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Biomedical subjects

M Kramer

Publications and source records attributed to M Kramer.

At least 73 records · Page 4Linked to original sources
PubMed1979

Effects of temazepam, flurazepam and quinalbarbitone on sleep: psychomotor and cognitive function.

1 The effect of temazepam 15 and 30 mg, flurazepam 15 and 30 mg, quinalbarbitone 100 and 200 mg and placebo were studied in 14 healthy male volunteers according to a Latin-square design. At 14-d intervals subjects received capsules 30 min before bedtime on 2 consecutive nights and were evaluated for objective sleep characteristics, for morning estimates of sleep characteristics, and for cognitive and psychomotive performance and subjective state at 3.5, 10.0 and 22.5 h after ingestion. 2 Changes in sleep induction and sleep maintenance were observed with temazepam 30 mg and flurazepam 30 mg had the greater effect on cognitive performance, whereas quinalbarbitone 20 mg had the greater effect on psychomotive performance. Subjective assessments of alertness were most affected by flurazepam, and by quinalbarbitone 200 mg. 4 The results suggest that temazepam produces less residual effects and is shorter acting than quinalbarbitone and flurazepam.

Adult↗
PubMed1979

The effect of a single dose of quazepam (Sch-16134) on the sleep of chronic insomniacs.

The present study evaluated the efficacy of 25 mg of quazepam, a new benzodiazepine hypnotic, in a population of chronic insomniacs. The results indicate that a single dose (25 mg) administered for one night was efficacious when measured both objectively by polysomnographic recording and subjectively by questionnaire with no reported side-effects. The change in the objective measures paralleled the direction of change in subjective measures. Sleep efficiency and sleep maintenance were improved without EEG changes in Stages 2, 3-4, and REM. Further study is needed to evaluate the effects of chronic administration of different doses of quazepam in chronic insomniacs.

Adolescent↗
PubMed1979

Bicultural training: a cost-effective program.

The effects of a bicultural training program in easing adjustment to the work world were studied on new graduate nurses working in eight medical center hospitals. Data from that study are used to examine program costs per new graduate-head nurse dyad. The cost effectiveness of the bicultural program is illustrated by comparing program costs with savings resulting from decreased turnover among new graduates who receive bicultural training. The mean time and cost estimates for the program may be used by others to determine cost effectiveness of bicultural training in their own institutions.

Costs and Cost Analysis↗
PubMed1979

An analysis of behavioral contingencies in clinical teaching.

Principles of a contingency management were applied in analyzing student reports on clinical instruction. In behavioral science, a contingency is a relationship between a behavior and its effect. The analysis identifies contingencies arranged by clinical instructors that unintentionally interfere with learning. The faculty responded to the findings by planing changes to overcome the problems identified. Prior to the study, many of the problems uncovered were not recognized by the faculty. Students are usually not open about such sensitives areas of feedback. If dental faculty members of other institutions do not feel that similar findings apply to their schools, the authors recommend that they conduct an analogous study.

Attitude↗
PubMed1979

Narcolepsy and automatic behavior: a case report.

Narcolepsy is characterized by excessive daytime sleepiness and cataplexy, which may be accompanied by hypnogogic or hypnopompic hallucinations and sleep paralysis. Automatic behavior is a relatively newly recognized symptom of the narcolepsy syndrome. This case report describes a particularly troublesome sort of automatic behavior--shoplifting--in a narcoleptic patient. It illustrates how a sleep-laboratory evaluation was used to confirm the diagnosis of narcolepsy and considers aspects of the treatment of the problem.

Automatism↗
PubMed1978

Metabolic effects of clofibrate on experimental animals.

The effect of ethyl-alpha-(p-chlorophenoxy)-isobutyrate (clofibrate, Miscleron) on certain parameters of lipid and carbohydrate metabolism was studied in male and female white rats. The vitamin A content and the mixed function oxydase activity in the liver was also examined. 1. In short-term experiments over 10 to 30 days clofibrate significantly influenced the examined parameters. In a long-term experiment (9 months), however, these changes were no more observable. 2. Clofibrate exerted a protective effect against lipid mobilization following physical exercise (swimming). 3. No significant differences between male and female rats after clofibrate treatment could be observed.

Animals↗
PubMed1977

Intraerythrocytic adaptation (2,3 DPG,P50) in thalassemia minor.

P50 and 2,3 DPG content of erythrocytes were determined in 25 patients with heterozygous beta thalassemia minor to assess the adaptive mechanisms to anemia. 2,3 DPG levels were appropriately elevated for the degree of anemia. However, P50 values were not proportionately increased. No correlations were noted between hemoglobin level, 2,3 DPG, or P50 and the presence of symptomatic complaints of fatigue or weakness in these heterozygous patients.

Diphosphoglyceric Acids↗