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Biomedical subjects

M Jones

Publications and source records attributed to M Jones.

At least 1,027 records · Page 57Linked to original sources
PubMedDate not supplied

The effect of acute ethanol consumption on the human retinal circulation: a study in diabetic and non-diabetic subjects.

The effects of acute ethanol consumption on retinal haemodynamics and retinal vascular autoregulation to oxygen in the human retinal circulation were studied in 10 diabetic (mean age +/- SD: 38.2 +/- 11.1) and 16 non-diabetic (mean age +/- SD: 32.4 +/- 8.8) subjects. Subjects drank 0.5 g of ethanol, as vodka, per kg of body weight, diluted in sugar-free orange juice. Retinal blood flow was determined using laser Doppler velocimetry and computerised image analysis. The effect of ethanol on oxygen reactivity, as a measure of autoregulation, was also determined after 60% oxygen inhalation. All subjects demonstrated a significant fall in mean arterial blood pressure (control group 3.3%, p = 0.04, diabetic subjects 5.7%, p = 0.05), after ethanol intake. Ethanol caused no significant change in retinal blood flow. Oxygen reactivity was found to be 38.3% (22.4-47.7, median and interquartile range) in the non-diabetic subjects at baseline, and 30.7% (10.8-42.1) after ethanol ingestion. In diabetic subjects, the oxygen reactivity was 33.2% (19.8-46.8) at baseline and 24.5% (21.1-32.1) after ethanol. In this study ethanol did not significantly affect retinal blood flow or impair autoregulation. These results suggest that the retinal circulation may be able to autoregulate despite the presence of ethanol, in contrast to other vascular beds where ethanol changes flow.

Adult↗
PubMedDate not supplied

Anomalies of the brain and congenital heart disease: a study of 52 necropsy cases.

During routine autopsy examinations several macroscopic anomalies of brains were noted in children with congenital heart disease (CHD). To define these observations 52 autopsies of cases with CHD as well as 52 controls were compiled. Cases were divided into two groups according to the absence (group I) or presence (group II) of a multimalformative syndrome (MMS). Fifty percent of the sample was associated with MMS. Brain anomalies were classified into grades I, mild and focal; II, intermediate, focal or diffuse; and III, severe and diffuse. Group I was associated with brain anomalies (mainly of grades I and II with altered gyri) in 19 of 28, whereas in Group II the brains frequently had compromise of lobes, gyri, and fissures, 18 of 24. The relationship between the types of CHD, grade of brain anomalies, and MMS is delineated. The high frequency of brain anomalies associated with CHD but without other malformations (67.8%) suggests a clinical counterpart of these lesions.

Adolescent↗
PubMedDate not supplied

Polycystic kidney disease: an unrecognized emerging infectious disease?

Polycystic kidney disease (PKD) is one of the most common genetic diseases in humans. We contend that it may be an emerging infectious disease and/or microbial toxicosis in a vulnerable human subpopulation. Use of a differential activation protocol for the Limulus amebocyte lysate (LAL) assay showed bacterial endotoxin and fungal (1-->3)-beta-D-glucans in cyst fluids from human kidneys with PKD. Fatty acid analysis of cyst fluid confirmed the presence of 3-hydroxy fatty acids characteristic of endotoxin. Tissue and cyst fluid from three PKD patients were examined for fungal components. Serologic tests showed Fusarium, Aspergillus, and Candida antigens. IgE, but not IgG, reactive with Fusarium and Candida were also detected in cyst fluid. Fungal DNA was detected in kidney tissue and cyst fluid from these three PKD patients, but not in healthy human kidney tissue. We examine the intertwined nature of the actions of endotoxin and fungal components, sphingolipid biology in PKD, the structure of PKD gene products, infections, and integrity of gut function to establish a mechanistic hypothesis for microbial provocation of human cystic disease. Proof of this hypothesis will require identification of the microbes and microbial components involved and multifaceted studies of PKD cell biology.

Communicable Diseases↗
PubMedDate not supplied

Dressing wounds.

This article describes the choice and method of application of wound dressing in a variety of situations. The types of wounds covered include those in awkward areas, cavity wounds and fungating wounds. The problems of patients with allergies to wound dressings are also discussed.

Bandages↗
PubMedDate not supplied

Wound debridement: evaluating the costs.

Debridement is the technique used to remove slough and necrotic tissues that can prevent or delay wound healing. The authors compare the published evidence on the speed and cost-effectiveness of larval therapy with that of more conventional dressings used to promote autolytic wound debridement.

Animals↗
PubMedDate not supplied

Step by step.

Explore the source record for details and available documents.

Drug Prescriptions↗
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Special interest.

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Community Health Nursing↗
PubMedDate not supplied

Exploring men's health in a men-only group.

This article looks at one attempt to allow a particularly vulnerable group of men, those in contact with mental health services, to explore men's health issues in a men-only group environment. Based on an examination of current literature on men's health issues and feedback from participants in the group sessions, the authors suggest that nursing should rethink its position on the issue of men's health.

Gender Identity↗
PubMedDate not supplied

Larval therapy.

Larval therapy--the use of maggots as a form of wound care--has been shown to be an effective and fast way to treat some wounds. This article describes how this method can be used successfully in practice.

Aged↗
PubMedDate not supplied

Proposed extensions to nurse prescribing.

Nurse prescribing has been a bone of contention for the past decade. Now, the government seems willing to discuss some radical possibilities.

Drug Prescriptions↗
PubMedDate not supplied

The patient no one liked.

Despite professional admonitions to treat patients with dignity and to promote their well being, there are some patients who are unpopular with or not liked by nurses. Caring for these patients presents an ethical challenge for nurses. The purposes of this article are to explore the issue of bias and the use of labels, as well as the subsequent ethical concerns of respecting the uniqueness of the patient and preventing harm when nurses have a negative bias toward and label particular patients. The authors discuss several implications for nursing practice, including engaging in introspection, understanding the "problem" patient, actively involving patients in their care, and evaluating strategies used to eliminate negative bias and labeling.

Agonistic Behavior↗