Reflex effects of carotid body chemoreceptor stimulation on the heart rate of the rabbit.
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Biomedical subjects
M J Scott
Publications and source records attributed to M J Scott.
The effects of hyperventilation on the reflex cardiac response from the carotid bodies in the cat.
1. Cats were anaesthetized with chloralose and urethane, and ventilated by an artificial intermittent negative pressure applied to the thorax. The carotid body chemoreceptors were isolated and perfused with oxygenated blood. They were stimulated by substituting hypoxic blood obtained from a donor animal.2. Stimulation of the carotid bodies during constant ventilation caused a bradycardia. When an artificial hyperventilation was induced during carotid body stimulation the heart rate increased.3. The increase in heart rate during hyperventilation, and while the carotid bodies were being stimulated, was due to at least two mechanisms, first a reflex from the lungs and secondly a fall in arterial blood P(CO) (2), both of which accompany the hyperventilation.
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In vitro exposure of murine macrophages to ultraviolet light induces apoptosis.
Ultraviolet light is a known exogenous stimuli with the ability to activate cell death by apoptosis. This study was done to examine the biologic effects of different energy levels of short wavelength UV light on cultured mouse macrophages. Cell proliferation, DNA content, and cellular ultrastructural architecture analysis demonstrated that ultraviolet light induces apoptosis in murine macrophages in culture. Exposure to 0.12J/cm2 evokes progressive cell demise with the classical features associated with apoptosis, whereas exposure to 5.0 J/cm2 results in extensive DNA degradation and crosslinking of cellular proteins. These two phenotypes are qualitatively described.
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