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Biomedical subjects

M J Harrison

Publications and source records attributed to M J Harrison.

At least 289 records · Page 16Linked to original sources
PubMed1978

Neurological manifestations of Paget's disease.

The neurological features of 96 patients whose skull and spinal X-rays showed the features of Paget's disease of bone were reviewed. The clinical phenomena were compared with those in another group of patients, identified by having a normal skull X-ray. Cranial nerve lesions and spinal syndromes could be attributed to the Paget's disease in many cases but the evidence did not suggest that other clinical phenomena such as dementia and epilepsy were related to the bony changes. Amongst cranial nerve lesions deafness is certainly attributable to Paget's disease, hemifacial spasm when combined with other signs is probably related, and possibly also trigeminal neuralgia. Basilar invagination can be asymptomatic, but deafness, hemifacial spasm and pyramidal signs were more prevalent in its presence. The importance of reviewing the cause and effect relationship between Paget's disease and neurological problems is discussed in the context of the therapeutic use of calcitonin.

Aged↗
PubMed1978

Subarachnoid hemorrhage and papilledema due to a cervical neurilemmoma. Case report.

An unusual case of a cervical neurilemmoma is presented. A 67-year-old man developed papilledema on two occasions in association with the symptoms and signs of a subarachnoid hemorrhage (SAH). He proved to have an otherwise asymptomatic cervical neurilemmoma. It is suggested that both acute and subclinical bleeding from such tumors may sometimes underlie the development of raised intracranial pressure occasionally encountered. The clinical clue to the spinal origin of the SAH was an acute onset with root pain. This case is discussed with reference to similar cases in the literature.

Aged↗
PubMed1977

The finding of thrombus at carotid endarterectomy and its relationship to the timing of surgery.

The clinical, angiographical, operative and histological records of 52 patients undergoing carotid endarterectomy for transient cerebral ischaemic attacks were reviewed. Thrombus or other friable material was present in 66 per cent of the 24 patients operated upon within 4 weeks of a clinical attack, but in only 21 per cent of the 28 patients in whom the time interval was longer. The data favour an embolic explanation for the clinical episodes and further suggest that thrombus formation on atheromatous stenosis and ulceration is intermittent.

Adult↗
PubMed1977

Evidence of silent cerebral embolism in patients with amaurosis fugax.

In 34 patients who presented with attacks of amaurosis fugax with no evidence of cerebral involvement, EEG, angiographic, and regional cerebral blood flow studies were carried out. Six of 23 EEGs, one of 21 angiograms, and five of six regional blood flow studies were thought to provide evidence of silent cerebral embolism. The implications for the management of patients who present with isolated amaurosis fugax are discussed.

Adult↗
PubMed1976

Inhibition of ADP-induced platelet aggregation by adenosine tetraphosphate.

In contrast to previous reports, highly purified adenosine tetraphosphate (AP4) does not induce the aggregation of platelets but inhibits the aggregation and release reaction in platelet-rich plasma promoted by ADP. The inhibitory action of AP4 on the aggregation by ADP is compared with that of AMP and ATP. The data presented suggest a competitive manner of inhibition of the ADP-induced aggregation by AP4.

Adenine Nucleotides↗
PubMed1976

Angiographic appearance of carotid bifurcation in pateints with completed stroke, transient ischaemic attacks, and cerebral tumour.

The angiographic appearance of the carotid bifurcation was compared in groups of patients aged 50-59 suffering from transient ischaemic attacks (40 cases), cerebral infarction with completed stroke (44 cases), and cerebral hemisphere tumour (66 cases). Carotid occlusion was found in 14% of those with infarcts and 5% of those with transient ischaemic attacks. Carotid stenosis was found in 40% of those with ischaemic attacks and 14% of those with infarcts. Minor irregularity of the carotid arterial wall was equally common in all three groups.

Angiography↗
PubMed1976

The neuropathic factor in the aetiology of diabetic foot ulcers.

The nature and severity of changes due to peripheral neuropathy has been assessed clinically and electrophysiologically in 39 diabetic patients, 23 of whom had penetrating ulcers on the sole of the foot. Patients suffering from diabetic foot ulcers were found to have sensory loss to pin prick in the feet more frequently than "controls". The electrophysiological measurements confirmed the severity of the neuropathy with absent sural nerve action potentials in 95% of the ulcer patients and inexcitability of small foot muscles in 40%. Weakness of small foot muscles due to neuropathy is thought to underlie the foot deformity that leads to maldistribution of weight bearing, and subsequent pressure necrosis of analgesic skin.

Action Potentials↗
PubMed1976

A double-lumen tube connector.

A connector for double-lumen tubes, that is simple and safe, is described. There are no separate attachments that may be lost and it is easily dismantled for sterilisation.

Anesthesia, Endotracheal↗