Search PubMed⌕ Search

Biomedical subjects

M Kuramochi

Publications and source records attributed to M Kuramochi.

At least 145 records · Page 8Linked to original sources
PubMed1977

Responses of plasma renin to sodium load in two types of experimental renal hypertension.

A sodium-rich diet was given 20 rabbits with 2-kidney hypertension (clipping of one renal artery with an intact contralateral kidney), 19 rabbits with 1-kidney hypertension (clipping of one renal artery with contralateral nephrectomy), and 13 normal rabbits. Sodium content of the diet was twice as much as the regular diet. The sodium load was started 10 weeks after clipping of the renal artery and lasted for 2 weeks. During the sodium load blood pressure did not show any significant changes but hematocrit was reduced in all 3 groups. Plasma renin activity (PRA) was clearly suppressed in 10 of 19 animals with 1-kidney hypertension and in 6 of 13 normal animals, but only in 4 of 20 animals with 2-kidney hypertension (p less than 0.04). The results indicate that PRA was more easily suppressed in animals with 1-kidney hypertension than in those with 2-kidney hypertension by a sodium-rich diet and the suppressive response is not associated with alterations in blood pressure.

Animals↗
PubMed1977

Increase of hematocrit in experimental renal hypertension and its reversal.

Hematocrit can be increased in experimental animals with renal hypertension of two-kidney type. The present study showed that the increased hematocrit was returned to normal by removal of the clipped kidney. The left renal artery was clipped in 13 rabbits with an intact contralateral kidney, and a sham operation was performed in 10 rabbits as a control. After an interval of 10 weeks the left kidney was removed in all animals. Blood pressure, hematocrit, hemoglobin content, and erythrocyte count were rapidly increased and remained raised after clipping of the renal artery but they did not show any significant changes after sham operation. A transient but significant increase of reticulocyte count was found at the end of the first week after clipping of the renal artery. Removal of the clipped kidney was followed by a rapid return of hematocrit, hemoglobin content, and erythrocyte count to normal within 2 weeks. Blood pressure was also decreased but not returned to normal by removal of the clipped kidney.

Animals↗
PubMed1975

Vectorcardiograms of electrocardiographic incomplete left bundle branch block.

Vectorcardiographic and pathologic studies were made on 21 cases with electrocardiographic incomplete left bundle branch block. Marked left ventricular hypertrophy, severe coronary sclerosis and myocardial infarction were more frequently observed in the presence of incomplete left bundle branch block than in the control group. A figure-of-eight pattern of the QRS loop in the horizontal plane, a classical pattern of incomplete left bundle branch block hitherto described, was observed only in 9 of 21 cases, although the normal initial deflection of the QRS loop directed to the right and anteriorly was absent in all the cases. The configuration of the QRS loop in the horizontal plane was very helpful for the diagnosis of associated myocardial infarction and marked left ventricular hypertrophy. A smooth figure-of-eight QRS loop in the horizontal plane was observed in the cases with marked left ventricular hypertrophy, while a bizarre distorted QRS loop with a figure-of-eight pattern was observed in the cases with extensive myocardial infarction. A T loop directed to the right and posteriorly was also considered to be a suggestive sign of myocardial infarction. The present observations clearly indicate the usefulness of vectorcardiograms for clinical diagnosis in the presence of electrocardiographic incomplete left bundle branch block. The results also suggest that it seems to be unlikely that one common mechanism is responsible for the development of electrocardiographic encomplete left bundle branch block.

Aged↗
PubMed1974

Effect of removing the clipped kidney on renovascular hypertension in rabbits.

Constriction of one renal artery in the presence of the opposite kidney can produce persistent hypertension which is often associated with increase in plasma renin activity, decrease in serum potassium and increase in water intake. In the present study the clipped kidney was removed in 15 hypertensive rabbits 12 to 54 weeks after the constriction. Blood pressure showed a prompt and transient fall which was followed by a slight rebound and subsequently a gradual decline. However, it still remained above the normal 5 weeks after removal. Removal of the clipped kidney resulted in return to normal of increased plasma renin activity, decreased serum potassium and increased water intake at the end of the postoperative first week.

Animals↗