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Biomedical subjects

M J Mannis

Publications and source records attributed to M J Mannis.

101 records · Page 6Linked to original sources
PubMedDate not supplied

Keratoplasty: a historical perspective.

Replacement of the dysfunctional cornea was an idea originating in the 18th century. The 19th century was a period of intense experimentation with various forms of keratoplasty. This work bore fruits in the early 1900s when the successful penetrating homograft was realized. Since that time, advances in surgical techniques and method of tissue preservation, as well as a greater appreciation of corneal immunobiology, have made keratoplasty a readily available surgical alternative.

Animals↗
PubMedDate not supplied

William Ellergy Briggs: pioneer of west coast ophthalmology.

William Ellergy Briggs was California's preeminent ophthalmologist for more than fifty years. A student of Ernst Fuchs, he was a clinician, scholar, and innovator who transplanted the best of European ophthalmology to the Western United States.

California↗
PubMedDate not supplied

Refracting the corneal graft.

Patients who have undergone penetrating keratoplasty have unique postoperative refractive requirements. These include irregular astigmatism, high corneal toricity, and anisometropia. We present a stepwise clinical approach for accurate, efficient refraction of these patients, utilizing visual acuity measurement, retinoscopy, subjective refraction, keratometry, photokeratoscopy, and diagnostic rigid contact lens application.

Humans↗
PubMedDate not supplied

Lectin receptors in the human cornea.

Five different biotin labeled lectins, Concanavalin-A (Con A), wheat germ agglutinin (WGA), Ricinus communis agglutinin I (RCA1), Ulex europaeus agglutinin (UEA1), and soybean agglutinin (SBA) were used to study lectin receptors on formalin-fixed paraffin embedded human corneas. Con A stained the cytoplasm, cell, and nuclear membranes of the epithelial cells and stained the stroma diffusely. WGA stained the superficial epithelial cells, the epithelial cell membranes, and the keratocytes of the stroma. SBA did not react with any of the corneal layers. RCA1 heavily stained the keratocytes but did not stain the epithelium. UEA1 lightly stained the epithelial cell cytoplasm and interstitial stroma. All staining reactions could be abolished by omission of the lectin or by the use of the appropriate inhibitory sugar. The lectin binding patterns reported here provide a means for further investigation of carbohydrate structures in the human cornea in both normal and disease states.

Cornea↗
PubMedDate not supplied

Hydrophilic contact lenses for wound stabilization in keratoplasty.

Hydrophilic contact lenses may be used in selected cases in which penetrating keratoplasty is complicated by partial wound dehiscence and anterior slippage of the donor tissue. We report five cases and describe a technique in which, rather than resuturing, a soft contact lens is used as a corneal stent to realign the graft-host interface. This technique allows for non-surgical correction of a potentially serious complication, with preservation of good vision during the treatment period. In the present series, no serious complications were encountered, and all wounds were adequately reapposed. Successful application of this technique requires appropriate patient selection and careful monitoring during the course of treatment.

Adult↗