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Biomedical subjects

M Katz

Publications and source records attributed to M Katz.

At least 343 records · Page 19Linked to original sources

A longitudinal study of numbers of males and females in mental retardation services by age, IQ and placement.

A year-by-year analysis up to age 22 was carried out of the numbers of males and females in a birth cohort receiving mental retardation services in a British city. A slight excess of males was found during childhood, with the largest excess occurring at the upper end of the IQ range, the borderline area for classifying children as mentally retarded. There was also a large male excess found in residential care at each age. During the young adult years, this predominance of males in residential care was offset by an excess of females attending day care centres, leading to almost equality of numbers of males and females receiving some sort of services during this period. Possible explanations for the findings were discussed.

Adolescent↗

Survey of city/county public health agencies to determine the development, use, and effect of program performance standards.

For over 80 per cent of a national sample of local health agencies in the United States, minimum program standards are specified by the state, by law, regulation, or some other policy method. The performance standards that are used are a mix of state and local standards, with one-third of the agencies reporting that the Model Standards were used in developing their own standards.

Health Priorities↗

Anthelmintics. Current concepts in the treatment of helminthic infections.

This article discusses the anthelmintics now in common use and describes their mode of action and toxic side effects. The drugs reviewed include: pyrantel pamoate, mebendazole, piperazine, thiabendazole, niclosamide, praziquantel, niridazole, oxamniquine and diethylcarbamazine. Most of the common roundworm intestinal infections respond to treatment with pyrantel pamoate, which has the advantage of single-dose therapy. Trichuriasis requires therapy with mebendazole, while the filariases are treated with diethylcarbamazine. There is no specific therapy for trichinellosis, but its symptoms can be alleviated. Intestinal cestode infections respond to treatment with niclosamide and cerebral cysticercosis to praziquantel, but echinococcal hydatid disease still requires surgical intervention in certain cases, although prolonged treatment with mebendazole shows promise. The greatest recent advance in the therapy of helminthiases is the development of praziquantel which effectively treats the most severe of these infections.

Anthelmintics↗

Spironolactone in the treatment of hirsutism.

Spironolactone (100 mg) for 25 days in each menstrual cycle was assessed over 6 months for treatment of hirsutism in 35 patients. Five patients withdrew due to either nausea or polymenorrhea. the latter problem was encountered in 16 patients. Of the 30 remaining patients, 17 had a significant reduction in hair growth as assessed by Ferriman and Gallwey hair scores (p less than 0.05). The only significant change in endocrine parameters was a reduction in serum testosterone (p less than 0.05). Treatment with spironolactone alone was inferior to our previous experience with the cyproterone acetate--estrogen combination.

Female↗

Outcome of pregnancy in 110 patients with organic heart disease.

Organic heart disease is still one of the main causes of maternal and fetal mortality. The outcome of pregnancy in 110 patients with organic heart disease ranging from class I to IV (New York Heart Association Classification) was studied. The incidence of intrauterine growth retardation in the study group was examined with regard to severity of the disease. Birth weight was compared to that in a matched control group, and no statistically significant difference between the two groups was found.

Abortion, Spontaneous↗

Maternal perception of prelabor uterine activity.

Patient perception of uterine activity was assessed objectively in 44 women at risk for preterm labor using a tocodynamometer designed for ambulatory outpatient use. The monitor allowed patient-activated marking of the data whenever contractions were perceived. After instruction in self-detection of uterine activity, tocodynamometry was performed daily for 8.5 weeks per patient. Patients identified an average of 15% of their contractions during the study (range 0-78%). Numerous marks were placed in the absence of any detectable uterine activity. Of multiple obstetric variables analyzed, only multifetal gestation and preterm labor in the current pregnancy had any significant impact on perception. Results suggest that self-detection of uterine activity may not be reliable as the only means for the earliest possible detection of preterm labor.

Female↗

Detection of preterm labor by ambulatory monitoring of uterine activity: a preliminary report.

Effective tocolytic therapy depends on the ability to make an early diagnosis of preterm labor. This study was designed to assess whether daily ambulatory home monitoring of uterine activity could facilitate early diagnosis of preterm labor. Of 76 patients at high risk for preterm labor who used daily ambulatory tocodynamometry, approximately half developed preterm labor. Evaluation when the diagnosis of preterm labor was first established has shown that in 8% of the patients the cervix was dilated more than 2 cm, shortened to less than 0.5 cm in 23%, and the fetal membranes were intact in all subjects. The same evaluation in 76 nonrandom contemporary controls matched for risk factors, maternal age, and parity has shown that more than 50% had a cervix dilated more than 2 cm, 38% had a cervix shorter than 0.5 cm, and 24% had rupture of the fetal membranes. Ultimately, 88% of the monitored patients and 59% of controls delivered at term. Comparisons between these groups indicate that intermittent home tocodynamometry may indeed be useful in making the early diagnosis of preterm labor.

Ambulatory Care↗

Psoriasis vulgaris of labium majus.

A case of psoriasis vulgaris of the labium majus in a 22-year-old woman is described. The unusual presentation and other conditions that should be included in the differential diagnosis of this common disease are emphasized.

Adult↗

Sex differences in number of children administratively classified as mildly mentally retarded: an epidemiological review.

Many epidemiological studies of mental retardation have shown a higher prevalence of boys than girls. Data were reviewed from various studies consistently showing that the highest male/female ratios are found at the upper end of the IQ range for children classified as mentally retarded. One reason for this may be that boys with IQs at the upper end of this range have greater difficulty than girls in meeting the requirements of school performance. Factors that may cause boys to experience more difficulties than girls in the early school years were reviewed.

Child Development↗