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Biomedical subjects

M Kojima

Publications and source records attributed to M Kojima.

At least 973 records · Page 54Linked to original sources
PubMed1976

Ceroid-like histiocytic granuloma of gall-bladder --a previously undescribed lesion--.

In the present study, 13 cases of a peculiar gall-bladder granuloma characterized by marked proliferation of ceroid-filled brown histiocytes were pathomorphologically, histochemically and ultrastructurally examined to define the pathologic features of such a lesion previously undescribed in the literature. The lesion grossly showed a granulomatous appearance of yellow brown to dark brown color developing in the wall of gall-bladder. Histologically, there was proliferation of histiocytes containing abundant brown pigment granules in their cytoplasm. The pigment granules proved to have staining characteristics closely resembling those of lipogenic ceroid-like pigment. Ultrastructurally, these granules showed membrane-bound, pleomorphic osmiophilic inclusions of heterogenous materials. With regard to the pathogenesis of this granuloma, it may be suggested that lipid components of bile juice, particularly unsaturated fatty acids and phospholipids, play an important role as a source of ceroidogenesis in the proliferating histiocytes.

Adolescent↗
PubMed1976

An ultrastructural and histochemical study on bone lesions of Hand-Schüller-Christian disease.

A correlated light microscopical, histochemical and ultrastructural study was made on bone lesions repeatedly biopsied from three patients with Hand-Schüller-Christian disease. The histiocytic cells proliferating in the early lesions had a markedly indented nucleus and contained in their cytoplasm varying numbers of Langerhans cell granules and round or irregular-shaped lipid droplets. Histochemically, the lipid droplets were verified to the lipo-protein rich in fatty acids. Such histiocytic cells differ from highly phagocytic histiocytes or macrophages because of indistinct phagocytotic activity, and are regarded as a metabolic type of histiocytes. The late lesions were mostly dominated by a xanthogranulomatous tissue chiefly comprised of xanthoma cells and collagen fibers. The xanthoma cells were usually filled with numerous lipid vacuoles which were histochemically proved to mainly contain cholesterol. Almost all the xanthoma cells were closely attached to collagen fibers and often had well-developed rough endoplasmic reticula. Ultrastructurally, it is suggested that the xanthoma cells are originated from fibroblasts or fibrocytes. As an important factor to induce proliferation and xanthoma cell transformation of fibroblasts in the late phase, the presence of such a lipoprotein produced in the histiocytic cells of the early phase is emphasized.

Adenosine Triphosphatases↗
PubMed1976

[Electro-ophthalmological observations on the course of unilateral tapetoretinal degenerations (author's transl)].

A 32-year-old female patient suffering from a unilateral tapetoretinal degeneration for at least 7 years was investigated. The affected eye exhibits a typical fundus, concentric reduction of visual field, and a monophasic course of dark adaptation. The electroretinogram of the affected eye is extinguished; the electrooculogram does not show a light peak. The visual evoked cortical potential of both eyes shows a normal amplitude-stimulus intensity function. However, the first negative deflection exhibits a small difference of implicit time between the normal and affected eye. The normal eye does not show any pathological alteration.

Adult↗
PubMed1976

Visually evoked cortical potential (VECP) in dichromats.

The fundamental spectral sensitivity functions in man were studied by recording the visually evoked cortical potential (VECP). Using steadily presented strong blue-green and purple adaptation lights, two different spectral sensitivity functions were obtained with peaks in the green (540 nm) and in the red (590 nm) part of the spectrum. Only one peak (540 nm) was found in protanopia. The specific shift in deuteranopia and the influence of a blue-sensitive mechanism is discussed.

Color Vision Defects↗
PubMed1975

Role of Passavant's ridge in cleft palate speech.

In order to reevaluate the role of Passavant's ridge, 10 adult cleft palate patients with a marked ridge were examined by a radiographic and cineradiographic method. Following results were obtained: 1. Height of the ridge varies with the vowels. 2. Height of the ridge in consonant syllable phonation is not related to velopharyngeal closure required for each consonat but to the succeeding vowels. 3. Tongue position for vowel phonation has a great effect on the appearance of the ridge. In conclusion, formation of Passavant's ridge is not associated with the degree of velopharyngeal closure necessary for the specific speech sound, but it closely related to the tongue position for vowel production. Thus the significance of Passavant's ridge in cleft palate speech remains quite doubtful.

Adult↗