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Biomedical subjects

M Ichikawa

Publications and source records attributed to M Ichikawa.

At least 415 records · Page 23Linked to original sources
PubMed1976

The application of caerulein to cholangiography.

Caerulein was applied to oral cholecystography and the opacity of the common bile duct was evaluated at intervals. To 127 subjects whose gallbladder had been visualized by cholecystography was administered caerulein by intramuscular route in a dose of 0.2 mug per kg of body weight. As a result: 1. The visualization of the common bile duct reached its maximum 15 minutes after administration of caerulein (52% of the subjects); in total, 62.2% of the subjects responded to this cholecystography. 2. The visualization by caerulein was superior to that by the yolk both in its rate and intensity. 3. The cholangiogram taken after administration of caerulein was preferably available for diagnosis of bile duct lesions. Caerulein used for a pretreatment of drip infusion cholangiography (DIC) remarkably improved the picture in 3 of the 10 subjects in whom DIC alone had failed to show the bile duct. Thus, the application of caerulein to cholangiography facilitated diagnosis of bile duct lesions.

Bile Ducts↗
PubMed1976

Change in the mixed function oxidase system of liver microsomes in rats treated with 3'-methyl-4-dimethylaminoazobenzene.

The mixed function oxidase systems of plasma membranes, the Golgi apparatus, and smooth and rough endoplasmic reticula of the livers of rats fed on a standard diet containing 0.06% (w/w) 3'-methyl-4-dimethylaminoazobenzene were investigated. The components and activities of the mixed function oxidase systems of the smooth endoplasmic reticulum and Golgi apparatus were especially reduced by the carcinogen. The activities for hydroxylation of anilines and demethylation of p-nitroanisole and the contents of cytochromes P-450 and b5 of the submicrosomal fractions of the rats decreased considerably more than the activities of NADH- and NADPH-ferricyanide reductases. More than 90% of the ferri-cytochrome P-450 content of the 3'-methyl-4-dimethylaminoazobenzene induced microsomes at 20 K was in the low spin form.

Administration, Oral↗
PubMed1975

The fine structure of the parotid gland of the Mongolian gerbil, Meriones meridianus.

The parotid gland of the Mongolian gerbil, Meriones meridianus, was examined by the electron microscopy. A peculiar feature of the serous acinar cells in that mature secretory granules have a bipartite substructure consisting of a centrally-located large dense homogeneous core and the peripheral rim of a less dense, fibrillo-granular matrix. The latter is histochemically revealed to be rich in acid mucosubstance while the former may be mainly composed of zymogenic materials because of its dense homogeneous texture. Such a heterogeneity of granule content is detectable in all the materials examined, regardless of fixation and staining methods and of animal age. Another characteristic feature of the gland is observable in the duct cells, which provide the basal hemidesmosomes attached with microfilaments and the network system of agranular cytoplasmic tubules, closely related to the basal plasma membrane. Functional significance of these structures is discussed.

Animals↗