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Biomedical subjects

M J Harrison

Publications and source records attributed to M J Harrison.

At least 271 records · Page 15Linked to original sources
PubMed1980

Accuracy of carotid angiography in the assessment of atheroma of the internal carotid artery.

In a post-mortem study to determine the accuracy of angiography in defining atheromatous disease of the origin of the internal carotid artery, 64 carotid bifurcations were filled with a mixture of gelatin and contrast medium, X-rayed, cleared for pathological study, and assessed by a neurologist and a vascular surgeon. Agreement between the two observers on the X-ray appearances was 87.5% and between the agreed X-ray interpretation and the macroscopic pathological findings 78.6%. Closest agreement was seen with normal and stenosed vessels. Difficulties were encountered with lesser changes due to plaques and ulceration. Since the decision to recommend carotid endarterectomy in patients with a history of transient ischaemic attacks depends on the angiographic findings, knowledge of the accuracy of angiography can be critical.

Arteriosclerosis↗
PubMed1980

The role of autonomic neuropathy in diabetic foot ulceration.

In an attempt to define the role of autonomic neuropathy in the pathogenesis of diabetic foot ulcers, we have studied diabetic patients with and without ulcers, and a group of non-diabetic controls. A series of standard autonomic function tests have been compared with measurement of the Galvanic Skin Response (GSR). Patients with foot ulcers showed evidence of more severe somatic and autonomic neuropathy than diabetic subjects with no ulcer. The GSR was found to correlate well with the more conventional tests. In addition it proved to be abnormal more often than any other test for autonomic neuropathy in the diabetic patients with foot ulcers. In a preliminary follow-up study 2 patients with an abnormal GSR but no ulcer at the time of testing have subsequently acquired plantar ulcers. It is suggested that the GSR may prove to be a useful means of detecting diabetic patients at risk from foot ulceration.

Adult↗
PubMed1980

I.v. flunitrazepam and i.v. diazepam in conservative dentistry. A cross-over trial.

In a randomized cross-over trial in 82 outpatients aged 15-45 yr undergoing conservative dentistry, a solution of flunitrazepam 0.25 mg ml-1 i.v. (average dose 0.014 mg kg-1) was compared with a solution of diazepam 5 mg ml-1 i.v. (0.29 mg kg-1). Cardiovascular changes, operating conditions and side-effects were similar. Forty minutes after the start of injection, about 85% of all patients could not remember the local anaesthetic injection. Thirty minutes after the end of treatment, only 25% of all patients had recovered. One week later, most patients receiving each drug had only vague memories of their treatment; they had felt more relaxed immediately after the i.v. injection than before. Drowsiness was equally common after flunitrazepam and diazepam. Ataxia was more prolonged with flunitrazepam but arm pain and venous thrombophlebitis were less frequent.

Adolescent↗
PubMed1980

Controlled study of 24-hour ambulatory electrocardiographic monitoring in patients with transient neurological symptoms.

Sixty unselected patients with transient neurological symptoms underwent 24-hour ambulatory electrocardiographic (ECG) monitoring. Haemodynamically significant arrhythmias were observed in 32% of patients, but in only 3% of an age- and sex-matched control group. Nine patients received specific anti-arrhythmic therapy, which resulted in marked symptomatic improvement in each case. It is argued that 24-hour ECG monitoring is a valuable diagnostic tool in the investigation of transient neurological symptoms.

Adolescent↗
PubMed1980

Clinical distinction of cerebral haemorrhage and cerebral infarction.

The clinical features of 62 cases of computerized axial tomography scan-proved cerebral haemorrhage and 81 cases of cerebral infarction in the carotid territory have been compared in a retrospective case note survey. The clinical features which can help in making the distinction between haemorrhage and infarction at the bedside are discussed and compared with those of classical teaching which referred only to post-mortem proved cases.

Adult↗
PubMed1979

Multi-infarct dementia.

Fifty-two patients presenting with dementia were divided into a group in whom clinical features suggested an ischaemic basis (multi-infarct dementia) and a group in whom a primary degenerative process seemed more likely. Focal EEG changes and angiographic evidence of ischeamic areas and atheromatous disease of intracranial vessels were more common in the "ischaemic" than in the primary degenerative group. CBF was significantly reduced in the former but the regional pattern was equally distorted in the two groups. These findings strengthen the belief that the ischaemic score can identify those patients whose dementia is associated with vascular disease.

Adult↗
PubMed1979

The normal fundus.

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Fundus Oculi↗
PubMed1979

Optic atrophy.

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Humans↗
PubMed1979

Chronic subdural haematoma.

A retrospective case note survey of chronic subdural haematomata was carried out in an attempt to throw some light on the difficulties encountered in clinical diagnosis. The combination of raised intracranial pressure headache, fluctuating drowsiness and mild hemiparesis, although highly suggestive of subdural haematoma, is not always encountered, and epilepsy, aphasia, hemianopia and dense hemiplegia can all occur contrary to 'text book' descriptions. Head injury or other aetiological factors are commonly absent. The presentation may mimic tumour, dementia, cerebrovascular accident or subarachnoid haemorrhage. Non-invasive investigations may yield false negative results, although in the case of radionucleide scanning and computerized axial tomography the reliability is approaching 90 per cent. The diagnosis will, however, remain an unexpected finding at angiography in a percentage of cases.

Adolescent↗
PubMed1979

Papilloedema.

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Diagnosis, Differential↗
PubMed1978

Relevance of duration of transient ischaemic attacks in carotid territory.

A retrospective review of the clinical and angiographic features of 116 patients who had had one or more transient ischaemic attacks in the carotid territory showed that stenosis of ther cervical portion of the internal carotid artery was significantly more prevalent among patients whose attacks had been brief, with full recovery in under one hour. This information may be helpful in selecting patients for angiography.

Adult↗