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Biomedical subjects

M Kessler

Publications and source records attributed to M Kessler.

At least 451 records · Page 25Linked to original sources

[Preoperative and postoperative stomach evacuation studies via methods of nuclear medicine and methods of roentgen cineradiography (author's transl)].

A combination of roentgen cineradiography and functional scintigraphy of stomach evacuation, taken with a gamma camera, was used for assessing the success of organ-conservative surgery of ulcers (selective proximal phagotomy with or without pyloroplasty). This confirmed earlier results to the effect that surgical failure is not indicated with any measure of certainty by any individual roentgenologic symptom. However, the evacuation function is closely correlated with the pattern of clinical and subjective complaints. In most of the cases, rapid postoperative stomach evacuation results in freedom from complaints. Pyloric stenosis and retention point to the failure of the operation via the negatively effected subjective feeling of well-being. Hence, special importance must be attached to functional scintigraphy with regard to meaningful studies of the course and postoperative condition of the patient.

Gastric Emptying↗

[Xeroradiography in the diagnosis of skeletal diseases (author's transl)].

The value of xeroradiography in the diagnosis of peripheral skeletal lesions is illustrated by some typical examples and compared with standard radiographic procedures. The advantages of xeroradiography depend on its convenient format, easy appreciation of structural changes and easy viewing. On the other hand, density gradations are flattened. Compared with a technically satisfactory film examination, there is no increase in diagnostic information. Xeroradiography can therefore only be regarded as complementary to conventional radiography for the diagnosis of skeletal conditions.

Bone Diseases↗

Action of norepinephrine on microcirculation and PO2 distribution in the isolated perfused rat liver.

The addition of a potent vasoconstrictor, such as norepinephrine, induces an influx of sodium and an efflux of calcium and potassium in the parenchymal cells of the perfused liver. This reaction can be reversed by the addition of dihydroergotoxine mesylate (active substance of Hydergine). The example shows clearly that very distinct biological signals are generated under such conditions at the membrane level of the hepatocytes and presumably of other cells of liver tissue. At present, our investigations cannot clearly answer the question of whether or not swelling the shrinkage of parenchymal cells and of endothelial cells can serve as an additional mechanism for regulating microcirculation.

Animals↗

[Improvement of the oxygen supply of the cirrhotic rat liver by selection of portacaval shunt method].

Intrahepatic disturbances of circulation following various portasystemic shunting procedures can be monitored by means of the Pt-multiwire surface electorde. The normal liver is capable of compensating for each degree of portal blood deprivation. In the presence of a thioacetamide-induced liver cirrhosis in the rat a side-to-side PCS significantly improves oxygen supply of the liver. Preserving residual portal perfusion of the liver by choice of different portasystemic shunts, the oxygen supply is slightly improved, too. This effect does not correlate with the quantity of residual liver perfusion, but is possibly due to vasocative hormonal substances, from a pancreatico-duodenal source, that regualte liver circulation.

Animals↗

High-affinity phlorizin binding to brush border membranes from small intestine: identity with (a part of) the glucose transport system, dependence on Na +-gradient, partial purification.

In the presence of an NaSCN gradient phlorizin binds with a high affinity (Kd similar or equal to 4.7 micron) to vesicles derived from brush border membranes of intestinal cells of rabbits. The value for Kd corresponds closely to that of Ki determined from phlorizin inhibition of sugar transport. The apparent affinity for phlorizin is decreased if NaCl is substituted for NaSCN and decreased substantially if the gradient of NaSCN is allowed to dissipate prior to the phlorizin binding. The number of high affinity binding sites is about 11 pmol/mg protein. Additional binding to low affinity sites can amount to as much as 600 pmol/mg protein after prolonged exposure to phlorizin (5 min.). The high affinity sites are related to glucose transport based on the similarity of the Kd and Ki values under a variety of conditions and on the inhibition of the binding by D-glucose but not by D-fructose. The transport system and the high affinity phlorizin binding sites can be enriched by a factor of 2-3 by treatment of vesicles with papain, which does not affect the transport system, but considerably hydrolyzes nonrelevant protein.

