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Biomedical subjects

M Krause

Publications and source records attributed to M Krause.

At least 289 records · Page 16Linked to original sources
PubMed1977

Hemoglobin F Koelliker (alpha2 minus 141 (HC 3) Arg gamma2); a modification of fetal hemoglobin.

An electrophoretically HbA-like hemoglobin component is produced in increasing amounts during storage in hemolysate preparations from macerated tissue (liver, kidney, spleen) of fetuses. Within twenty four hours after hemolysate preparation the "fast moving" fraction increases up to 40 per cent of total hemoglobin, while the concentration of HbA remains constant (5 - 7%) in hemolysates obtained from peripheral blood of the same donor individuals. By structural studies (fingerprint and aminoacid analysis) the HbA-like component was identified as an artefact of HbF, characterized by the absence of the C-terminal arginine of the alpha chains. From experimental data it is concluded, that the break down product results from a digestion of HbF by carboxypeptidase B, the enzyme being released from the macerated tissues. Analogous to a modification of HbA, i.e. Hb Koelliker (alpha2 minus 141 Arg beta2), the structure of the degradation product of HbF is alpha2 minus 141 Arg gamma2 (HbF Koelliker).

Amino Acids↗
PubMed1977

[Treatment results in supervoltage therapy of malignomas of the collum uteri].

Based on a material of 136 patients with cervix cancer the results of radiation therapy partially combined with intracavitary radiotherapy are discussed. The 5-year survival rates are accordanted with good results of other authors. The 5-year survival rate is 17,6% in progressive cases with tumour invasion in the urinary bladder, from has to derived, that by application of megavolt therapy this group of patients is an indication for radiation therapy under curative terms.

Adult↗
PubMed1977

[Sequela of pelvic fractures (author's transl)].

Different kinds of pelvic fractures with the presumingly most frequent and serious complication of a socket fracture with luxation and the resulting danger of a hip-condyle necrosis are described concisely. Certain problems of therapy resulting from this are partially dealt with. Expert opinions of the accident sequences and the degree of body damage, which has to be assessed, are pointed out. As a progression must be faced in case of a posttraumatic coxarthrosis a re-examination over a longer period (10 years and more) is recommended.

Accidents, Traffic↗
PubMed1976

[Aspects of the risk-free use of micro-catheterization in 3342 examinations].

The microcatheterization for purpose of sounding of the right heart has proved itself in the prediagnostics of vitia cordis, for verification of the latent cor pulmonale, especially in combination with the bicycle ergometer load, and in the intensive medicine in the permanent measurement of the pressure of the pulmonary artery. The method gives the advantage of the frequent reproducibility and at the same time uncomplicated usability. In 3,342 microcatheter investigations only eight complications appeared (0.24% of the cases). Practical methodical references are given and possibilities of error in registering the pressure are indicated.

Cardiac Catheterization↗
PubMed1976

Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer.

In a recently completed study, combination chemotherapy consisting of bleomycin, adriamycin, cyclophosphamide, and vincristine was given to 29 patients with oat cell lung cancer. There were no cases of pulmonary fibrosis in these 29 patients. Although several of these patients had prior radiotherapy, none had concomitant radiotherapy and chemotherapy. This same four-drug chemotherapy regimen was combined with concomitant radiotherapy in 13 patients with oat cell lung cancer. There were three cases of fatal pulmonary fibrosis and two other cases of clinically significant pulmonary fibrosis. All five cases of pulmonary fibrosis occurred several weeks after completion of a six-week course of bleomycin (total dosage 90 units). It is concluded that bleomycin cannot be safely administered while patients are receiving radiotherapy to the lung.

Bleomycin↗
PubMed1976

Oat cell carcinoma of the lung. Early treatment results of combination radiation therapy and chemotherapy.

