Search PubMed⌕ Search

Biomedical subjects

M Kono

Publications and source records attributed to M Kono.

At least 307 records · Page 17Linked to original sources
PubMed1985

[Gastrointestinal complications caused by high-dose-rate intracavitary irradiation of carcinoma of the uterine cervix].

We treated 64 patients with carcinoma of the uterine cervix with high-dose-rate intracavitary irradiation between 1978 and 1984. Of the 52 patients who were followed for more than two years, gastrointestinal complications occurred in 11 (21%): six grade I patients (12%), two grade II patients (4%) and three grade III patients (6%). The patients were graded according to the severity of the complications. The three patients with grade III complications underwent emergency surgery because of ileus or perforation of the gastrointestinal tract. It is suggested that these severe complications are liable to occur in patients given more than seven fractions of intracavitary irradiation in a fraction dose of 6 Gy to point A or previously operated on in the pelvic cavity. Accurate center shield in relation to tandem sources is also emphasized.

Adult↗
PubMed1985

Mediastinal lymphography using non-ionic, water-soluble contrast medium.

To circumvent the "irritative" effects of oily contrast and the high permeability of ionic water contrast medium, we reexamined the usefulness of mediastinal lymphography in dogs and patients using non-ionic (low permeability) water soluble contrast. Despite better delineation of lymph channels and nodes by indirect (transcarinal bronchofiberscopy) and direct (nodal injection at thoracotomy) mediastinal lymphography, the problem of false positive and false negative imaging remains.

Animals↗
PubMed1984

[Minute gallbladder cancer--case report with suggestions regarding a possibly unique histogenesis].

A 35-year-old woman with minute gallbladder cancer is presented. Cholecystectomy for gallstones resulted in recurrent colic lasting for a few years. Examination of the resected bladder under a dissection microscope disclosed a minute polypoid tumor with cylindroid appearance measuring 2.0 X 0.5 mm; it was located on a thin membraneous stalk in the neck region. Histologically, the tumor consisted chiefly of well-differentiated adenocarcinoma, in its periphery there were adenomatous residues; the stalk was free of neoplastic change. Blood group substances were completely absent in the cancerous tissues, they were present in adenomatous tissues. We hypothesize that the present cancer derived from the minute gallbladder adenoma via malignant change at an early stage development, suggesting a unique mode for an adenoma-carcinoma sequence in the gallbladder. The present case is believed to be the smallest cancer among reported cases and we propose to define minute gallbladder cancer as that less than 5 mm in maximum diameter.

Adenocarcinoma↗
PubMed1984

[ESR (electron spin resonance) analysis of cancer patient lymphocytes stained with hematoporphyrin D].

Administration of hematoporphyrin derivative (HPD) with the association of laser beam irradiation has recently been employed for the diagnosis and treatment of cancer. This methodology is based on the tumor affinity of HPD and the phenomenon of fluorescence generation under the specific wave laser beam. Furthermore, laser irradiation induces a photochemical reaction of HPD, which may kill the HPD uptake cancer cells. Utilizing the electron spin resonance (ESR) that produces HPD radicals, we measured the level of radicals in the lymphocytes separated from the peripheral blood of patients with cancer of various types and sites and that from normal controls, as well as in the culture cancer cells (K-562). The level of radicals in the lymphocytes from the cancer-bearing patients and culture cancer cells was found to be significantly elevated as compared with that in the lymphocytes of normal controls and patients with noncancerous conditions such as SLE, hepatic disease, etc. This procedure appears to be very useful for the diagnosis of cancer, and this is the first report in the world.

Adult↗
PubMed1984

[Two-dimensional echocardiographic evaluation of left atrial shape and size].

