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Biomedical subjects

M Kasai

Publications and source records attributed to M Kasai.

At least 595 records · Page 33Linked to original sources
PubMed1975

Differentiation of biliary atresia from neonatal hepatitis by routine clinical examinations.

After analysis of 33 cases of neonatal hepatitis and 90 cases of biliary atresia, a score test from history, physical findings and daily laboratory examinations was studied for the differential diagnosis of these two diseases. The biliary atresia takes plus score, whereas the neonatal hepatitis takes minus score. The score test is of great value for the differential diagnosis between these two diseases.

Alkaline Phosphatase↗
PubMed1975

An attempt to determine surgical indication for biliary atresia by laboratory examination.

To determine the surgical indication of biliary atresia, we analyzed the history, physical findings and laboratory examinations of 90 cases of biliary atresia operated upon at the Second Department of Surgery, Tohoku University Hospital during the past 10 years, from 1963 through 1972 inclusive. A score table from the data of these examinations was made for the determination of surgical indication. According to this score table, all of the patients who showed good excretion of bile took plus score, whereas a half of the patients who showed poor or no excretion of bile took minus score. Although the remaining patients who showed poor excretion of bile took plus score, these cases had some elements for good excretion of bile. From these results, the patients who takes plus score is considered to be a good indication for operation. The score test is of great value for determination of the surgical indication of biliary atresia.

Age Factors↗
PubMed1975

Reconstruction of intrahepatic bile ducts in congenital biliary atresia.

Macroserial reconstruction of the main intralobular bile ducts was made in 7 cases of biliary atresia; 2 cases of type I, 1 case of type II and 4 cases of type III according to Kasai's classification. From the results of these reconstruction studies, it was confirmed that the main interlobular bile ducts are usually patent through the liver regardless of the type of atresia of the extrahepatic bile ducts. A microserial reconstruction of bile ducts and ductules of a small portal tract performed in one case disclosed that a number of ductules make a network around the main duct and have some communications with the main duct. These results were compatible with the fact that active excretion of bile was obtained in many postoperative patients with biliary atresia. As observed in one case of the present series, postoperative complication of severe ascending cholangitis seemed to be an important cause of destruction or disappearance of intrahepatic bile ducts, which has also seen in older infants with this disease without complicaion of cholangitis. In view of these facts the operation of an early stage of life is recommended in biliary atresia.

Autopsy↗
PubMed1975

Malignant mixed tumor of the liver: report of a case and a review of the literature.

Malignant mixed tumor of the liver seen in a 4 year old girl was reported. Progressive hepatomegaly, jaundice, anemia, and extraordinarily high level of serum total cholesterol were noted clinically. Postmortem examination had disclosed that most part of the tumor was occupied by fibrosarcomatous cell growth admixed with rhabdomyosarcomatous component. In addition, carcinomatous component was distinctly recognized in a restricted part of the liver tumor. Previous reports on malignant mixed tumor of the liver were reviewed and it was emphasized that the histological diagnosis of malignant hepatic mixed tumor must be cautiously followed Edmondson's criteria; which requires existence of both epithelial and mesenchymal components of neoplastic nature and malignancy of either or both components in a hepatic tumor.

Carcinoma↗
PubMed1973

Reexamination of electrical stimulation on sarcoplasmic reticulum fragments in vitro.

The effect of direct electrical stimulation on suspensions of sarcoplasmic reticulum membrane fragments (SRF) was carefully re-examined using the method of Lee et al. (1966) J. Gen. Physiol. 49:689. Inhibition of Ca(++) uptake or release by electrical stimulation was observed. When platinum electrodes were used as stimulating electrodes, the effect was dependent on the total current passed through the suspension. On the contrary, when silver-silver chloride electrodes were used, no effect was observed even if voltage and current were the same as in the case of the platinum electrodes. In addition, apparent re-uptake of Ca(++) after cessation of electrical stimulation using platinum electrodes was shown to be due to a binding of Ca(++) to denatured SRF which did not require an energy supply such as ATP, although such re-uptake had been taken as strong evidence of electrical response of SRF in Lee's paper. Finally, it was concluded that the effect of electrical stimulation on SRF was attributable to the irreversible denaturation of SRF due to the oxidation caused by the chlorine generated at the platinum electrode.

Adenosine Triphosphatases↗