cirrhosis of the liver. Displacement of brain dopaminergic monoamines by false "neurotransmitters' produced in the gut has been postulated as a cause of encephalopathy. In this study basal GH plasma levels and their response to TRH and L-DOPA were determined in thirty-nine cirrhotic patients and fifteen controls. Eleven patients had evidence of encephalopathy (Group 1), twenty-eight did not (Group 2). Both basal levels and the mean peak response to TRH were significantly higher in the cirrhotic patients that in the controls (Group 3). Peak values were moderately, but not significantly, higher in Group 1 than in Group 2. The response to L-DOPA was considerably lower in the encephalopathic patients in comparison with the subjects of both Group 2 and Group 3. This finding is consistent with depletion of active "neurotransmitters' in CNS. Our data fail to demonstrate clearly whether the paradoxical response to TRH can also be related to these abnormalities of monoamine metabolism in cirrhotics.
In a patient with thrombotic thrombocytopenic purpura (TTP) severe neurological complications leading to coma were repeatedly reversed by treatment with urokinase. Although the therapeutic modalities for TTP still appear to be a matter of debate, thrombolytic treatment could be considered in TTP patients with severe organ involvement before the corresponding function is completely compromised.
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In 30 patients with decompensated autonomous adenoma of the thyroid gland, the possibility was investigated whether sonography of the thyroid gland could replace the thyroid stimulation scintigram or a diagnostically insufficient, saturated scintigram. It was found that the thyroid sonogram--which has a lower specificity--has a markedly higher sensitivity than the saturated scintigram of the thyroid gland.
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The present article evaluates 26 cases with arterial occlusion and additional polyneuropathy in diabetes mellitus or chronic alcohol addiction. For comparison, a group of 30 patients with arterial occlusion without neurologically detectable polyneuropathy were also evaluated. It is pointed out that the osseous changes in the foot bone region are due to the additionally existing polyneuropathy and cannot be explained alone by an avascular bone necrosis in arterial vascular occlusion. Changes in the sense of an arthropathy occur in our group of patients even in case of unilateral arterial occlusion, these changes occurring bilaterally in the foot bones; after reconstruction measures in the arterial vascular system, these arthropathic changes in the foot bones continue to advance in case of persisting polyneuropathy.
The role of 131Cs scan in the preoperative diagnosis of cancer was evaluated in 355 patients with either cold or nonfunctioning thyroid nodules. Nodules were classified as positive, doubtful or negative by the pattern of isotope accumulation. Among 234 patients who underwent thyroidectomy, malignant lesions were found in 10.2 per cent of cases. All carcinomas but one found during surgery had been classified as positive by radiocesium scan and were considered as highly suspicious preoperatively; one carcinoma and two papillary adenomas had been classified doubtful and considered presumably malignant. False-positive nodules were found. However, we did not document histologically malignant lesions in nodules which were classified as negative by radiocesium uptake. The routine use of 131Cs scanning may be very useful in patients with cold or nonfunctioning thyroid nodules because of its high sensitivity in excluding malignant lesions.
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Humoral immunity (immunoglobulins and C3) as well as nutritional conditions (serum albumin, transferrin) have been investigated in 23 patients in the acute phase after surgery and/or trauma. Immunoglobulin deficiency, well correlated with the severity of trauma, was observed in the most critically ill patients in the very early phase, followed by a rapid rise to near to normal values and typical immunologic response. There is no evidence that this depression of humoral immunity may enhance the risk of infectious complications in the postoperative period. Very different immunological patterns were observed in surgical patients with chronic sepsis.
The article reports on 30 patients with traumatogenic lesions of the vertebral column examined by computerised tomography. The pros and cons of CT of the spine are discussed. Since, in the authors' opinion, the advantages of CT of the spinal column are greater than the drawbacks, it is claimed that CT is justified especially in polytraumatised patients and in unstable fractures of the vertebrae. As a rule, CT of the vertebral column can replace conventional x-ray tomography and myelography in polytraumatised patients.