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Biomedical subjects

M Iio

Publications and source records attributed to M Iio.

At least 217 records · Page 12Linked to original sources
PubMed1982

Identification of estrogen-inducible growth factors (estromedins) for rat and human mammary tumor cells in culture.

The role of polypeptide growth factors (estromedins) as mediators of estrogen-responsive mammary tumor growth is studied in this report. Three possible new mechanisms were investigated that include endocrine, autocrine, and paracrine related growth factors. The first hypothesis being tested is whether estrogens interact with target tissues and cause the biosynthesis and secretion of polypeptide growth factors, which then act as mitogens for normal and neoplastic mammary tissues. Data presented suggest that this mechanism involves estrogen interaction with uterus, kidney, and pituitary gland causing production of growth factors, which then enter the general circulation and promote growth of distant target tissues. This is an endocrine type mechanism. Another type of estromedin control (autocrine control) may be exerted in an autostimulatory way in which the target tissue produces the polypeptide factors for its own growth in response to estrogen stimulation. A variation of the autocrine mechanism may be a paracrine mechanism in which some cells of an estrogen-responsive normal or neoplastic tissue produce growth factors that act on adjacent or neighboring cells. From the data available, all three possible types of growth factors could be functioning synergistically to yield the final result of continuous estrogen responsive tumor growth in vivo.

Animals↗
PubMed1982

CT features of calcification in abdominal neuroblastoma.

The plan radiographs and computed tomography (CT) scans of 12 children with abdominal neuroblastoma were reviewed to evaluate the incidence and shape of calcification in the tumor. Calcifications were detected in 7 cases by plain radiographs and in 10 by CT. Small dotted and thin ring calcifications were better shown by CT. Ring calcification does not appear to be as rare as has been reported. It is emphasized that all ring calcifications in the vicinity of adrenal glands are not benign.

Abdominal Neoplasms↗
PubMed1982

[Sensitivity and precision of the 13C-breath test].

Sensitivity and precision of the 13C-breath test were assessed by examining a couple of limiting factors caused by the sensitivity of the instrument used for 13CO2 analysis, endogenous fluctuation of 13CO2 abundance, and the residual CO2 in sample storing tubes, vacutainers, etc. For 13CO2 analysis, a mass spectrometer equipped with a dual inlet, a dual collector, and an automated pressure matching system, was used. 15 ml vacutainers were used for sample storage. Endogenous fluctuation of 13CO2 abundance, however, was measured by putting the breath samples directly into the evacuated CO2 purification system, instead of using vacutainers. Endogenous fluctuation (S.D. = 0.202%) was the most significant limiting factor, compared with instrumental limitation (0.085%), or with influence of the residual CO2 (0.136%). Consequently, the sensitivity of the 13C-breath test was figured out to be 0.52%. This sensitivity is about 1,000 times lower than that of 14C-breath test. The precision was linearly dependent on 13C increase from basal 13C observed after administration of 13C enriched compounds, delta 13C, and was determined to be expressed as 1.94 delta 13C.

Adult↗