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Biomedical subjects

M I Resnick

Publications and source records attributed to M I Resnick.

At least 235 records · Page 13Linked to original sources
PubMed1984

A methodology for the characterization of urinary glycosaminoglycans.

This study presents a method for the isolation and identification of urinary glycosaminoglycans. Aliquots of 24-hour urine specimens are ultrafiltered through a Biogel filtration column to obtain the macromolecular fractions. These fractions are then subjected to electrophoretic, enzymatic and chemical analyses to obtain qualitative and quantitative information about the glycosaminoglycans contained. The methodology presented is intended to be used in subsequent studies where data can be analyzed and determinations can be made concerning the character of glycosaminoglycans in the urine of stone formers and non-stone formers.

Chondroitin Sulfates↗
PubMed1984

Transrectal ultrasonography.

Transrectal ultrasonography is useful in assessing prostatic size, locally staging patients with prostatic carcinoma, and monitoring tumor response to endocrine therapy. New instrumentation provides the ability to perform needle biopsies under ultrasound guidance and potentially may be useful in the placement of radioactive seeds for treatment of localized malignancies.

Biopsy, Needle↗
PubMed1984

Clinical staging of prostatic cancer: new modalities.

Carcinoma of the prostate gland is currently recognized as being the third leading cause of death by cancer in American men. As in other neoplastic disease processes, the institution of adequate treatment depends on the clinical stage of the disease. Radionuclide bone scans, pelvic lymphangiography, computed tomography, and prostatic ultrasonography are relatively new imaging modalities currently available to help improve the accuracy of the clinical staging process.

Adenocarcinoma↗
PubMed1984

Hormonal therapy in prostatic carcinoma.

A significant number of patients with newly diagnosed prostatic cancer will be found to have metastatic disease at time of presentation. Since the work of Huggins and Hodges in the early 1940s, endocrine manipulation and androgen deprivation have become the accepted methods of treating this group of patients. Approximately 70 per cent to 80 per cent of patients demonstrate positive clinical response. Many experience a decrease in the size of the primary tumor, a decrease in the levels of serum acid phosphatase, relief of bone pain, a decrease in bladder outlet obstruction, an increase in appetite, and a generalized improvement in their overall sense of well-being. Adequate hormonal therapy usually consists of estrogen administration of bilateral orchiectomy, but other modalities include administration of antiandrogens, progestational agents, androgen-synthesis inhibitors, and, recently, gonadotropin-releasing hormone analogues. This latter group may have increasing applications, particularly if the evidence indicating reduced side effects continues to be substantiated. The probability of producing a positive clinical response is increased when hormonal therapy is introduced at the time of diagnosis, at which point the tumor is still likely to be androgen dependent.

Adenocarcinoma↗
PubMed1984

Emphysematous cystitis.

Emphysematous cystitis is a rare clinical entity. The most commonly afflicted patients are immunocompromised and have urinary retention. Most patients appear to have diabetes mellitus. Treatments consist of establishing bladder drainage and administering broad spectrum antibiotics. Successful treatment is based on early diagnosis and prompt treatment.

Aged↗
PubMed1983

Value of chest computed tomography in genitourinary malignancies.

Fifty-one patients with genitourinary malignancies with normal chest x-ray films all had chest computerized tomography in an attempt to detect metastatic disease. One patient with a hypernephroma and another with a bladder carcinoma had metastatic nodules detected. One patient with a testicular tumor had a histologically confirmed benign nodule. Chest computerized tomography should be performed on patients with tumors that have a high likelihood of metastasizing to the lung.

Female↗
PubMed1983

Assessment of the antihypercholesterolemic drug, Probucol, in benign prostatic hyperplasia.

Seventy patients were administered either Probucol, an anti-cholesterol agent or a placebo in a double blind manner for a period of 1 year in an effort to assess the effectiveness of this agent in treating benign prostatic hyperplasia. Sensation of incomplete voiding and peak and mean voiding flow rates showed a trend which indicated a therapeutic effect, however, this effect was comparable for both placebo and the drug group. This is interpreted as indicating the effectiveness of standard urologic therapy, and double blind trials are therefore needed in assessing different agents for the medical management of benign prostatic hyperplasia.

