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Biomedical subjects

M Isacsohn

Publications and source records attributed to M Isacsohn.

At least 37 records · Page 2Linked to original sources
PubMed1983

Surveillance of congenital rubella and the immunity status to rubella in the Jerusalem area.

A retrospective study on the incidence of congenital rubella (CR) in the past 10 years in the Jerusalem area was conducted. After the 1972 epidemic, which resulted in 48 cases of congenital rubella, few sporadic cases of CR appeared each year, and in the 1978-79 period the number of CR cases was relatively small. Immunity to rubella in different categories of population (children 3 months to 18 years, college students, nurses in pediatric, newborn and intensive care units, student nurses, and women of childbearing age) was determined by hemolysis in gel (HIG) and hemagglutination inhibition (HI) methods. Susceptibility was defined as an absence of antibody at a dilution of 1:16 in HI, and hemolysis of less than 7 mm in the HIG test. Compared with previous studies on the incidence of antibodies to rubella in women of childbearing age, a mild decrease in the percentage of sero-negative women was found.

Adolescent↗
PubMed1983

Unusual presentation of Bruton's agammaglobulinemia--Pseudomonas sepsis.

A case of Pseudomonas sepsis and meningitis is described in a family in which the first child died in the first year of life after a fulminant Pseudomonas sepsis. In our patient, the second son, treatment was begun immediately after admission with clinical and bacteriological signs of Pseudomonas sepsis and continued for a 4-week period. Subsequent cessation of the treatment resulted in a relapse, with meningeal involvement. After specific therapy was added for his immunologic incompetence, as well as subsequent antibiotic treatment, the patient was cured of his prolonged illness.

Agammaglobulinemia↗
PubMed1982

Persistent neonatal hypoglycemia due to hyperinsulinism: medical aspects.

Eight neonates with persistent hypoglycemia were seen over a four-year period and a ninth infant with neonatal onset was treated from 9 months of age. Seven infants had high absolute insulin levels (range 12 to 50 microunits/ml) during hypoglycemia whereas two patients had normal levels which were, however, inappropriate for the low blood glucose levels. Six patients with severe intractable hypoglycemia resistant to intensive medical therapy (including high dose diazoxide) had partial or total pancreatectomy, whereas three with relatively controllable hypoglycemia eventually had spontaneous remissions. In one of the medically treated patients, remission occurred at the unusually early age of 4 months. In the six surgically treated patients and in a seventh patient who had a biopsy only, the pancreas showed characteristic pathologic changes compatible with those described as nesidioblastosis or "endocrine-cell dysplasia." Of the six patients followed up for greater than or equal to 24 months, four have normal psychomotor development, despite periods of arrested head growth in early infancy in three of them.

Female↗
PubMed1979

Rubella in Jerusalem. 2. Clinical and serologic findings in children with congenital rubella.

Forty-eight children born with clinical and serologic manifestations of congenital rubella were followed for a three-year period. Expanded rubella syndrome, multiple anomalies and single defects were found, mostly in the child's first year of life. Some new organic problems were found at a later age in children who had initially been healthy but who had been followed up because of their high antibody levels to rubella. Of the 48 children, 15 (31%) were born to mothers who had had clinically and serologically diagnosed rubella during pregnancy. In 33 children (69%) the mother had had asymptomatic rubella. These findings emphasize the need to identify and immunize seronegative women before pregnancy.

Abnormalities, Multiple↗
PubMed1978

Rubella in Jerusalem. 1. Seroepidemiologic findings in children born after the 1972 rubella epidemic.

Nine hundred and sixty-nine babies born after a severe rubella epidemic were tested at the age of eight months for the presence of hemagglutination inhibition antibodies to the disease. There were 208 (21.9%) seropositive babies with titers of greater than or equal to 1:16. Seven cases of congenital rubella were diagnosed at birth, 14 were confirmed by eight months and two babies, who were considered normal at the age of eight months, developed late signs of the disease. Less than 3% of the mothers of the seropositive babies had had clinically recognized rubella in pregnancy. If positive hemagglutination inhibition antibody to rubella accurately reflects congenitally acquired rubella infection, between 8.1 and 21.9% of the 969 babies had serologic evidence of the disease. For cases of congenital rubella diagnosed by the age of three years, the limits are between 8.9 and 23.7 per 1,000 live births for the risk of the disease at the height of the epidemic. Rubella vaccine was not available in Israel until after the 1972 epidemic, the effects of which justify the continued search for and immunization of seronegative women of childbearing age, in addition to routine immunization of young girls.

Adult↗
PubMed1976

Congenital annular constrictions due to amniotic bands.

Amniotic bands which become involved with fetal parts, especially the extremities, are produced by rupture of the amnion during pregnancy with the consequent union of the extra-embryonic mesoderm in fibrous strings. An infant with the amniotic band syndrome, in whom an annular constriction of the left leg and right hand was found, is described. He was treated successfully by multiple Z-plasties and a plaster cast to correct the clubfoot. The oedema of the leg persisted for 5 weeks and then subsided completely. The role of amniotic abnormalities in the production of congenital malformations is reappraised. The microscopic and histological investigation of the placenta and membranes should accompany every case of fetal malformation in abortuses, stillbirths, and affected newborn.

Abnormalities, Multiple↗
PubMed1975

Anti-PP1Pk (anti-Tja) and habitual abortion.