Animals↗

[Radiological bone patterns compared with pathological and anatomical appearances (author's transl)].

In the present study, radiographs of the skeleton were compared with relevant pathological sections; in this way some information could be more clearly brought out and changes in the structure and contours of bones could be classified. The radiographs were compared with photographs of the actual specimen. For this purpose either plain radiographs or tomographic cuts were used. In addition, bone sections were studied by a radiographic magnification method in order to improve detail recognition.

Bone Diseases↗

Oxygen tension in different tissues.

Our findings of studies in critically ill patients can be summarized as follows: 1) Adequacy of tissue oxygenation cannot be predicted solely from measurement of arterial blood Po2 since normal values may be associated with an inadequate tissue oxygen supply. 2) Measurements of global blood flow are in no way indicative of the distribution of blood flow within an organ and point to need for more specific monitoring within organs of both low distribution and metabolic activity.

Humans↗

Renal tissue oxygenation during hypoxic hypoxia.

No evidence was found to support the existence of changes in the intrarenal flow pattern among the different areas or of a compensatory redistribution of microcirculation in the renal cortex under hypoxia induced by breathing 10 % oxygen. It seems that under these conditions the kidney is able to preserve its basic metabolism by diminishing its oxygen consumption.

Animals↗

Interrelationships between orthodontics and periodontics.

At the present time, periodontists have no evidence to indicate that orthodontic treatment in the child will either enhance or detract from the periodontal health of the patient or that it will increase or decrease the longevity of the teeth. Many periodontists believe that much orthodontic treatment is undertaken on an esthetic or empirical basis. Proper emphasis on plaque control procedures prior to initial banding, altered and reinforced during the entire period of orthodontic treatment, may well minimize the inflammatory lesion often found during therapy. Gingival, periodontal, and mucogingival problems should be treated as soon as they are diagnosed. Limiting our orthodontic objectives in adult patients because of the possibility of inducing supporting alveolar bone loss and other problems that did not previously exist may be a worthwhile compromise. Orthodontic movement in periodontally healthy adults, and especially in those with periodontally involved teeth, constitutes a problem distinct from routine orthodontics. When periodontal disease has already produced significant destruction of supporting tissue and secondary occlusal trauma is a complicating factor, orthodontic treatment may possibly serve as another mode of treatment to reestablish the correct occlusal plane and alter bony deformities. Various methods can be used to try and place teeth into better bone. One should make certain that teeth are being moved into a greater volume of bone. The bite plane is of great value in allowing continuous eruption of the teeth and their supporting structures and in eliminating additional trauma by enabling the teeth to move into their correct cusp-fossa relationships unimpeded by the inclined planes of the opposing teeth. Since little is known about the interrelationships between orthodontic treatment and periodontal health and disease, there is still a great deal to learn. In spite of this lack of knowledge, the general practitioners and the various specialists of dentistry, each seeking a rationale for his preventive and therapeutic procedures, subject the patient to treatment based on concepts of the occlusion which have yet to be corroborated. In addition to the need for research in this field, a common language between the periodontist and the orthodontist must be established to eliminate the existing communications barrier. Once basic principles can be determined, elucidated, and applied correctly, the movement of teeth in periodontal cases will be limited only by the imagination of the operator.

Adult↗

[Urethro-cysto-colpo-rectography, a radiological method for the diagnosis of insufficiency of the pelvic floor (author's transl)].

Contrast examination of pelvic organs was carried out in 200 female patients with insufficiency of the pelvic floor. The topography of the organs in the true pelvis and their functional relation was recorded on full-size film and 70 mm. roll film. Radiological examination provides more accurate indications for plastic surgery of the pelvic floor, influences the operative procedures and permits better evaluation of operative results.

Contrast Media↗