We investigated the influence of the miscellaneous structures surrounding the left atrium on left atrial shape and examined the feasibility and problems in evaluating its size using the anteroposterior dimension of the M-mode echocardiogram. Using two-dimensional echocardiography, left atrial anteroposterior short-axis dimension (S), long-axis dimension (L), transverse-axis dimension (T) which cross perpendicularly one another, and area in the long-axis section (AREA) were measured in 84 subjects. The left atrial size was defined as AREA X T. The population of this study consisted of 24 subjects without heart disease, 24 with mitral valve disease and 34 with miscellaneous heart diseases other than mitral valve disease. Some of them were associated with the thin chest, chest deformity by thoracoplasty or the markedly dilatated right atrium. In subjects with the thin chest the left atrium was compressed in the anterior and posterior directions, in patients who underwent thoracoplasty it was elongated in the cranial and caudal directions, and in those with the markedly dilatated right atrium it was compressed in the right and left directions. It can be speculated that surrounding structures have some direct effects on left atrial dynamics. As left atrial size increased, these three dimensions (S, L and T) increased disproportionally. Because the contribution of each dimension to the left atrial volume change is proportional to the ratio of dimensional change and S has the largest ratio, S contributed to left atrial volume change more than the others. That is the reason that left atrial volume was not proportional to S or S3. The relationship between S and AREA during one cardiac systole was almost linear in individual studies. The slope in the S-AREA relation, however, was greater in the cases with a larger value of S. Therefore, when the extent of the change in S is used as an index of atrial volume change, it should be normalized by S. Because the left atrium expanded in any directions, either S or other dimensions reflected its size. In cases with the distorted left atrium, however, evaluation of left atrial size by the use of a single dimension alone was inadequate.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1983

The osseous structure of the carpal groove.

Transverse osseous structure of the carpal groove was studied using serial sections and microradiography. The width and area of the carpal groove were measured in x-ray films of each section. The wrist and carpal region was divided into six levels: 1) radio-ulnar joint level, 2) proximal level of the carpal bones, 3) intermediate level of carpal bones, 4) distal level of carpal bones, 5) the first C-M joint level, and 6) bases of the metacarpal bone level. The width of the carpal groove averaged 32 mm at the inlet and became narrower toward the outlet. Both inlet and outlet areas were small, the largest area was observed at the middle part. Although the carpal bones did not support the body weight, a remnant of the trajectorial architecture of the trabeculae was observed.

Carpal Bones↗
PubMed1983

R plasmids in Corynebacterium xerosis strains.

Plasmids coding for resistance to chloramphenicol, erythromycin, kanamycin, streptomycin, and tetracycline have been found in strains of Corynebacterium xerosis isolated from patients with otitis media.

Anti-Bacterial Agents↗
PubMed1983

Mechanism of resistance to some cephalosporins in Staphylococcus aureus.

The mechanism of resistance to some cephalosporins in Staphylococcus aureus strains was investigated with high-pressure liquid chromatography and nuclear magnetic resonance spectrometry. Drug inactivation by penicillinase was found to be the main mechanism of resistance to cefazolin, cephaloridine, and cephalothin in S. aureus.

Cephalosporins↗
PubMed1983

[Radiographic diagnosis of lung cancer and lymph nodal metastasis of the mediastinum].

Primary lung cancer is divided into two types: peripheral type and hilar or central type. Peripheral lung cancer appears as a solitary mass or patchy shadow and is typically lobulated or irregular in shape. Any regular or scattered calcification within or around the lesion on routine radiographs indicates that it is benign. Hilar or central lung cancer may accompany hilar and mediastinal lymphadenopathy, lobar collapse and consolidation, and pneumonitis distal to a mass in a large bronchus. In addition, it is very important that the metastases of the hilar and mediastinal lymph nodes are detected preoperatively or prior to conservative therapy. On 44 cases of lung cancer pathologically proved, the diagnostic accuracy of the metastases of the hilar or mediastinal lymph nodes is 42.4% preoperatively on routine radiographs.

Adenocarcinoma↗
PubMed1983

[Comparative study of the activities of beta lactamase inhibitors by nuclear magnetic resonance spectrometry].

Nuclear magnetic resonance (NMR) spectrometry were applied for the measurement of inhibitory activity of some drugs towards beta-lactamase in living cells. From the integrated values of the signals based on 5-H and 6-H of beta-lactam ring or methyl proton of C-2 position of ABPC as substrate, the inhibition dose of 50% (ID50 value) to beta-lactamase activity under the condition containing 10 mg of ABPC was calculated. The ID50 values (mg) of clavulanic acid (CVA), N-formimidoylthienamycin (MK 0787) and dicloxacillin (MDIPC) known as beta-lactamase inhibitor were less than 0.0001, 0.4 and 0.6, respectively, when each inhibitor was preincubated for 10 minutes. The ID50 values of cefoxitin (CFX), cefmetazole (CMZ), latamoxef (LMOX) and cefotaxime (CTX) known as beta-lactamase resistant drugs were 1.4, 1.3, 0.4 and more than 20.0, respectively, under same condition. From these results, it was clearly shown that CVA is excellent inhibitor to the beta-lactamase of Richmond's class III in living cells. And the inhibitory effect of CFX, CMZ and LMOX was also clearly shown.

Anti-Bacterial Agents↗