Respiratory depression in the sedated bronchitic patient rapid version of the CO2 response curve.
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Biomedical subjects
Publications and source records attributed to M I Gold.
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Performance of four Spirostat units in measuring forced expiratory volume, 1 sec (FEV1) and forced vital capacity (FVC) were examined against that of a Collins spirometer using 10 volunteers. One Spirostat was discarded because of gross inaccuracy. The other three were evaluated for accuracy, repeatability and comparability among Spirostats. For FEV1 it reads high over the low ranges and low over the upper ranges. For the FVC, it reads high for all values up to 5.0 liters where it becomes quite accurate. The repeatability was considered only fair, since one spirostat differed from the other two; the comparability was acceptable.
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For years, halothane has been the anesthetic agent of choice for patients with chronic obstructive pulmonary disease (COPD) and reversible airway disease (asthma). Enflurane was compared with halothane in 100 patients with COPD substantiated by spirometry and history. Intraoperative and postoperative complications in each relatively homogenous 50-patient group were assessed. Spirometry, blood gases, chest x-rays, incidence of complications involving secretions, coughing, wheezing, and cardiovascular problems were similar in both groups. Enflurane appears to be equivalent to halothane as an anesthetic in such patients.
During anesthesia, wheezing and difficult breathing are dangerous, requiring prompt therapy. The pressurized isoproterenol cartridge described in this report may be interposed conveniently in the anesthesia breathing system, is inexpensive, and provides accurate dosage. This device proved effective in treating bronchospasm and decreasing wheezing and secretions in 11 out of 12 cases. The mean (+/- SEM) peak airway pressure was 43 (+/- 2) torr before and 31 (+/- 2) torr after treatment; mean Paco2 was lowered from 60 (+/- 6) to 47 (+/- 4) torr; mean pH increased from 7.24 (+/- 0.03) to 7.33 (+/- 0.03), and mean percent increase in Pao2 was 32 (+/- 13.4). No cardiac arrhythmias, tachycardia, or rise in blood pressure were observed.
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