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Biomedical subjects

M I Resnick

Publications and source records attributed to M I Resnick.

At least 253 records · Page 14Linked to original sources
PubMed1981

Cyclophosphamide versus cyclophosphamide, methotrexate, and 5-fluorouracil in advanced prostatic cancer: a randomized trial.

Thirty-two evaluable patients with metastatic carcinoma of the prostate were entered into a prospective randomized trial comparing cyclophosphamide (CYC) with a combination of cyclophosphamide, methotrexate, and fluorouracil (CMF). Progressive disease after endocrine manipulation was noted in 97% (31/32) of patients before entry. Stable disease (S) was observed in 9 of 17 patients treated with CYC. One partial response (PR) and seven stable responses occurred in the 15 CMF patients. Median duration of stable response was 4.5 months for CYC and 4.5 months on CMF. Median survival of patients with PR and S receiving CYC was 10.1 and for CMF 8.8 months. Patients with progressive disease survived a median 1.7 and 2.6 months with CYC and CMF, respectively. Toxicity was moderate, and no deaths were attributable to sepsis or bleeding. Almost all patients in this study had bone lesions as the dominant site of disease; this made objective assessment of response difficult. There was no significant improvement in response conferred by the combination regimen. Although patients with metastatic prostatic cancer may benefit from chemotherapy, impressive clinical responses are uncommon.

Aged↗
PubMed1981

Evaluation and management of infection stones.

In summary, all patients with infection stones should undergo a preoperative diagnostic evaluation in order to identify any underlying metabolic abnormalities. All organisms infecting the urinary tract should be identified and appropriate antibacterial therapy instituted 48 to 72 hours preoperatively. Surgery should be undertaken not only to remove all stones but to correct any anatomic abnormalities within the kidney in order to improve urinary drainage and to diminish urinary stasis and infection. Postoperatively, all recurrent urinary tract infections should be treated vigorously. Continual efforts should be made to maintain a sterile urinary tract. All identified metabolic abnormalities will require appropriate treatment.

Bacteria↗
PubMed1980

Evaluation of prostatic carcinoma: noninvasive and preoperative techniques.

Transrectal ultrasonography was performed in 345 patients with clinical benign prostatic hyperplasia who underwent simple prostatectomy. Four patients with negative ultrasonic scans were found to have stage A2 prostatic tumors. Of the 57 patients with positive scans, ten were found to have clinically unsuspected carcinoma; however, changes secondary to carcinoma could not reliably be differentiated from those resulting from chronic inflammation and calculi. Transrectal portable ultrasonography is useful for the staging of patients with prostatic cancer, and four of the ten patients with seemingly stage B disease were found to have seminal vesicle involvement. Tumor response to endocrine therapy can be objectively monitored, but tumor reactivation often goes undetected. Because the technique does not reliably differentiate carcinoma, chronic inflammation, and calculi, the use of transrectal ultrasonography in the screening of asymptomatic patients in an effort to detect early carcinoma appears to be of limited value.

Carcinoma↗
PubMed1980

Sonolucencies in fetal and infant abdomen: implications for management.

The increased use of prenatal and antenatal ultrasonography will detect predictably abnormalities of fetal and infant anatomy not assessed or suspected previously. Three cases are presented illustrating similar ultrasonographic findings with different diagnoses and prognoses, and comparisons are made with other cases reported in the literature. Caution should be used in interpreting sonolucencies in fetal and infant abdomen to be diagnostic of a particular defect since further studies are required to define properly the specific abnormality so that proper treatment can be instituted.

Abnormalities, Multiple↗
PubMed1980

Diagnosis of ectopic ureterocele using ultrasound.

Three children with ectopic ureteroceles were examined with ultrasound, excretory urography, and voiding cystography. In all cases the ultrasound studies outlined the ectopic ureterocele within the bladder.

Child, Preschool↗
PubMed1980

Transrectal ultrasonography in the evaluation of patients with prostatic carcinoma.

There were 53 patients with biopsy-proved prostatic carcinoma evaluated by the usual modalities, in addition to ultrasonography. Of this group 23 patients underwent radical prostatectomy and ultrasonography was helpful in assessing tumor involvement around the seminal vesicles. Tumor response to hormonal therapy was detectable readily with ultrasonic imaging but tumor reactivation was not apparent consistently.

Adenocarcinoma↗
PubMed1980

Bilateral staghorn calculi--patient evaluation and management.

A total of 44 patients (17 men and 27 women) with simultaneous bilateral staghorn calculi underwent anatrophic nephrolithotomy with caliceal reconstruction. Excluding patients with urinary tract infection alone all but 3 had identifiable metabolic abnormalities that required treatment postoperatively. Based on numbers of kidneys operated upon the stone recurrence rate was 8.8 per cent for men and 7.4 per cent for women. No patient has required an operation for recurrent stone disease.

Adult↗
PubMed1980

Urinary beta 2-microglobulin excretion and renal lithiasis.

We assessed beta 2-microglobulin excretion in 42 active calcium oxalate stone-formers, 16 active struvite stone-formers, 4 active uric acid stone-formers, 14 inactive stone-formers and 21 non-stone-forming controls. The average excretion value was within normal limits for all groups and no significant differences existed. These observations coupled with previous findings of increased low molecular weight urinary proteins in active calcium oxalate stone-formers suggest the existence of specific alterations in tubular function in this specific group.

Beta-Globulins↗
PubMed1980

Calcium-binding proteins and renal lithiasis.

The present study consists of measuring calcium-binding activity in urine obtained from 17 metabolically active noninfectious calcium oxalate stone formers, six inactive calcium oxalate stone formers, two active uric acid stone formers, one active cystine stone former, and seven nonstone-forming controls. Twenty-four hour specimens were obtained from each patient and were ultrafiltered, utilizing a series of membranes to concentrate all macromolecules of molecular weight less than 50,000 daltons. The concentrated specimen was separated by gel filtration chromatography, and each fraction was analyzed for calcium-binding activity utilizing the chelex resin binding assay. Total urinary calcium binding protein activity was significantly greater in the active calcium oxalate stone formers when compared with either inactive calcium oxalate stone formers (P less than 0.025) or nonstone-forming controls (P less than 0.05). The number of uric acid and cystine stone formers was too small to make meaningful comparisons. Urinary excretion of calcium binding appears to be related to stone activity and may be specific for calcium stone formers. Their influence on stone formation deserves further study.

Calcium↗