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Biomedical subjects

M Jeanmougin

Publications and source records attributed to M Jeanmougin.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Value of the light-test histological study in photodermatoses].

Clinic and histologic analysis of 92 phototests of various photodermatosis (14 benign summer light eruption (BSLE), 47 polymorphous light eruption (PMLE) 20 persistent light reactor photodermatitis (PLRP), 11 drug induced photodermatitis (DIP) has been performed. Clinically, a phototoxic aspect was observed in 30 cases, it was photoallergic in 36 cases and uncertain in 26 cases. Histologically, a phototoxic picture was present in 32 cases, a photoallergic one in 48 cases, and 12 cases exhibited unclassified aspect. Only one case of BSLE was associated with photoallergic aspect, clinically and histologically. Photoallergic type was observed in 70 p. 100 of iterative exposure phototest (IEP) of PMLE; clinical and histological aspects were concordant; in contrast phototoxic aspects were constantly observed when single exposure phototest (SEP) were used. In PLRP histological aspect of IEP was constantly of photoallergic type; whereas clinical aspect was uncertain in 50 p. 100 of the cases; 7 of the 10 biopsies of SEP exhibited a photoallergic picture. In DIP histological aspect of IEP was constantly photoallergic, whereas 5 of the 6 cases exhibited uncertain clinical aspect; only one of the 5 SEP gave a photoallergic reaction both clinically and histologically. Comparison of histological features revealed a more typical photoallergic picture in PLRP than in PMLE. We conclude that: the reproducibility of clinical and histological lesions is better with the iterative exposure phototest than with single exposure phototest; histologic examination is more reliable than clinical findings in persistent light reactor photodermatitis and drug induced photodermatitis.

Humans↗
PubMed1984

[Determination of urinary xanthurenic acid after oral loading of L-tryptophan in 88 cases of photodermatosis].

Disturbances in the kynurenine pathway are present in pellagra and pellagroid syndromes. In 88 photodermatoses, the authors found increased urinary excretion of xanthurenic acid after oral load of tryptophan in a number of light-induced eruptions, i.e. benign summer photodermatosis (40%), polymorphous light eruptions (37%), and persistent light reactions (36%) as well as in patients with acute alcoholic intoxication. These biochemical abnormalities in the kynurenine pathway allow for a pathogenetic approach in some photodermatoses.

Administration, Oral↗
PubMed1984

[Non-drug toxicoderma by a respiratory or probable percutaneous route (fluorocarbons, butane, phenyl-azo-beta-naphthol)].

Four cases of cutaneous rash, clinically more or less similar to erythema multiforme have been observed in patient who either stayed in a room with an accidentally high content of fluorocarbons, or had a skin contact with butane or phenyl-azo-beta-naphthol. The cutaneous lesions appear to be secondary to absorption of the toxic product, and probably induced by inhalation rather than by percutaneous penetration. Arguments for the responsibility of the substances rely on anamnestic data.

Adult↗
PubMed1984

[Photoallergy to quinine].

A case of occupational photodermatitis induced by quinin sulphate is reported. Photobiologic investigation disclosed the responsible photoallergin, demonstrated the mechanism to be of the photoallergic type, and proved the active rays to be mostly UVA. It seems that we do not deal with a contact photodermatitis, but with an internal photosensitization induced by absorption or inhalation of quinin powder and possibly excreting during sweating.

Drug Compounding↗
PubMed1984

[Factitious crusting cheilitis].

The authors report 4 cases of factitious crusting cheilitis seen in young women. The lesions are crusty, yellowish or even black, forming as a mould casting the lip. The crusts are sometimes very thick just as an oyster-shell. When removed the underlying mucosa appears either normal or erosive and the crusts reappear rapidly. Emotional factors and personality disturbances are often present. Most probably the crusts are the result of a traumatic mechanism induced by chewing or sucking the lip. In the 4 reported patients the clinical aspect and the psychological status of the patients are similar, the 4 of them being not at all bothered by their cheilitis. The factitious keratotic cheilitis has to be differentiated from other cheilitis induced by Candida albicans (although Candida albicans may superinfect any cheilitis) or by an actinic phenomenon, from glandular cheilitis (of the Puente-Acevedo or of the Volkmann type) and from dermatitis localized on the lips. In some instances an exfoliative cheilitis may also to be of factitious origin. The factitious origin of such a cheilitis is always difficult to demonstrate but its possibility should be kept in mind.

Adolescent↗
PubMed1984

[Sandy nails and twenty-nail dystrophy of childhood. Apropos of 2 cases].

2 apparently idiopathic cases of twenty-nail dystrophy of childhood are reported with follow-ups of 4 and 16 years, respectively. The associated koilonychia appears to be only fortuitous and related to the fragility of the nail. Trachyonychia should be considered as a symptom often related to external traumatism or dermatoses, particularly alopecia areata or lichen planus, of which it could be a specific isolated location. Within the spectrum of apparently idiopathic trachyonychies , the twenty-nail dystrophy of childhood appears to be a real entity on the basis of its clinical features and course.

Adolescent↗
PubMed1984

[Hypocomplementemic urticarial vasculitis with glomerulopathy and renal venulitis].

A 58 year-old woman had atypical chronic urticaria, arthralgias and abdominal pain. Attacks of angioneurotic edema occurred. Proteinuria was discovered. She had clinical and biological signs of inflammation, leukoneutropenia , antileukocyte antibodies and low CH 50, C1q and C4 levels without functional C1 esterase deficiency. C1q precipitins were not detectable. Skin biopsy disclosed angiitis and by immunofluorescence a lupus band test was positive. Serologic investigations in search of SLE were negative. Renal biopsy showed mesangial deposits, capillary loop thickening and mesangial fixation of anti-IgG, C3 C1q and C4 antisera. In the interstitium, voluminous perivenular inflammatory infiltrates were visible. With corticosteroid treatment clinical manifestations subsided and proteinuria disappeared. This observation of McDuffie 's angiitis with renal venulitis leads to a review of the literature with discussion of the mechanisms of hypocomplementemia.

Biopsy↗
PubMed1983

[Pemphigus].

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Adolescent↗
PubMed1983

Nail dyschromia.

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Antimalarials↗