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Biomedical subjects

M Ishaq

Publications and source records attributed to M Ishaq.

65 records · Page 4Linked to original sources
PubMed1980

A morphological study of the lungs and bronchial tree of the dog: with a suggested system of nomenclature for bronchi.

The bronchial tree was investigated in 37 pairs of lungs of adult dogs using dissection and corrosion techniques. The external morphology of the lungs and their lobes has been described. The right lung was divided by deep fissures into four lobes, the apical, the middle, the diaphragmatic and the intermediate. The left lung was found to have three lobes, the apical, the middle and the diaphragmatic. The left apical and middle lobes were partially fused, being separated only by an incomplete (cranial) fissure where either of the two lobes may overlap the other. This study has confirmed the existence in the dog's lungs of 'the stem bronchus' described by Aeby (1880). Each of the lobes of dog's lungs was served by a single bronchus which has been termed the 'lobar stem bronchus' and which extended as an axial stem from the hilus to a particular end of the lobe designated as the 'distal end'. In each lobe two main series of branches and accessory branches have been described. In each main series three types of branches have been described--normal, large, and small. A system of designating the bronchi has been suggested and used. The lobar stem bronchi often bifurcated after a variable number of branches had been given off. The total number of branches arising from the lobar stem bronchus, the number in each main series, the number of accessory branches, and the sequence of origin varied to the extent that no two bronchial patterns were found to be identical. The complexity of establishing a bronchopulmonary segmental pattern in the dog has been discussed.

Animals↗
PubMedDate not supplied

Detection and characterization of circulating immune complexes in peptic ulcer.

BACKGROUND: Immunological factors have been implicated in the pathogenesis of peptic ulcer following the demonstration of autoantibodies against IgA in patients with this disease. We investigated whether circulating immune complexes were present in this condition, and what type of immunoglobulins were involved. METHODS: The sera of 37 patients with duodenal ulcer and 8 with gastric ulcer were tested for the presence of circulating immune complexes using the polyethylene glycol (PEG) assay and the results compared with those in 79 controls. The precipitate was dissociated and the levels of IgA, IgG and IgM estimated using the single radial immunodiffusion technique. Simultaneous estimation of these immunoglobulins in the serum was also done. Autoantibodies against IgA in the serum were tested using the ELISA test. RESULTS: Eleven patients (6 with duodenal ulcer and 5 with gastric ulcer) were found to have circulating immune complexes. The mean protein content of the PEG precipitates was significantly higher in patients than in control subjects (p < 0.001). The mean values of all the immunoglobulin isotypes were higher in patients than in controls. The IgA content in the PEG precipitates of positive cases was higher than that in control subjects (p < 0.05). CONCLUSION: Patients with peptic ulcer have circulating immune complexes which may interfere with normal immunoregulation.

Antigen-Antibody Complex↗
PubMedDate not supplied

Immunogenicity of detergent membrane proteins of Entamoeba histolytica.

The lymphokine release and antibody production were assessed in the peripheral blood of 52 and 48 cases of amoebic liver abscess respectively, by employing detergent dissected membrane proteins (DDMP) of axenic Entamoeba histolytica (NIH:200). Lymphokine release by T lymphocytes in response to both DDMP and whole amoebic lysate (WAL) was performed by leukocyte migration inhibition test. A highly increased release of LMIF and 100 per cent positivity was observed with DDMP where as the same for whole amoebic extract, was only 73 per cent. The difference between the means of the above two values with regards to release of LMIF, was found to be highly significant (P less than 0.005). Antibodies production in response to both DDMP and whole amoebic lysate was performed by indirect haemagglutination assay on blood samples from amoebic liver abscess cases. A 53 folds increased titres of IHA and cent percent positivity was observed with DDMP compared to WAL. The difference between mean titres of the above two with regards to detection of antibodies, was found to be highly significant (P less than 0.001). This shows that the patients, had high degree of leukocyte sensitization and production of antibodies which will not be assessed simply with WAL. These findings suggest that the shed material might have important role as a potent antigen in elicitation cell mediated and humoral immune response in amoebic liver abscess cases.

Animals↗