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Biomedical subjects

M Iio

Publications and source records attributed to M Iio.

At least 163 records · Page 9Linked to original sources
PubMed1985

Solitary renal hamartoma not associated with tuberous sclerosis: roles of CT and angiography.

CT and angiography of five solitary renal hamartomas not associated with tuberous sclerosis are reviewed. CT revealed fat in four hamartomas and was the more reliable in the differentiation from renal cancer. Bleeding from the tumour was detected in two cases and the extent of each haematoma was precisely determined by CT. Angiography showed specific findings in only one tumour. In a pararenal hamartoma, angiography was of value in clarifying the renal origin of the tumour. Though angiography may be of help when CT is inconclusive, we think it should not be relied upon as a major diagnostic tool and we utilise it mainly for preoperative mapping and embolisation. In one case CT did not detect fat and preoperative diagnosis was impossible. In one case with haematoma, detection of fat was difficult. We believe potential hamartomas with no detectable fat should be treated as malignancy until proved otherwise. There seems to be discrepancy between the vascularity of the hamartoma and the degree of contrast enhancement (CE) with a bolus injection method; hamartomas seem to show weaker CE than that expected for renal cancer of equal vascularity, a fact which may differentiate solitary hamartoma from cancer.

Adult↗
PubMed1985

[SOL-detectability of liver SPECT--analysis by SOL detection model].

The purpose of this study is to evaluate the clinical efficacy of liver SPECT (single photon emission computed tomography). Eleven hospitals which are in or near Tokyo are participating in this study. Planar liver images and SPECT images of 134 cases which were retrospectively confirmed for its final diagnosis were collected. At the first study, the planar images (PS) were read by 13 nuclear medicine physicians. The second, the image reading by the combination of the planar images and the SPECT images (PS + SPECT) were performed. The confidence level of diagnosis for SOL (space occupying lesion) obtained by the image reading of PS and PS + SPECT has been analyzed by using the SOL detection model. The SOL detectability of PS + SPECT was higher than that of PS only. However, these differences were not statistically significant.

Diagnosis, Differential↗
PubMed1985

Synthesis of N-methyl and N-11C-methyl spiperone by phase transfer catalysis in anhydrous solvent.

Spiperone, a butyrophenone neuroleptic drug, has been used in binding studies of dopamine receptors. Långström et al. developed N-11C-methyl spiperone, and, in cooperate with Wagner et al., made it possible to visualize the distribution of dopamine receptors in the human brain in vivo. In this paper, we independently developed another synthetic method of N-11C-methyl spiperone using the phase transfer catalyst in an anhydrous solvent. Separation of the product is feasible only by passing the reactant solution through a Millipore filter and injecting it onto high pressure liquid chromatography (HPLC). The time required for the synthesis and purification of N-11C-methyl spiperone from 11C-methyl iodide and spiperone was 20 min. Radiochemical yield exceeded 35% against 11C-methyl iodide without correcting decay of the radioactivity.

Anhydrides↗
PubMed1985

[SOL-detectability of liver SPECT--analysis of the structure of ROC-curve].

The purpose of this study is to evaluate the clinical efficacy of liver SPECT (single photon emission computed tomography). The two examinations were performed in 76 cases with SOL (space occupying lesion) and 58 normal cases. The results of the image reading by the planar image only (PS) and that of the image reading by the combination of PS and SPECT (PS + SPECT) were analyzed by ROC (receiver operating characteristic) analysis. The ROC curves showed that SPECT appears to reduce the number of results which were equivocal by the image reading of PS only. The detectability of SPECT for SOL in the left lobe of liver was less than that of PS without statistical significance. However, the performance of SPECT for SOL in the right lobe of liver was significantly better than that of PS.

Evaluation Studies as Topic↗
PubMed1985

[Radiotherapy of metastatic bone tumor with a synthetic calcitonin derivative (Elcatonin) with irradiation].

Twenty cases of metastatic bone tumors were treated with Elcatonin together with irradiation, achieving pain relief in 47.3% of cases, improved bone scintigrams in 16.7% of cases and radiographic improvement of invaded bone in 7.7% of cases. It has reported that calcitonin is effective for pain relief in 50% of cases but for the radiographic improvement of bone lesions in only 0-10%. The life quality of patients with bone metastases is controversial since treatment techniques for advanced oncological patients has progressed remarkably. The pain relief obtained with calcitonin contributes significantly to improving the quality of life for such patients when administered in combination with conventional treatment modes.

