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Biomedical subjects

M Landthaler

Publications and source records attributed to M Landthaler.

At least 307 records · Page 17Linked to original sources
PubMed1985

[Malignant melanomas in pregnancy].

A malignant melanoma was diagnosed and treated during pregnancy in twelve patients average age 29 (19-38) years. Eleven patients were in stage I and one in stage II. One patient presented with 2 primary malignant melanomas. There was no essential difference in localisation or melanoma type in comparison with non-pregnant melanoma patients. From histological criteria (tumor thickness and prognostic index) eight patients in stage I had an intermediate and three a high risk of metastases. When compared with non-pregnant melanoma patients the pregnant patients presented with relatively more melanomas having intermediate and high metastases risk. No prediction as to the course of the disease can be made because of the small number of patients. Published data show, however, that in a pregnant subgroup pregnancy has a negative influence on the course of malignant melanoma.

Adult↗
PubMed1985

[Malignant melanomas of the vulva].

In 13 patients, mean age 57 (31-78) years, with malignant melanoma of the vulva, 7 of the tumors occurred on the Labia majora, 4 on the Labia minora and 2 on the clitoris. 8 cases involved nodular malignant melanomas, 2 cases each involved a superficial-spreading form and an acrolentiginous form, and one case involved a non-classifiable malignant melanoma. According to histological criteria 10 of 13 tumors showed a high risk of metastasising. At the time of diagnosis one of the patients was in stage II and one in stage III of the disease. Of the 13 patients, 6 died, as a result of the tumor, 5 within the first 2 years. The mean survival time was 15 (6-28) months. In three other cases the disease has reached an advanced stage: stage Ib, II or III. Up to now only 4 patients have remained symptom free, the symptom free interval averaging 62 (33-84) months. This investigation confirms the special characteristics of malignant melanomas of the vulva, which are the predominance of tumors having a bad prognosis and the rapidly progressing course of the disease.

Adult↗
PubMed1985

Treatment of benign, semimalignant, and malignant skin tumors with the Nd:YAG laser.

Reported are first experiences with Nd:YAG laser treatment of benign, semimalignant, and malignant skin tumors in 90 patients. Treated lesions included condylomata acuminata, basal cell carcinomas, solar keratosis, squamous cell carcinomas, and secondary malignant skin tumors. First clinical and histological results are promising, but long-term follow-up is required to judge the definite efficacy of this therapeutical modality.

Basal Cell Carcinoma↗
PubMed1985

[Erythema scarlatiniforme desquamativum recidivans localisatum].

Two patients are reported who had the clinical picture of localized erythema scarlatiniforme desquamativum recidivans. The lesions were thought to be drug induced in a 56-year-old female patient. In the other 54-year-old male patient, staphylococcal infections may have caused the rash.

Drug Eruptions↗
PubMed1985

[Anorectal malignant melanomas: report on 7 personal cases and 374 cases from the literature. Report of the experiences of a tumor center].

Seven cases of anorectal malignant melanoma are described and presented together with 374 cases reported on in the literature. The therapeutic procedure in stage I and II disease relies on radical surgery (abdominosacral rectum amputation), combined in cases of local metastasation with adjuvant chemoimmunotherapy using DTIC and BCG. In stage III disease therapeutic measures can achieve palliation only.

Adult↗
PubMed1984

Laser therapy of venous lakes (Bean-Walsh) and telangiectasias.

In 18 patients, venous lakes, and in 77 patients, telangiectasias were successfully treated with the argon laser. Because treatments were easy to perform and patients were not impaired by therapy, the argon laser is the treatment of choice for these conditions in our experience.

Adult↗
PubMed1984

Argon laser therapy of verrucous nevi.

In one patient afflicted with a systemic verrucous nevus, a marked improvement was obtained by repeated treatments with an argon laser. In two patients it was possible to remove localized verrucous nevus completely. There was no recurrence in the follow-up of 8 and 14 months, respectively.

