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Biomedical subjects

M J Kelly

Publications and source records attributed to M J Kelly.

At least 199 records · Page 11Linked to original sources
PubMed1981

Multigated equilibrium radionuclide angiocardiography: improved detection of left ventricular wall motion abnormalities and aneurysms by the addition of the left lateral view.

The usefulness of adding the left lateral (LLAT) view to the standard anterior and left anterior oblique views in multigated equilibrium radionuclide angiocardiography was assessed in 50 patients. Contrast ventriculography was used as the standard. Receiver operating characteristic (ROC) curve analysis was used to assess results. Recognition of inferior wall motion abnormality and left ventricular aneurysms was improved significantly by the addition of the LLAT view. Sensitivity was improved for inferior wall motion abnormality and for aneurysms; there was no loss of specificity. There was no improvement in recognition of anterior wall and apical regional abnormalities in the absence of aneurysms.

Adult↗
PubMed1981

Preparation of a Mastership thesis.

A detailed account is given of the mechanics of converting the manuscript results from a period of research into a thesis that is also a first-class, readable book.

Academic Dissertations as Topic↗
PubMed1981

An analysis of the effects of apomorphine and haloperidol on the release of [3H]-dopamine and [3H]-noradrenaline from rabbit brain slices.

The effects of apomorphine and haloperidol on the K+-induced release of [3H]-dopamine from striatal slices and [3H]-noradrenaline from cerebellar slices were examined. Apomorphine (0.01-1 microM) reduced the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline from cerebellar slices unaffected. A higher concentration (10 microM) of apomorphine increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Haloperidol (0.01-1 nM) increased the K+-induced release of [3H]-dopamine from striatal slices, leaving the K+-induced release of [3H]-noradrenaline unaffected. Haloperidol in higher concentrations (10-100nM) increased significantly the K+-induced release of [3H]-noradrenaline from cerebellar slices. Both compounds inhibited the uptake of [3H]-dopamine into striatal slices and [3H] noradrenaline into cerebellar slices. In low concentrations both compounds showed selectivity for dopaminergic receptor sites, apomorphine stimulating and haloperidol inhibiting pre-synaptic dopamine receptors. Higher concentrations of these compounds showed a non-selective action.

Animals↗
PubMed1980

Hyperpolarization of hypothalamic parvocellular neurons by 17 beta-estradiol and their identification through intracellular staining with procion yellow.

Intracellular recordings and injections of procion yellow (PY) were made in parvocellular neurons in hypothalamic slices of female guinea pigs. Eighty-five neurons, with an average resting membrane potential of -35 mV, were recorded in the arcuate (ARC) ventromedial (VM), and in the cell-poor zones between the ARC and VM. Eleven of the ARC neurons and four neurons from the cell-poor zone could be driven antidromically by median eminence (ME) stimulation, nine other neurons from the three areas could be driven orthodromically by stria terminalis (ST) stimulation. Twenty-eight parvocellular neurons were tested with 17 beta-estradiol (E2), which was applied in the bathing medium as the free steroid. Eleven neurons (nine ARC and two cell-poor-zone neurons) were hyperpolarized 2 to 24 mV by 10(-10) M E2 concentrations. 10(-8) M estrone concentration was without effect on three of these cells. Through the intracellular injection of PY, the estrogen-sensitive neurons (N = 11) were identified as small fusiform cells with few dendrites. Spine-like appendages were found on only one of these cells. None of the larger pyramidal-like neurons of these areas responded to the application of E2.

Animals↗
PubMed1980

Single unit recordings in the rat pineal gland: evidence for habenulo-pineal neural connections.

Extracellular potentials were recorded in the pineal gland of urethane-anesthetized rats. Two distinct populations of excitable pineal "cells" were found, the silent "cells" which were driven by habenula stimulation and the spontaneously active cells. In the former case 17 of the responses (median latency of 1.2 ms) showed a positive-negative potential, and 6 (about 1 ms latency) showed only positive potential of 1-2 ms duration. The remaining cells (114), which could not be driven by habenula stimulation, exhibited spontaneous activity with a firing frequency from less than 1 Hz to greater than 100 Hz with a median firing frequency of 10 Hz. These experiments clearly demonstrate a direct habenulo-pineal fiber pathway and furthermore show that there are neuronal elements in the pineal which are only activated by habenula stimulation.

