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Biomedical subjects

M Kondo

Publications and source records attributed to M Kondo.

At least 1,297 records · Page 72Linked to original sources
PubMed1982

Identification of taurine occurring sporulating cells of Bacillus subtilis.

An unidentified ninhydrin-positive substance was detected in trichloroacetic acid extract from the sporulating cells of Bacillus subtilis NRRL B558. The substance was isolated as the corresponding 2,4-dinitrophenyl (DNP) derivative, the structure of which was identified with a pyridinium salt of DNP-taurine, based on spectral and synthetic evidence. a pyridine molecule should be introduced into a taurine molecule during the isolation procedure and hence, the original amino acid was assigned to taurine. Taurine was accumulated into the cells from the medium during the early stages os sporulation, and thereafter metabolized or excreted.

Bacillus subtilis↗
PubMed1982

Complement levels in human tears.

The single radial immunodiffusion technique was modified to determine tear complement component C3 with small sample volume. The C3 levels in the tears from 18 normal subjects and 42 patients with ocular diseases were determined using this method. In the normal subjects, the mean level of tear C3 was 5.12 mg per 100 ml. The physiological level of tear C3 was estimated to be less than 10 mg per 100 ml from the results in normal subjects and patients with noninflammatory ocular diseases. The cases of severe inflammatory diseases such as antiviral keratoconjunctivitis, herpetic keratitis and acute catarrhal conjunctivitis showed a high level of C3 in the tears. The C3 level was relatively low in the cases of mild inflammatory diseases such as allergic conjunctivitis. These results indicated that protein concentration of C3 in the tear was proportional to the severity of inflammation of the anterior ocular segment.

Complement C3↗
PubMed1982

Protection by BCG, levamisole, PS-K, OK-432, and vitamin E against carbon tetrachloride hepatotoxicity.

It has been suggested that lipid peroxidation is an important factor in the pathogenesis of carbon tetrachloride (CCl4) hepatotoxicity. In the present work, experimental liver injury induced by CCl4 was inhibited by the immunopotentiators such as BCG, levamisole, PS-K, and OK-432, and despite exposure to CCl4 the liver tissue levels of thiobarbituric acid (TBA) reactive substances were not increased in rats pretreated with immunopotentiators. Though immunopotentiators exhibit a protective action against CCl4-induced lipid peroxidation damage, their clinical role and mechanism of protective action on the liver have yet to be clarified in detail.

Adjuvants, Immunologic↗
PubMed1982

[An experimental study on esophageal transmucosal potential difference and its diagnostic value in esophagitis].

Since Donné reported on the existence of transmucosal electrical potential difference in 1834, many investigations have been made on this subject. Recently, the fact that the potential difference reflects mucosal integrity has been utilized to examine the extent of mucosal pathology of various parts of the alimentary tract. Few reports, however, have so far been made on the esophageal mucosal potential difference. The author experimentally studied on the esophageal mucosal potential difference to seek its significance in making the diagnosis of esophagitis. A total of 25 mongrel dogs were used and divided into two groups, control and esophagitis group. Endoscopic examination, recording of potential difference and autopsy were made after preparation of esophagitis. The results obtained were as follows: 1) Esophagoscopy of the esophagitis group revealed various types of esophagitis in all the dogs. 2) Gastric mucosal potential difference varied according to the degree of mucosal damage. 3) In esophagitis group, esophageal mucosal potential difference showed the higher values than those of the control group. 4) At the area of localized esophagitis, the value of esophageal mucosal potential difference was higher than that of the intact mucosa. It is concluded that the measurement of potential difference of the esophageal mucosa is useful for detecting the extent of esophageal mucosal damage.

Animals↗
PubMed1982

alpha-Tocopherol level in liver diseases.

Serum levels of alpha-tocopherol (vitamin E) were determined in various types of liver diseases, and as a results, it was revealed that serum alpha-tocopherol was significantly depressed in acute hepatitis (p less than 0.01, n = 22), alcoholic hepatitis (p less than 0.001, n = 9) and fulminant hepatitis (p less than 0.001, n = 6). There was a significant correlation between serum levels of alpha-tocopherol and beta-lipoprotein (r = 0.92, p less than 0.001, n = 17). Though there was no correlation between serum levels of alpha-tocopherol and triglyceride, there was a significant correlation between alpha-tocopherol and cholesterol (r = 0.57, p less than 0.01, n = 21), and phospholipid (r = 0.49, p less than 0.05, n = 18). There was no correlation between serum levels of alpha-tocopherol and other liver function tests. These facts suggested that the diminished serum vitamin E in patients with liver diseases is ascribable to the depression in blood level of beta-lipoprotein that results from liver disorders, because the liver is the major supply source of beta-lipoprotein.

Adolescent↗