Since August 1974, 50 patients with histologically proven oat cell carcinoma of the lung were treated at Indiana University Hospitals with a combination of adriamycin, cyclophosphamide, Oncovin, BCG immunotherapy, and radiation therapy to the primary lung tumor and whole brain. Twenty-nine patients are eligible for a 6-month follow-up and are included in this report. All 29 patients responded to therapy; 12 patients (41%) had a minimum of 50% reduction in tumor mass and 17 patients (59%) had complete clinical remission of disease. Eight (38%) of the 29 patients have remained in complete remission from 6 to 14 months, and 90% of the patients survived a minimum of 6 months. This represents a considerable improvement in survival rates over what had been obtained at Indiana University Hospitals previously.

Adult↗
PubMed1976

[Hemodynamic analysis of pulmonary circulation by microcatheter technique in healthy persons and in patients with pulmonary silicosis (author's transl)].

A comparison of hemodynamic analysis of pulmonary circulation in 18 healthy men (PM less than 20 Torr) and 19 patients with pulmonary silicosis (PM larger than or equal to 20 Torr) at rest and under work load gave following results: In most healthy persons pulmonary pressure rose under load while resistance of pulmonary circulation decreased significantly. In patients with silicosis pulmonary pressure being elevated at rest reached pathological values under load while resistance of circulation decreased less. There was no difference in cardiac time-volume between both groups. The authors found a linear correlation between cardiac time-volume and oxygen uptake related to body surface. They derived a formula of approximating cardiac time-volume by oxygen uptake and body surface.

Cardiac Output↗
PubMed1976

[Bodyplethysmographic analysis in patients with silicosis (author's transl)].

Pulmonary airway resistance was measured in patients with silicosis and in normal subjects using a volume-constant bodyplethysmograph. Values of total resistance RT were compared with spirometric ventilation parameters, oxygen tension during steady-state-exercise and arterial blood pressure. The analysis shows a significant relationship between status of silicosis and the degree of resistance. Resistance values were found enhanced also in comparison with a decrease of vital capacity and FEV1 and with an increase of residual volume and arterial blood pressure.

Blood Pressure↗
PubMed1976

[Relation between manifest bronchial obstruction and bronchial hyperreactivity (author's transl)].

Based on the inquiry of 252 patients an investigation was carried out concerning the frequency of manifest bronchial obstruction in dependence on the bronchial hyperreactivity. Patients with bronchial hyperreactivity showed more frequently with a high significance as well a decrease in the FEV1 as an increase of resistance. Therefore in dependence on the occurrence of a manifest bronchial obstruction also the probability of a simultaneous presence of bronchial hyperreactivity increases. The results are important for understanding the functional dynamics of the bronchopulmonary system, especially the evocation of dyspnea by irritation of the respiratory tract.

Adolescent↗
PubMed1975

[Demonstration of a non-invasive measurement of the heart minute volume].

With the help of a rapidly indicating oxygen gas analyser and the additional use of the rerespiration of a gas mixture, containing nitrogen and carbon dioxide, we succeed in analysing the partial oxygen pressure in the mixed venous blood and thus establishing non-operatively the minute output of the heart according to Fick's principle.

Cardiac Output↗
PubMed1975

[Clinical-pharmacological studies on the effect of mephentermin and methamphetamine on the hemodynamics of the lung circulation].

In haemodynamic investigations of altogether 40 male probands with normal and restricted functional capacity of the lungs the result of an intravenous injection of mephentermine (30 mg) or methamphetamine (15 mg) was a transient increase of the mean pressure in the pulmonary artery and of the resistance of the pulmonary vessels. Temporarily parallel the arterial mean pressure and the resistance of the vessels in the greater circulatory system in most cases increased by about the same, in healthy persons after application of methamphetamine by a smaller relative amount. In the dosage used the vasoconstrictive effect of methamphetamine was altogether only somewhat more expressed. At the time of the maximum increase of the mean pressure of the pulmonary artery in healthy persons methamphetamine had a negative chronotropic and inotropic effect. It is referred to practical therapeutic consequences.

Adult↗