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Biomedical subjects

M Kudo

Publications and source records attributed to M Kudo.

At least 415 records · Page 23Linked to original sources

Prevalence of hypertension in diabetes mellitus--its relation to diabetic nephropathy.

The prevalence of hypertension was studied in 374 patients with non-insulin dependent diabetes mellitus (NIDDM) and in 1197 non-diabetic controls. The diagnosis of hypertension was made when the mean systolic pressure of three measurements on different occasions was 151 mmHg or greater, or the mean diastolic pressure was 91 mmHg or greater. The prevalence was 42.8% in the diabetics and 17.8% in the controls. It showed a significant difference over age 31 (p less than 0.05). Proteinuria (p less than 0.001), abnormal ECG (p less than 0.01), hyperlipidemia (p less than 0.05) and hypertensive or sclerotic changes of the retina (p less than 0.001) were more frequently observed in the diabetics than in the controls. Hypertension was found in 71% of those with proteinuria, 48% with diabetic retinopathy, 61% with abnormal ECG and 54% with hyperlipidemia in the diabetics. The incidence of proteinuria was 22.8% in the diabetic hypertensives and was 8.3% in the non-diabetic hypertensives (p less than 0.001). 24 subjects out of 119 diabetics, who were normotensive at their initial visits, became hypertensive within 10 years (N-H), and 95 remained normotensive (N-N). 38% of N-H showed proteinuria already on their initial examinations and 3% of N-N did. 73% of those who showed proteinuria on their initial examination became hypertensive and 13% of those who were free from proteinuria did (p less than 0.001). The results suggest that diabetic nephropathy plays an important role in developing hypertension in diabetics.

Adult↗

Thalamocortical projections to layer I of the primary auditory cortex in the cat: a horseradish peroxidase study.

HRP injected into layer I of the primary auditory cortex (AI) in the cat labeled neuronal cell bodies ipsilaterally in the medial, dorsal and ventrolateral divisions of the medial geniculate nucleus (MGN), suprageniculate nucleus, and nucleus of the brachium of the inferior colliculus. MGN neurons labeled after HRP injected into layer I were statistically smaller than those labeled after HRP injected into layer IV.

Animals↗

The intercollicular region in the cat: a possible relay in the parallel somatosensory pathways from the dorsal column nuclei to the posterior complex of the thalamus.

Neuronal connections of the intercollicular region were studied in the cat by the anterograde and retrograde WGA-HRP and HRP methods. The results indicate that some neurons in the intercollicular region, which comprises the intercollicular nucleus, external and pericentral nuclei of the inferior colliculus, and nucleus of the brachium of the inferior colliculus, receive afferent fibers from the dorsal column nuclei, bilaterally with a contralateral dominance, and send their axons to the lateral division of the posterior complex of the thalamus, bilaterally with an ipsilateral predominance.

Afferent Pathways↗

Ascending projections from the nucleus of the brachium of the inferior colliculus in the cat.

Ascending projections from the nucleus of the brachium of the inferior colliculus (NBIC) in the cat were studied by the autoradiographic tracing method. Many fibers from the NBIC ascend ipsilaterally in the lateral tegmentum along the medial border of the brachium of the inferior colliculus. At midbrain levels, fibers from the NBIC end in the superior colliculus, the pretectum, the central gray and the peripeduncular tegmental region bilaterally with ipsilateral predominance. NBIC fibers to the superior colliculus are distributed densely to laminae VI and III throughout the whole rostrocaudal extent of the colliculus. In the pretectum, NBIC fibers terminate in the anterior and medial nuclei and the nucleus of the posterior commissure. NBIC fibers to the dorsal thalamus are distributed largely ipsilaterally. Many NBIC fibers end in the dorsal and medial divisions of the medial geniculate body, but few in the ventral division. The NBIC also sends fibers to the suprageniculate, limitans and lateralis posterior nuclei and the lateral portion of the posterior nuclear complex; these regions of termination of NBIC fibers constitute, as a whole, a single NBIC recipient sector. Additionally, the NBIC sends fibers to the centralis lateralis, medialis dorsalis, paraventricular and subparafascicular nuclei of the thalamus.

Afferent Pathways↗

Plasma vasopressin response to extracorporeal circulation in children.

Plasma vasopressin levels were measured during open-heart surgery in nine children. The control value of vasopressin was 5.5 +/- 1.5 (s.e.mean) microU/ml. During extracorporeal circulation, a maximum 7.3-fold increase of plasma vasopressin level was demonstrated. This high level of vasopressin was considered to have circulatory effects rather than anti-diuretic effects.

Age Factors↗