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Biomedical subjects

M Jeanmougin

Publications and source records attributed to M Jeanmougin.

At least 73 records · Page 4Linked to original sources
PubMed1983

[Familial portuguese type amyloid polyneuropathy. Attempt at a pathogenetic interpretation].

The pathogenesis of familial portuguese amyloid polyneuropathy, a form of hereditary peripheral neuropathy is at present uncertain. Our hypothesis is that there may be a genetic modification in the metabolism of the Schwann cell. Normally this cell produces myelin, however with genetic modification perhaps it could switch its production to the protein precursor for amyloid. Therefore, the abnormality would reside primarily in the nervous tissue with the amyloid deposits being secondary but contributing to the axonal degeneration.

Amyloid↗
PubMed1983

[Phototoxic activity of 5% benzoyl peroxide in man. Use of a new methodology].

In order to conform to the conditions in which a 5% benzoyl peroxide compound is being used, a new methodology has been developed and applied to 24 volunteers: photobiologic tests were performed and UVB irradiation at infra- and supra-MED times of exposure as well as UVA irradiation on usually covered and usually uncovered areas, after single and multiple applications. This double-blind study (vehicle alone and active substance alone) has been carried out in each subject. UVB phototoxicity resulted in the occurrence of an erythema for an infra-MED time of exposure and/or in changes in the erythema as compared to an adjacent control area for the supra-MED time of exposure. This was found in 8 patients (33%), only on repeatedly irradiated areas, but never with the vehicle alone. No UVA phototoxicity was evidenced. This study confirms the possible phototoxic action of benzoyl peroxide after UVB exposure. It emphasizes the usefulness of repeating the applications on both covered and uncovered areas in photosensitivity tests of a substance.

Benzoyl Peroxide↗
PubMed1982

[Detection and incidence of hepatitis in secondary syphilis. Seventy case-reports (author's transl)].

Biologic hepatitis is common in secondary syphilis. Six cases are reported, in which stereotyped biologic changes were found. These consisted of very high alkaline phosphatase levels and gamma GT levels, with definite inflammation. Cytolysis was moderate or absent. Diagnosis can be established when these biologic anomalies are associated with strongly positive serologic tests for syphilis and rapid recovery under adequate treatment. In these cases, hepatic biopsy is unnecessary.

Hepatitis↗
PubMed1981

[Mascaró's eccrine syringofibroadenoma. Discussion of a case].

The authors report a case of eccrine syringofibroadenoma. The only difference with the original cases as described by Mascaró in 1963 is that it contains only a few glandular structures. The histologic pattern is also similar to that of the acrosyringeal naevus recently described by Weedon and Lewis, so that it seems needless using a new terminology: these tumors can be considered as examples of eccrine sytingofibroadenoma.

Biopsy↗