Adult↗
PubMed1985

Effectiveness of ECG-gated magnetic resonance imaging in diagnosing cardiovascular diseases.

Nuclear magnetic resonance imaging (MRI) is a noninvasive method which can discriminate between flowing blood and vascular walls, and is expected to contribute to the diagnosis of cardiovascular diseases. Since the data acquisition by conventional MRI is too long for precise cardiac imaging, the ECG-gated method is mandatory in evaluating cardiac function and producing cardiac images of high quality. To evaluate the effectiveness of ECG-gated MRI, left ventricular wall motion and ejection fraction by MRI were compared with those obtained by radionuclide technique. Two types of MR imagers were used: one with a resistive magnet (0.15 Tesla) for 12 patients, and the other with a superconductive magnet (0.35 Tesla) for eight patients. MRI imaged cardiac muscle and vascular walls without the need for any contrast media or radionuclides. The superconductive apparatus provided better quality images than did the resistive one. Comparing MRI with radionuclide technique regarding left ventricular wall motion, resistive and superconductive MRI data correlated satisfactorily with those of radionuclide technique, except in the inferior wall, which was better evaluated by radionuclide technique. Left ventricular ejection fraction obtained by MRI was moderately lower than those obtained by radionuclide technique, though the correlation was good [r = 0.84 (resistive unit) and r = 0.85 (superconductive unit)]. In addition to three-dimensional morphological information, ECG-gated MRI provides information nearly comparable to that of radionuclide technique in the evaluation of left ventricular function and wall motion. Therefore, we regard gated MRI as effective in evaluating various aspects of cardiovascular diseases.

Adult↗
PubMed1985

[Diagnosis of temporal lobe epilepsy by positron emission tomography].

Positron emission tomography (PET) was performed in 18 temporal lobe epileptics. About 20 mCi of 11C-glucose was perorally administered to the patients and 30 minutes later scanning was started when the transport of 11C-glucose from blood to the brain tissue reached equilibrium. At the level of 25 mm above orbitomeatal line, the slice image of the temporal lobe shows a relatively high metabolic oval ring involving the amygdala, hippocapal formation and the hippocampal gyrus medially and the T1, T2 and T3 neocortices laterally in normal subjects. The epileptic focus, when detected on PET images, was observed as a defect in this oval ring. In 15(83.3%) out of 18 cases, the location of epileptic focus was confirmed as a low metabolic defect. This diagnosis rate was higher than that of other focal epilepsy by PET study. The locations of foci were divided into three types: mesial (5 cases), lateral (4 cases) and combined (6 cases). The seizure symptoms of the patients were analyzed in terms of the correspondence to the focus types. The results showed that automatism and pseudoabsence had a close relation to the mesial and combined types and psychical, vertiginous or visual seizures correlated to the combined and lateral types. Visceral or motor seizures were induced equally by any focus types. These facts suggested that automatism and pseudoabsence were correlated with the mesial organs such as the amygdala and hippocampus and psychical, vertiginous or visual seizures had origin in lateral neocortices. Visceral or motor seizures were supposed to be the results of the spread from the temporal focus to the adjacent structures.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Cerebral blood flow and metabolism in multi-infarct dementia].

Cerebral blood flow and oxygen metabolism were studied in three aged normal volunteers and 10 patients with multi-infarct dementia (MID) by Positron Emission Tomography using O-15. The diagnosis of MID was done according to the Loeb's modified ischemic score and X-ray CT findings. The MID patients, whose X-ray CT showed localized low density areas in the subcortical white matter and basal ganglia and thalamus, were studied. No occlusion was observed at anterior cerebral artery and/or middle cerebral artery on cerebral angiography. All cases of MID were mild dementias. Regional CBF, rOEF and rCMRO2 were measured by the steady state technique described by Terry Jones et al. The values of rCBF in MID patients were significantly low compared with those of aged normal subjects in frontal, temporal, occipital, parietal cortices and thalamus. The values of CMRO2 in MID were significantly low in frontal, temporal, occipital cortices and thalamus compared with normal subjects'. The OEF was 0.46 in aged normal subjects, and 0.52 in MID patients. The MID patients in the early stage of dementia showed the increased oxygen extraction fraction, and this fact suggests that ischemia is a significant pathogenic mechanism in the production and progression of multi-infarct dementia. The decrease of CBF and CMRO2 in MID compared from normal subjects' were most remarkable in frontal cortex. The impairment of mental functions in MID should be caused by the decreased neuronal activities in frontal association cortex.

Aged↗