Animals↗
PubMed1980

Psychiatric consultation among hospitalized arthritis patients.

Fifty consecutive psychiatric consultations on 48 patients over an 18-month period in an arthritis hospital are analyzed. The range of psychiatric disorders and their relationship to characteristics of the patient population, such as age, sex, and medical diagnosis, are described. Approximately 2% of patients admitted to the hospital during this period elicited psychiatric consultation. This rate is one-third of the consultation rate of an acute medical and surgical hospital serviced by the same consultants. The relative distribution of psychiatric diagnoses--depression 59%, personality disorders and drug abuse 15%, psychosis 10%, conversion reaction 10%, and "other" 6%--was similar to that encountered in an acute general hospital setting. Although depression was the most prevalent psychiatric problem, it was severe enough to elicit consultation only in 1% of the total hospitalized population; its severity did not correlate directly with the severity of rheumatoid arthritis, the most common medical diagnosis encountered. Neither a particular medical illness nor sex accounted for a disproportionate share of the psychiatric consultations.

Adolescent↗
PubMed1980

The radionuclide assessment of left ventricular function using graded exercise in normal subjects.

In 20 normal volunteers, two minute equilibrium gated blood pool scanning (GBPS) was used to assess left ventricular function during rest and three stages of graded supine exercise on a bicycle ergometer. The three work loads were individualised for each subject from a previously performed exercise test and corresponded to mild, moderate and severe stress. The short imaging time was validated against standard GBPS. With exercise all subjects increased their left ventricular ejection fraction and in the majority, most of this rise occurred with the lowest work load. This change was predominantly due to a marked fall in end-systolic volume. The end-diastolic volume initially fell, then at peak exercise returned to baseline values. The major change in stroke volume occurred at peak exercise.

Adult↗
PubMed1979

Transynaptic transport of procion yellow in the central nervous system.

Intracellular recordings were performed in slices of the lateral geniculate body, the visual cortex, and the hippocampus of guinea pigs. After recording, Procion Yellow was iontophoretically injected. During the injection period the neurones were activated antidromically and/or transynaptically. Up to 6 h after dye injection slices were fixed in a buffered formaldehyde/sucrose solution and later histologically processed. In the lateral geniculate body, after orthodromic stimulation across the optic tract, optic tract fibers were stained secondarily. Orthodromic activation across intrageniculate connections led to secondarily stained geniculate neurones. In the visual cortex orthodromic activation of the injected neurones across white matter led to secondarily stained fibres travelling in the direction to the white matter or to secondarily stained neurones in the vicinity of the injected neurone. In the hippocampus anti- and orthodromic activation across the alveus or the mossy fibre pathway led to a secondary staining of neighbouring pyramidal neurones and to a secondary staining of fibres which where afferent to the injected neurone. All slices where Procion Yellow was detected in the extracellular space were rejected. These findings led to the conclusion that Procion Yellow must have been transported across chemical synapses from the post- to the presynaptic side. The transport occurred only if the concerned synapses were activated.

Animals↗
PubMed1979

Morphological features of physiologically identified hypothalamic neurons as revealed by intracellular marking.

In the in vitro slice preparation intracellular recordings and injections of procion yellow (PY) were made in neurons of the hypothalamus. Of these neurons, one medial preoptic-anterior hypothalamus (MPO-AH) and four arcuate-ventromedial hypothalamus (ARC-VM) neurons were driven by electrical stimulation of the median eminence area (ME). Two other MPO-AH and five other ARC-VM neurons were driven by stimulation of the stria terminalis (ST). On the basis of the PY injections two morphologically distinct cell types were delineated: a larger multipolar cell type with a polygonal perikaryon was found with equal frequency in the MPO-AH and the ARC-VM. A smaller fusiform cell type was encountered mainly in the ARC-VM. On the secondary dendrites of both cell types spine-like appendages were seldom seen, but dendritic swellings were common. Some of the dendrites projected to capillaries in both areas and presumably contacted them. The axons were usually tortuous and could only be traced a short distance.

Animals↗