Adult↗
PubMed1984

A three-year experience with the argon laser in dermatotherapy.

Since January 1980, 477 patients were treated with an argon laser, 337 afflicted with vascular lesions and 140 with nonvascular lesions. Laser therapy of portwine stains gave good results in 70% of the adult patients, but it was disappointing in patients younger than 18 years of age. Other vascular lesions, such as telangiectasia, venous lake, angiofibroma, lymphangioma, and cherry angioma, were also treated with success. For the removal of tattoos the argon laser is not an optimal modality. In our experience it should only be used in skin areas, where dermabrasion cannot be performed. Therapy of epidermal nevi, xanthelasma of the eyelids, verrucae, vulgares , and sebaceous gland hyperplasia gave preliminary promising results in some patients.

Adult↗
PubMed1983

[Treatment of zoster, post-zoster pain and herpes simplex recidivans in loco with laser light].

Red light of a krypton laser (lambda = 647 nm) was used for treatment of patients suffering from herpes zoster (n = 4), postherpetic neuralgias (n = 8) and herpes simplex recidivans in loco (n = 13). The afflicted skin was irradiated daily for ten days (laserpower 50 mw, exposure time 90 sec). Improvement was observed in 7 out of the 12 patients suffering from herpes zoster and postherpetic neuralgias respectively, and in 8 out of 13 patients afflicted with recurrent herpes simplex.

Aged↗
PubMed1983

Pityriasis rubra pilaris: a clinico-pathological and therapeutic study with special reference to histochemistry, autoradiography, and electron microscopy.

Five patients with pityriasis rubra pilaris (PRP) were analyzed by means of light and electron microscopy as well as by histochemistry and autoradiography. The results were compared with findings in psoriasis vulgaris. In PRP we found a moderate increase of the labeling index of epidermal cells, a highly increased labeling index of dermal infiltrating cells, and a mild spongiosis, and in the stratum granulosum, a decreased number of tonofilaments and an increased number of keratinosomes. The horny layer in PRP showed a pronounced histochemical and electron microscopical parakeratosis, even when histological parakeratosis was absent. In contrast with psoriasis vulgaris, there was no exocytosis of polymorphonuclear leucocytes into the epidermis, the papillomatosis index was normal, and there were no tortuous capillaries in the dermal papillae. The stratum granulosum was always present and sometimes thickened, showing electron microscopical changes different from those referred to in psoriasis. These changes point to a relatively distinct pattern of epidermal changes in PRP.

Adult↗
PubMed1983

[Morphologic studies in the treatment of nevus flammeus with argon laser].

Immediately after the argon laser impact one finds necrosis of epidermis and superficial dermis. Dilated vessels down to a depth of 0.8 mm are filled with coagulated erythrocytes. After 2 days there is initial restoration of epidermis, and dilated vessels are filled with agglutination thrombi. With and after the 6th day fibroblasts and capillary blood vessels grow into the thrombi, and later on vessels are completely replaced by granulation tissue and after 2-4 weeks by newly formed fibrous tissue.

Adult↗
PubMed1983

[Roentgen soft radiotherapy of eyelid basaliomas].

Reported are the results of soft X-ray therapy of 237 patients with 245 basal cell carcinomas of the eye lids. The medial angle of the eye and the lower eye lid were mostly affected. Histologically in 62% solid basal cell carcinomas and in 14% sclerodermiform basal cell carcinomas could be diagnostized. By soft X-ray therapy 92% of all basal cell carcinomas could be healed. All recurrences were observed in the first 2 years following radiotherapy. They were relatively more frequent at the lateral angle of the eye. Recurrences occurred in 4.9% of female patients, and in 13.0% of male patients. In two thirds they may be due to elected conditions of radiotherapy; in one third the cause of recurrences are not known. The cosmetic result was good or excellent in 95% of patients during the first 2 years following radiotherapy. After more than 5 years this rate declined to 65%. A good functional result could be obtained in 88% of the patients.

Aged↗