Blood group incompatibility as a cause of early or habitual abortion has been a matter of much debate. However, the abortion rate in such cases is much higher than that found in the general population. Two sisters having the rare genotype pp and anti-PP1Pk (anti-Tja) in their serum were reported as having habitual abortions; a third sister, with a normal P group, had a normal obstetric history. The relationship of anti-PP1Pk (anti-Tja) to the high rate of habitual abortion was discussed and added support was given to the existing evidence that certain maternal blood group antibodies can affect embryos early in uterine life.

Abortion, Habitual↗
PubMedDate not supplied

Neonatal coxsackievirus group B infections: experience of a single department of neonatology.

Coxsackie infections in 14 infants born in a single neonatal unit were studied. The clinical presentation was mild nonspecific disease in eight infants and an overwhelming multiorgan disease in six. Three infants with systemic disease died. Vertical transmission of the virus from a colonized mother was documented in five mothers who infected seven infants. The remaining seven infants were infected horizontally, presumably from infected personnel. Coxsackie B1 was isolated in four of the cases and type B3 in two cases of systemic disease. Intravenous gammaglobulin combined with human leukocyte interferon was utilized in three cases of overwhelming disease and two infants of these infants survived.

Acyclovir↗
PubMedDate not supplied

Prevalence of HBsAg carriers in pregnant women in Jerusalem: risk for horizontal transmission to family members.

A prospective study was undertaken in Jerusalem to quantitate the HBsAg prevalence rate in pregnant women, to assess the effect of ethnic origin on HBsAg prevalence rates, and to determine the impact of HBsAg carrier state on hepatitis B virus horizontal transmission in the family. Of the 6,572 women screened at the time of delivery, 42 (0.64%) were found to be HBsAg positive. Although the percentage of Moslem women was 3.4% of the total study population, they accounted for 23.8% of the HBsAg positive mothers. This resulted in a prevalence rate of 4.48% as compared to only 0.5% in the Jewish population (P < 0.01). Nine percent of siblings born to HBsAg positive mothers and 29% of the husbands were found to be horizontally infected.

Carrier State↗
PubMedDate not supplied

Selected epidemiological features of herpes genitalis in Israel based on laboratory data.

The incidence in Israel of genital infection with herpes simplex virus (HSV) has been increasing steadily over the last two decades. During the years 1973-91, 1,508 patients had an HSV infection confirmed by viral culturing. The yearly incidence of new cases rose from sporadic cases in the seventies to 32.4 cases per 1,000 patients in 1990. The age distribution pattern did not change since 1980 and showed a peak incidence in subjects aged 20-40 years. The increase of HSV type 2 (HSV-2) infection rate in the Israeli population, as judged from specific geometric mean titers (GMT), rose from 15.25 in 1970 to 89.3 in 1991, while the GMT for HSV type 1 (HSV-1) did not increase significantly. The incidence of HSV-2 positive subjects (HSV-2/HSV-1 antibody ratio > or = 1) was low in the Jewish Israeli population, compared to other demographic areas. The predominant type of genital infection was HSV-2, although 21% of genital isolates were HSV-1.

Adolescent↗
PubMedDate not supplied

A seroprevalence study of herpes virus type 2 infection in Israeli women: implications for routine screening.

The aim of the study was to obtain data on the prevalence of herpes simplex virus type 2 (HSV-2) in selected populations of women and to identify groups that might benefit from routine prenatal screening. The prospective seroprevalence study was performed in 1,921 women in Israel during the period 1986-90. Four different population groups of women 17-60 years old were included. Groups 1 and 2 comprised 1,214 healthy female government employees and kibbutz and moshav residents, and Groups 3 and 4 comprised 707 Jewish and non-Jewish women with gynecological complaints. HSV-2 antibody in the sera were studied by the microneutralization method. In the healthy women (groups 1 and 2), the prevalence of antibodies to HSV-2 was 2-3%. Genital HSV-2 asymptomatic shedding was 1%. In the women with gynecological complaints (groups 3 and 4) the prevalence of antibodies to HSV-2 was 10% in Jewish and 16% in non-Jewish women. These data support the conclusion that there is no justification for routine prenatal HSV-2 screening in Israel in a healthy female population.

Adolescent↗
PubMedDate not supplied

The inter-relationship of herpes virus, papilloma 16/18 virus infection and Pap smear pathology in Israeli women.

A previous survey of the seroprevalence of the herpes virus type 2 (HSV-2) infection in Israel provided us with an opportunity to study a) the prevalence of human papillomavirus (HPV) 16/18 in selected groups of women; b) the correlation between the infection with HSV-2, HPV-16/18 and Papanicolaou (PAP) pathology; and c) to identify groups of women who might benefit from routine PAP screening. Four different population groups of women aged 17-60 years were studied: groups 1 and 2 comprised healthy women government employees and kibbutz and moshav residents, respectively, and groups 3 and 4 comprised Jewish and non-Jewish women with gynecological complaints. In women without gynecological problems the prevalence of HPV-16/18 was 1.8% in group 1 and 0% in group 2. The prevalence was several-fold higher in the Jewish and non-Jewish gynecological clinic groups, 9% and 12%, respectively. There was no correlation between the prevalence of HSV-2 antibodies and HPV-16/18 infection in women without gynecological problems. One of the 692 women studied had markers of both infections. The very few cases of cervical intraepithelial neoplasia (CIN) II and CIN III occurred in women who were negative for HSV-2 and HPV-16/18 infection. Thus from our limited study, it is not possible to define any group of healthy women who might benefit from continuous PAP smear screening for cervical cancer.

Adolescent↗