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Biomedical subjects

M Kaibara

Publications and source records attributed to M Kaibara.

At least 109 records · Page 6Linked to original sources
PubMed1983

[Effect of gestational diabetes on erythrocyte aggregation].

In order to elucidate the tendency to erythrocyte aggregation in gestational diabetes, blood viscosity at a standard hematocrit of 45% (corrected viscosity) was measured at low shear rates in the third trimester of normal pregnancy and pregnancy with gestational diabetes. The mean values (+/- S.D.) for corrected viscosity of 20 gestational diabetic patients were 69.2 +/- 16.6cp at shear rate of 0.11 sec-1, 34.9 +/- 5.3cp at 0.54sec-1 and 27.9 +/- 5.0cp at 0.99sec-1. They were significantly higher than those of 40 normal pregnant patients (55.2 +/- 11.4cp at 0.11sec-1, 29.0 +/- 2.6cp at 0.54sec-1 and 24.4 +/- 2.4cp at 0.99sec-1). The mean value of fibrinogen of gestational diabetic patients was 408.8 +/- 106.7 mg/dl and significantly higher than that of normal patients (313.3 +/- 65.1 mg/dl). The increased tendency to erythrocyte aggregation observed in the diabetic patients was due to increased fibrinogen and would induce microcirculatory disturbance and mild hypoxia in the placental tissue. The cytotrophoblastic cell proliferation which is a characteristic morphological finding of diabetic placenta would be induced as a result of the reaction of placental tissue to the hypoxia thus produced.

Alpha-Globulins↗
PubMed1982

[Management of fetuses in the late pregnancy by serial determinations of serum human placental lactogen levels].

Serum human placental lactogen levels (HPL) were measured serially during the last three weeks before full term deliveries of 69 normal and 60 high risk pregnant women with the method of latex agglutination (Gestefollow 'Eiken'). Except pregnancies complicated with diabetes mellitus, no fetal distress were observed when deliveries were made while HPL levels were increasing. The incidence of fetal distress was only 3.7 per cent when the range of variation of HPL levels was within 20 per cent for 3 weeks before delivery. On the contrary, the incidence of fetal distress increased to 29.4 per cent when infants were delivered after decreasing of HPL levels to less than 80 per cent of the highest HPL levels. It was also demonstrated that single determinations of HPL levels were not clinically useful in predicting fetal distress or fetal growth retardation.

Female↗
PubMed1981

[Clinical studies on flow properties of blood in the gynecological patients with potentially hypercoagulable state (author's transl)].

The flow property of blood, the blood viscosity was measured under such gynecological conditions that were potentially hypercoagulable: in the post-operative state for myoma uteri corporis, in the use of oral contraceptives and in the advanced stage of malignant uterine and ovarian tumors. The viscosity was measured at a shear rate of 0.989 sec-1 and at 37 degrees C. Blood viscosity after operation rose to 15.6 +/- 3.7 cp (mean +/- SD), which was significantly higher than that of pre-operative state (12.4 +/- 3.7 cp). This was due to increased hematocrit and fibrinogen levels. The viscosity returned to preoperative level on the 3rd day of post-operation. The blood viscosity of users of oral contraceptives was 15.1 +/- 2.7 cp, not being significantly higher than that of control women (13.4 +/- 2.8 cp). The blood viscosity of patients suffered from malignant tumors was 10.5 +/- 2.0 cp and was significantly lower than that of control. Comparison of viscosity at the same hematocrits revealed, however, that the viscosity of patients of malignant tumors was significantly higher than that of control. Such rheological characteristics in the patients of malignant tumors were due to decreased hematocrit and markedly increased fibrinogen levels. It was suggested that dehydration and infection should be avoided to prevent thrombus formation in the gynecological patients with potentially hypercoagulable state.

Adult↗
PubMed1980

Voltage pulsation of sickle erythrocytes enhances membrane permeability to oxygen.

Treatment of sickle red cells (SS homozygous) with a voltage pulse of less than 0.8 kV/cm and duration of 20 mus caused a change in the cell membrane, so as to facilitate the permeation of oxygen. The unsickling of the treated cells after a re-introduction of oxygen took place at a much faster rate. Neither leakages of Na+ and K+, nor a change in the cell volume occurred as the result of the low voltage pulsation. The effect of the voltage treatment persisted for hours at 25 degrees C but disappeared rapidly at 37 degrees C. The result suggests that a selective modification of membrane permeability may be achieved by the voltage pulsation technique.

Anemia, Sickle Cell↗
PubMed1980

[Studies on the rheological characteristics of fetal blood (author's transl)].

Viscosity of fetal and adult blood was measured and compared. The viscosity was measured with a Contraves viscometer at a low shear rate of 0.535 sec(-1). There was no significant difference in the mean value of viscosity between fetal and adult blood. The viscosity of the adult blood showed the time dependent change when measured at the constant shear rate, but fetal one showed no such change. The mixture of adult plasma and fetal red blood cells (hematocrit: 50%) showed the same rheological characteristics as that of adult. On the contrary the mixture of fetal plasma and adult red blood cells showed the rheological characteristics of fetal blood. When the adult blood was observed under microscope numerous rouleaux of red blood cells were observed. However fetal blood showed numerous dispersed red blood cells and only a few poor rouleaux of red blood cells. It was suggested that the rheological characteristics of fetal blood was due to the fetal plasma which contained lower concentrations of fibrinogen and globulin, and which prevented the red blood cells aggregating to form rouleaux.

Adult↗
PubMed1977

Effect of temperature on dynamic viscoelasticity during the clotting reaction of fibrin.

The dynamic rigidity and loss moduli for fibrinogen-thrombin solution were determined during clotting in the temperature range between 15 and 45 degrees C. The rigidity of fibrin gel decreased with increasing clotting temperature, owing to the dissociation of cross-links. The rate constant of the dissociation of cross-links increased with increasing temperature. The rate constant of the cross-linking reaction increased and then decreased through a maximum with increasing temperature. It is explained by assuming that denaturation of fibrin occurs at high temperature. The irreversible denaturation becomes appreciable at high ionic strength. The activation energy and the enthalpy change for the cross-linking reaction of fibrin is about 35 and 15 kcal/mol, respectively. The enthalpy change for the reversible denaturation is about 46 kcal/mol.

Animals↗