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Biomedical subjects

M Kanayama

Publications and source records attributed to M Kanayama.

At least 91 records · Page 5Linked to original sources
PubMed1987

Hypouricemia due to subtotal defect in the urate transport.

Hypouricemia due to renal tubular defects is rarely reported. We report here our observations of two such patients who cannot be classified into any of the previously reported categories of renal hypouricemia. They showed no suppression of urate clearance to creatinine clearance ratio (Cua/Ccr) following the administration of pyrazinamide, and no increase of Cua/Ccr after probenecid. It is tempting to speculate upon the subtotal defect in the urate transport as a condition explaining the above results.

Adult↗
PubMed1986

A case of hepatocellular carcinoma associated with ossification. A case report.

A 54-year-old man with hepatocellular carcinoma (HCC) of the typical trabecular pattern exhibiting unusual histologic features, both osteoid and bone formations, is reported. The tumor was associated with well-developed cirrhosis; thus, this may be different from mixed hepatic tumors of adults with bone formations because the latter are characterized by their prevalence in noncirrhotic livers and by the formation of myxoid connective tissue. Computed tomography of the current case revealed calcification within HCC.

Carcinoma, Hepatocellular↗
PubMed1986

Clinical investigation of vestibular damage by antituberculous drugs.

Vestibular function testing was done regularly on the cases given streptomycin, kanamycin, or enviomycin and a method to detect the cases of vestibular dysfunction at an early stage was discussed, as well as the time these drugs should be discontinued. Subjects were 85 cases of tuberculosis treated with streptomycin, kanamycin, or enviomycin who were admitted to our hospital from December 1984 to May 1986. The method of equilibrium examination performed at regular intervals is as follows: standing test (Romberg test), stepping test, and Meyer zum Gottesberge's head-shaking test were done once a week for a month after starting antituberculous injections and they were re-examined once every 2 weeks for at least 3 months after beginning the injections. After the 3 months these tests were done once a month. Eight cases of vestibular damage due to streptomycin or enviomycin could be easily detected at an early stage by performing Meyer zum Gottesberge's head-shaking test, together with the standing test and the stepping test. Vestibular dysfunction is apt to occur after about 1 month or within a month from the start of daily injections especially with streptomycin. Therefore, the method of equilibrium examination, we suggest, is that the Meyer zum Gottesberge's head-shaking test, the standing test (Romberg test), and the stepping test should be performed once a week during the first month after the start of this drug. When the result of the Meyer zum Gottesberge's head-shaking test is less than 50% and swaying and/or rotation occur in the stepping test, the drugs being given should be discontinued.

Aged↗
PubMed1985

Computed tomography of a diploic epidermoid cyst of the skull.

The computed tomographic (CT) and other roentgenological characteristics of a skull diploic epidermoid cyst in a 14-year-old boy with Ito syndrome, a neurocutaneous syndrome, are presented. When this boy was 3 years 10 months of age, a plain roentgenogram of the skull showed an area of decreased density in the left parietal bone. The area has grown for the subsequent 10 years plus and a characteristic sclerotic margin has become evident. CT examination showed a cystic lesion in the diploe, the outer third of high density and the inner third low density. CT allowed prediction of the operative and histological findings. It was useful not only for the diagnosis but also in the pathogenesis.

Adolescent↗
PubMed1985

Hypomelanosis of Ito associated with benign tumors and chromosomal abnormalities: a neurocutaneous syndrome.

A 14-year-old Japanese boy with hypomelanosis of Ito (HI) who has been followed up from the neonatal period is described. In addition to neurocutaneous symptoms consisting of intractable epilepsy, severe mental retardation, sensory neuropathy and cutaneous hypopigmentation, the following abnormalities were detected; a ventricular septal defect, a mature cystic teratoma in the posterior mediastinum, a diploic epidermoid cyst of the parietal bone and chromosomal abnormalities, i.e. mos, 45, XY, t(14q 21q)/46, XY, t(14q 21q)+mar. This disorder showed not only multisystem involvement but also tumor formation, which had not been reported previously. Because of this, it is better to use the term "Ito syndrome" instead of "HI" or "incontinentia pigmenti achromians (IPA)," which emphasize only the cutaneous symptoms.

Adolescent↗
PubMed1985

Echocardiographic and Holter findings in 321 uremic patients on maintenance hemodialysis.

Cardiac manifestations in 321 patients on chronic hemodialysis (dialysis duration of from 0.1 to 11.3 years) were examined with non-invasive technique. In contrast to the previous assumption that cardiac dilatation and pericardial effusion are common in patients on chronic hemodialysis, interventricular septal hypertrophy (51.3%) and left ventricular posterior wall hypertrophy (47.1%) on echocardiography and left ventricular hypertrophy (47.0%) on ECG were the most frequent abnormalities in these patients. Although premature beats on routine ECG were found in a limited number of patients (4.7%), ventricular premature beats were recognized in 45.7% and high grade arrhythmias in 27.2% of 92 patients examined with 24-hour Holter ECG monitoring. There were no high grade arrhythmias and the frequency of ventricular premature beats was 19.4% in 31 age-matched healthy subjects studied. Furthermore, the PQ interval was progressively prolonged in relation to the duration of hemodialysis. This finding may suggest that long-term hemodialysis is associated with disturbances of the conduction system. These results indicate that myocardial hypertrophy and high grade arrhythmias are the prominent findings in uremic patients maintained on hemodialysis. We consider that such high grade arrhythmias could be responsible for a high incidence of cardiac death in these patients.

Adolescent↗