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Biomedical subjects

M Kyogoku

Publications and source records attributed to M Kyogoku.

At least 91 records · Page 5Linked to original sources
PubMed1979

Multiple-hormone producing lung carcinoma.

Endocrine and immunohistochemical studies were performed in a patient with lung cancer associated with gynecomastia. Elevated level of human chorionic gonadotropin (hCG) in plasma and mild hyperadrenocorticism were demonstrated by hormone assays. Postmortem examination proved the existence of anaplastic small cell carcinoma of the lung mixed with a feature of chorioepithelioma. The presence of significant amounts of adrenocorticotropic hormone (ACTH), beta-melanocyte stimulating hormone (beta-MSH), calcitonin, gastrin, hCG, hCG-alpha, hCG-beta and human chorionic somatomammotropin (hCS) in tumor tissues was demonstrated by radioimmunoassays, bioassay and immunohistochemical techniques. We present here a unique case of multiple hormones producing tumor elaborating both hormones of amine precursor uptake and decarboxylation (APUD) series (ACTH, beta-MSH, calcitonin and gastrin) and of placental origin (hCG, hCG-alpha, hCG-beta and hCS).

Adrenocorticotropic Hormone↗
PubMed1979

Role of soluble cytotoxic factor in concanavalin A-induced cellular cytotoxicity to rabbit erythrocytes.

A new sensitive and simplified method for detecting concanavalin A-induced cellular cytotoxicity was developed by using 51Cr-labeled rabbit erythrocytes as target cells, and a soluble cytotoxic factor (SCF) to rabbit erythrocytes was demonstrated with this system. From morphological studies, this factor appeared to play a major role in cellular cytotoxicity. The cytotoxic activity of SCF was removed by absorption with rabbit erythrocytes. Furthermore, the target cells pretreated with SCF and washed were subsequently destroyed. These results may indicate that SCF exerts its effect through binding to cellular receptors. Some monosaccharides showed inhibitory effects on the cytolysis of rabbit erythrocytes by SCF and on the adsorption of SCF activity to them. The significance of these findings in elucidation of the action of SCF was discussed.

Animals↗
PubMed1975

Regulatory factors on immunocytolysis of cardiac cells and mesenchymal cells.

The mode and degree of tissue specific immunocytolysis closely depend on the nature of cell-surface antigens and on the competition or balance of humoral and cell-mediated immunity. The modification of cell surface membrane by neuraminidase-treatment induced the higher susceptibility to complement-dependent cytolysis, probably on account of exposure of cryptic sites or aggregation (clustering) of sites which may be tissue specific and/or histocompatibility antigen determinants. Under the existence of large amount of antisera, complement-dependent cytolysis was dominant. On the contrary, under the situation of low dose anti-sera, normal adherent-cell-mediated cytolysis was more effective. This kind of cytolysis was inhibited easily by serum factor(s), which could be IgG, and block Fc receptor of adherent cells in competition with anti-Ig14. Although the role of serum-factor(s) is still unknown, it may act an important role in the process of establishment of autoimmune diseases.

Animals↗