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Biomedical subjects

M J Flaherty

Publications and source records attributed to M J Flaherty.

At least 19 recordsLinked to original sources
PubMed1992

Multicystic pancreatic hamartoma: a distinctive lesion with immunohistochemical and ultrastructural study.

A multicystic pancreatic hamartoma is reported in a 20-month-old female who presented with abdominal pain and distention. This appears to be a distinctive lesion not previously characterized in the English language literature. The 9-cm mass consisted of large, irregular lobules of well-formed pancreatic acini admixed with fibrous tissue and fat. Cystically dilated ducts of variable caliber lined by benign epithelium were present. Endocrine cell islets were not evident. Immunohistochemistry and ultrastructural examination illustrated insulin-producing cells diffusely throughout the exocrine tissue as single cells or in small groups. Cells producing other pancreatic hormones were markedly decreased when compared with an age-matched control pancreas and were similarly dispersed. The patient was alive and well without tumor 9 months later. This entity may provide an unusual opportunity for insight into pancreatic organogenesis and pancreatic cellular differentiation.

Female↗
PubMed1992

Family styles of coping in end stage renal disease.

The introduction of a serious life-threatening illness such as end stage renal disease (ESRD) is an added stress dimension to the already enormous demands placed on the contemporary family system. The purpose of the present study was to identify qualitatively and describe selected aspects of psychosocial adaptation among the families of ESRD patients experiencing four primary modes of dialytic therapy: incenter hemodialysis, home dialysis, continuous ambulatory peritoneal dialysis (CAPD), and continuous cyclic peritoneal dialysis (CCPD). Five family coping styles emerged from content analysis of the data collected from 50 family members at four time periods. These styles have been labelled: Remote Family Style, Enfolded Family Style, Altered Family Style, Distressed Family Style, and Receptive Family Style.

Adaptation, Psychological↗
PubMed1990

Helping ostomy patients back to independence.

Because elderly ostomy patients must deal with numerous challenges, be sure to identify their strengths and enhance their self-esteem. When teaching the older adult, remember factors that may affect learning, such as sensory changes, slowed reaction time, decreased short-term memory, and motivation. Consider the effects of other chronic illnesses and medications when developing a routine for ostomy care, and be sure to discuss dietary considerations with the patient.

Aged↗
PubMed1990

Placental anticoagulant protein-I: measurement in extracellular fluids and cells of the hemostatic system.

Placental anticoagulant protein-I (PAP-I), a member of the lipocortin protein family, is a potent in vitro anticoagulant whose in vivo function is unknown. Very low levels of PAP-I were present in plasma of normal volunteers (0 to 5 ng/ml) and in randomly chosen plasma specimens from hospitalized patients (0 to 28 ng/ml). Review of selected hospital records did not reveal any single clinical entity that correlated with plasma levels. PAP-I was also found in amniotic fluid (12 to 107 ng/ml) and in conditioned medium of cultured endothelial cells (49 +/- 20 ng/ml). Gel filtration experiments showed that PAP-I was intact and uncomplexed in plasma and amniotic fluid. The protein was fairly abundant intracellularly: 4080 +/- 2560 ng/mg total protein in cultured umbilical vein endothelial cells; 178 +/- 109 ng/mg in platelets; 564 +/- 384 ng/mg in leukocytes; and 8.4 +/- 4.3 ng/mg in erythrocytes. The levels of PAP-I increased in platelet-rich plasma after stimulation of platelets with arachidonic acid but not after stimulation with ADP, epinephrine, thrombin, ristocetin, or collagen. These data suggest that PAP-I probably does not function as a circulating natural anticoagulant in normal persons.

Amniotic Fluid↗
PubMed1989

Iatrogenic immunization with bovine thrombin: a mechanism for prolonged thrombin times after surgery.

Unexplained very-prolonged thrombin times (greater than 300 s) were found in plasma from four patients. Other coagulation variables were normal, and there was no history of coagulopathy. Mixing studies suggested the presence of thrombin inhibitors in patient plasma. Substitution of human thrombin for bovine thrombin in performing the thrombin time test resulted in normal clotting times, indicating that the inhibitory activity was directed primarily against bovine thrombin. Each patient had been treated with topical bovine thrombin during previous surgery. In the one patient with a preoperative thrombin time, the initial value was normal and prolongation began 16 days after surgery. An enzyme-linked immunoassay showed elevated levels of IgM or IgG antibodies to bovine thrombin in each patient tested. Affinity-purified antibodies to bovine thrombin from patient serum prolonged the thrombin time of normal plasma. These results suggest that iatrogenic immunization by intraoperative exposure to bovine thrombin is responsible for antibodies to bovine thrombin, which accounts for the prolonged thrombin times found in some patients after surgery.

Adolescent↗
PubMed1989

Analysis of the market driven nursing shortage.

Donley and Flaherty look anew at the nursing shortage; they explain why the supply-side orientation cannot explain or resolve the problem. The mere increase in our numbers is not a solution in today's complex care environment. The authors explain the market-driven shortage and the changes in the work environment essential for ameliorating the shortage.

Allied Health Personnel↗
PubMed1988

Seven caring functions of black grandmothers in adolescent mothering.

Exploration of the involvement of Black grandmothers (N = 12) in the primary infant care activities of young adolescent mothers is the focus of this descriptive study. Seven categories of "grandmother caring functions" are identified from an analysis of interview data: managing, caretaking, coaching, assessing, nurturing, assigning, and patrolling. The importance of the grandmother in the functioning of the low-income extended Black family and the maternal role process of the adolescent mother is discussed.

Adolescent↗
PubMed1987

Grandmother functions in multigenerational families: an exploratory study of black adolescent mothers and their infants.

This qualitative study explores the functions of 19 Black grandmothers who are engaged in the care of their adolescent daughters' infants. Interviews with grandmothers revealed seven functions related to this role: managing, caretaking, coaching, assessing, nurturing, assigning, patrolling. Suggestions for future research with Black grandmothers are given.

Adolescent↗