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Biomedical subjects

M Jonas

Publications and source records attributed to M Jonas.

At least 91 records · Page 5Linked to original sources
PubMed1989

Sterol-mediated suppression of HMG-CoA reductase mRNA levels in cultured cells requires protein synthesis.

The mRNA levels for HMG-CoA reductase were measured in Chinese hamster lung Dede cells or ovary CHO cells by Northern blot analysis. It was observed that 25-hydroxycholesterol decreased the level of reductase mRNA by 40 to 70% in a 6 hour treatment. Inclusion of cycloheximide in the culture prevented the decrease observed with 25-hydroxycholesterol alone. Pretreatment of cells with 25-hydroxycholesterol for 6 hours prior to cycloheximide addition reveals that the protein synthesis inhibitor can return the suppressed levels of reductase mRNA back to control levels. Thus, protein synthesis is required for 25-hydroxycholesterol dependent suppression of HMG-CoA reductase mRNA.

Animals↗
PubMed1982

The tetracyclines.

Tetracyclines continue to be used extensively on a world-wide basis because of their unusually broad antimicrobial spectrum and their relative safety. The first generation tetracyclines are used almost exclusively via the oral route; the second generation tetracyclines may be used orally or intravenously. Intramuscular administration is not recommended. Doxycycline is preferred in the treatment of upper respiratory tract infections, atypical pneumonias, intraabdominal/pelvic sepsis or trauma, venereal diseases, and in the treatment of prostatitis. Minocycline is preferred for meningococcal prophylaxis, central nervous system infections (due to susceptible organisms), and in staphylococcal infections (when tetracycline is indicated).

Bacteria↗
PubMed1982

Patient behavior in hospitals: helplessness, reactance, or both?

Forty-eight inpatients hospitalized for 1, 3, or 9 weeks and 24 outpatients were tested on cognitive tasks: poor performance and depressive symptoms increased with length of hospitalization, even as illness resolved. Further, increased hospitalization made patients more susceptible to the debilitating effect of uncontrollable events. Taken together, these results imply that the passive, compliant, and inanimate behavior of the "good patient" may be the result of learned helplessness engendered by hospitalization.

Adult↗
PubMed1982

Bacteremic Escherichia coli pneumonia.

Nine patients with bacteremia Escherichia coli pneumonia were studied, and 22 cases from the literature of the bacteremic and nonbacteremic variety were reviewed. The findings of this study indicate that E coli pneumonia most often occurs in persons who are elderly and have associated conditions that impair host defenses. Escherichia coli pneumonia is usually nosocomially acquired. The organism may reach the respiratory tract by aspiration of oropharyngeal secretions due to colonization or by hematogenous dissemination from a primary source in the gastrointestinal tract or the genitourinary tract. The clinical manifestation most often is that of pneumonia in the lower lobe, but the process can be roentgenographically variable. Sputum culture is usually positive in the bacteremic form of E coli pneumonia. The high morbidity found in this study, despite appropriate antimicrobial therapy, emphasizes the need for earlier recognition and infection prevention in predisposed groups.

Adult↗
PubMed1982

Minocycline.

Minocycline, a second generation tetracycline derivative, was first introduced in 1967. The following review considers the physiochemical and pharmacokinetic properties, antimicrobial activity, clinical uses, and adverse effects of minocycline. Excellent tissue and secretion penetration due to its higher lipid solubility, good broad spectrum activity, superior gastrointestinal absorption, decreased alteration of the fecal flora, and prolonged half-life, are properties that make minocycline a unique antimicrobial agent. Despite these exceptional characteristics, minocycline remains an infrequently used agent because of the availability of alternate drugs and the vestibular dysfunction associated with its administration.

Animals↗
PubMed1981

Sleep-wake pattern in preterm infants under two different care schedules during four-day polygraphic recording.

The sleep-wake pattern of healthy preterm infants under two different schedules of routine procedures was studied by 4-day polygraphic-recording. Group-I experienced the usual routine care conditions, Group-II remained less disturbed by means of time-coordination of the procedures. Group-II-infants were less awake, showed a higher percentage of active sleep and the undisturbed phases of active and quiet sleep were longer than in Group-I-infants. Routine procedures left Group-II-infants more often in an unchanged state than Group-I-infants, the latter exhibiting an arousal reaction more frequently. The unknown effect of sleep disturbances in preterm-infants demands a reduction and coordination of routine procedures as far as possible.

Arousal↗
PubMed1975

[Thrombolytic therapy in arteriosclerotic disease (authors transl)].

The treatment of acute arterial occulsion, especially emboli and also thromboses associated with a complete ischaemia is the domain of the surgeon. Subacute or chronic arterial occlusion -- uni- or myltilocular --are suited for a trial of thrombolytic therapy, with an approximate success rate of 40%. When thrombolysis is contraindicated, then transluminal dilatation according to Dotter can be attempted in cases of short stenosis. A new and successful indication for thrombolysis is in the therapy of cases of late reocclusion after vascular reconstructive operations. The preliminary results in this field are very good, especially in the aortoiliac region. The indications, the practical details, the results and complications of thrombolytic therapy with streptokinase are discussed.

Acute Disease↗
PubMed1975

[Rare case of an adult teratoma of the stomach (author's transl)].

The teratoma is a dysgenetic tumor consisting of tridermal differentiation products. The most common classification is made according to maturity - benign adult teratoma and malign nonmature embryonal teratoma. In the case demonstrated, a 15-year-old male suffers from tiredness, paleness and pains in the epigastrium. The radiological examination showed a tumor in the size of a fist with a number of teeth located partly within the stomach. The histological findings after operation confirmed the diagnosis of a coetaneous (= adult) gastric teratoma. The discussion shows that all cases of gastric teratoma published until 1972 are male, in 77% under the age of 1 year, in 13% under the age of 10, and only in 10% over the age of 10 years.

Adolescent↗