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Biomedical subjects

M Kawashima

Publications and source records attributed to M Kawashima.

At least 361 records · Page 20Linked to original sources
PubMed1982

[Basic study on efficacy of cefmetazole against osseous and articular infections (author's transl)].

In order to evaluate the efficacy of cefmetazole (CMZ) against osseous and articular infections fundamentally, the sensitivity of clinically isolated strains of Staphylococcus aureus to the drug and its concentration in serum and bone marrow of tibia were determined. 1. The clinically isolated strains of S. aureus was found to be sensitive to 0.78 microgram-6.25 micrograms CMZ per milliliter when inoculated at 10(6) cells/ml and to 0.78 microgram-12.5 micrograms CMZ per milliliter when inoculated at 10(8) cells/ml. No strains were resistant to CMZ. 2. One gram of CMZ was injected intramuscularly before operation. Blood samples were collected from the bone marrow and the vein and measured for the concentration of CMZ. The mean concentration in the bone marrow of tibia were 30.5 microgram/ml, 16.8 micrograms/ml and 8.9 micrograms/ml 1, 2, and 3 hours later, respectively, and the mean transfer rate from serum to bone marrow was 104.8, 92.8 and 101.1% respectively. 3. CMZ concentration in bone marrow of tibia attained following an intramuscular injection of 1 g of CMZ were higher than the MIC values for most of the clinically isolated strains of S. aureus, suggesting the effectiveness of CMZ in clinical practice.

Ampicillin↗
PubMed1982

[Treatment and prevention of infections with cefoxitin sodium in patients with biliary tract infections and obstructive jaundice].

UNLABELLED: A total of 24 patients who was hospitalized in the Internal Medicine Wards of Yamaguchi University attached Hospital and the university's 3 related hospitals were administered with cefoxitin. The breakdown of the patients treated with cefoxitin was 7 with cholecystitis, 7 with choledochitis and the remaining 10 for the prevention of infections with obstructive jaundice. Daily doses of 2-6 g of cefoxitin were administered for 6-40 days by intermittent intravenous drip infusion in divided doses. RESULTS: 1. Of 14 patients with biliary tract infections, 10 (71.4%) responded favorably with cefoxitin. 2. Of 10 patients with obstructive jaundice used for the prevention of infections, 8 (80%) responded favorably with cefoxitin. 3. No untoward side effects were observed. 4. Cefoxitin proved to be a safe and effective antibiotic in the treatment of biliary tract infections and for the prevention of infections in patients with obstructive jaundice.

Adult↗
PubMed1981

Clinical features of 53 cases with pustulotic arthro-osteitis.

We have described clinical features of 53 cases with pustulotic arthro-osteitis. Anterior chest wall symptoms such as intersterno-costoclavicular or manubriosternal lesions were observed in all of 53 cases. Spondylitis or spondylodiscitis was found in 18 cases. Sacroiliitis resembling ankylosing spondylitis was seen in 7 cases. Peripheral inflammatory arthritis was seen in 14 cases, which were of nonerosive, of oligoarthritis type, and cured within 1 to 2 months, leaving no residue. HLA B27 was never found, and RAW factor was negative. Histological examinations revealed nonspecific chronic inflammation of bone and soft tissue. Pustulotic arthro-osteitis is apparently distinct from known rheumatic diseases such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and Reiter's disease. We have proposed that this condition should be classified as a member of the "seronegative spondylo-arthritis' group as designated by Wright and Moll.

Adult↗
PubMed1981

Incidence of arthro-osteitis in patients with pustulosis palmaris et plantaris.

Arthro-osteitis at the anterior chest wall was found in 12 (9.4%) out of 128 consecutive patients with pustulosis palmaris et plantaris. This finding indicates that the concomitance of arthro-osteitis with PPP is not incidental but is based on some common aetiological factor. We propose a term ;pustulotic arthro-osteitis' for this condition.

Adult↗
PubMed1981

Elevated levels of circulating carcinoembryonic antigen in hypothyroidism.

The level of circulating carcinoembryonic antigen (CEA) was measured in 148 patients with various thyroid diseases. A significantly high frequency of positive CEA was observed in hypothyroid patients with Hashimoto's disease, but the serum CEA levels were not correlated with the serum calcitonin concentrations in Hashimoto's disease. The CEA levels were inversely correlated with the serum T4 concentrations (P less than 0.001) and were positively correlated with the serum TSH concentrations (P less than 0.001), but not with the titers of serum antithyroid antibodies or the size of goiter in autoimmune thyroid disease. Moreover, the increase in CEA was significantly related to the duration of hypothyroidism (P less than 0.001). The high CEA levels in all hypothyroid patients decreased when the patients attained a euthyroid state after thyroid hormone therapy for 4-9 months. The gradual decrease in the serum CEA levels during treatment was roughly correlated with the decreases in serum cholesterol concentration and serum lactic dehydrogenase and glutamic oxalacetic transaminase activities. On Sephadex G-200 column chromatography of serum from hypothyroid patients, the CEA immunoreactivity, like purified standard CEA, was recovered in the large molecular weight fraction. These findings indicate that elevated CEA levels in hypothyroid patients do not necessarily indicate malignancy. CEA elevation in hypothyroidism may be caused by decreased degradation of CEA.

Adolescent↗
PubMed1981

Increase in plasma thyrotropin-releasing hormone in normal human pregnancy.

Maternal thyroid regulation in pregnancy was examined by measuring the concentrations of TRH, T4, T3, free T4 (by RIA), T4-binding globulin, TSH, PRL, and hCG in the sera of 30 normal pregnant women, 10 puerperally lactating women, and 10 normal pregnant women, 10 puerperally lactating women, and 10 normal nonpregnant female controls. Results showed that serum T4, T3, T4-binding globulin, PRL, and hCG, but not free T4 (by RIA), increased significantly during pregnancy. The plasma level of TRH was significantly higher (P less than 0.01) in the second trimester and significantly lower (P less than 0.05 1 month post partum than those values in nonpregnant controls. No significant correlations, however, were observed between the serum level of TRH and those of the thyroid hormones TSH, PRL, and hCG in pregnancy. The TRH-degrading activity of the plasma in the second trimester was normal. These results indicate that TRH secretion may be increased in the second trimester of pregnancy.

Adult↗