Cholesterol↗
PubMed1983

NMR scanning of the pelvis: initial experience with a 0.3 T system.

Pelvic NMR scans were obtained on 29 patients using a 0.3 T superconducting magnet system. Pathologies studied included four bladder carcinomas, four prostatic carcinomas, four ovarian dermoid cysts, three ovarian cysts, three endometrial carcinomas, two endometriomas, and one each of serous cystadenoma of the ovary, benign prostatic hypertrophy, pelvic hematoma, and undifferentiated sarcoma. NMR is a very promising method for characterizing pelvic masses and in staging pelvic malignancies. It can show primary tumors of the prostate, bladder, and uterus and reveals tumor extension into pelvic fat. The pelvis is particularly well suited to NMR scanning because of the abundant natural contrast provided by pelvic fat and by urine in the bladder and gas in the bowel. There is also less motion blurring than in the upper abdomen and chest because there is relatively little respiratory motion of pelvic organs. Various pulse sequences were used in scanning the pelvis; their relative merits are discussed.

Female↗
PubMed1983

Biochemistry of the nonhuman primate prostate and seminal vesicles. I. Some chemical parameters.

Normative biochemical values for cranial prostate, caudal prostate, and seminal vesicles were obtained in four macaque species and in baboons, with a view to chemical comparison of the cranial lobe with the other two tissues. The cranial prostatic lobe and the seminal vesicles were both significantly different from the caudal prostate in prostatic acid phosphatase activity. However, citric acid and lactate dehydrogenase in the cranial lobe were comparable to concentrations in the caudal lobe and significantly different from the seminal vesicles. Dihydrotestosterone was higher in content than testosterone in all tissues of each species examined. The nonhuman primate cranial lobe seems to be a link between the seminal vesicles and the caudal prostate.

Acid Phosphatase↗
PubMed1983

Biochemistry of the nonhuman primate prostate and seminal vesicles. II. Molecular weights of soluble proteins.

The molecular weights of the soluble proteins from cranial and caudal prostate and seminal vesicle tissues of several species of nonhuman primates were separated by electrophoresis. The tissues of animals belonging to the genus Macaca were found to be similar and are compared to those of other species. The molecular weights of these proteins are discussed with regard to known concentrations of prostate and seminal vesicle proteins.

Animals↗
PubMed1983

Anatrophic nephrolithotomy.

Anatrophic nephrolithotomy is indicated when multiple branched or staghorn calculi associated with infundibular stenosis must be removed and when previous surgery for calculi has been performed and dissection of the renal sinus is difficult if not impossible. Preoperatively all efforts should be directed toward characterizing those factors, both infectious and metabolic, that are associated with the formation of calculi. Postoperatively it is imperative to monitor the patient for recurrent urinary tract infection.

Humans↗
PubMed1982

High resolution analysis of human prostatic fluid by two-dimensional electrophoresis.

High-resolution two-dimensional electrophoresis has been used to resolve the major protein components of human prostatic fluid. Samples taken from individuals ranging in age from 19 to 74 years show ten major proteins that are consistently present in the fluids examined. Seven major proteins appear to have age-dependent patterns of synthesis and accumulation in the prostatic fluid. A major protein in the human fluid has electrophoretic properties similar to the glycosylated component of the rat ventral prostate secretory protein known as prostatic binding protein, prostatein, or estramustine binding protein. The isoelectric point/molecular weight of the human protein is 6.0/17,000 compared with 5.6/13,000 for the rat protein. Protein patterns from benign prostatic hyperplasia cases were not dramatically different from the normal patterns.

Adult↗
PubMed1982

Magnesium excretion and calcium oxalate urolithiasis.

One hundred fifty-five recurrent noninfectious calcium oxalate stone formers were evaluated in an effort to assess the importance of magnesium excretion on calcium oxalate stone formation. All patients evaluated had normal urinary magnesium excretion, and any elevation of the calcium/magnesium ratio was related to the presence of hypercalciuria. The findings indicate that magnesium deficiency does not appear to be a significant cause of calcium oxalate urolithiasis. If magnesium supplement is of value in some patients, it is likely related to its inhibitory effect on calcium oxalate crystallization.

Adolescent↗