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Biomedical subjects

M I Freeman

Publications and source records attributed to M I Freeman.

At least 19 recordsLinked to original sources
PubMed1996

Irreversible bullous keratopathy after air bag trauma.

PURPOSE: We describe an unusual case of corneal decompensation following air bag trauma in a 38 year-old-female. METHODS: The patient was followed clinically for 5 months post-injury with persistent corneal edema that failed to resolve, necessitating corneal transplantation. Scanning electron microscopy (SEM) of the corneal button was performed. RESULTS: SEM revealed localized areas of complete endothelial destruction. Other areas of the endothelium had cell counts under 1,000 cells per square millimeter. CONCLUSIONS: This case corroborates animal studies demonstrating endothelial cell loss from direct air bag trauma and stresses the need to possibly redesign this safety device for maximum driver protection.

Adult↗
PubMed1996

A 3-year prospective study of the clinical performance of daily disposable contact lenses compared with frequent replacement and conventional daily wear contact lenses.

PURPOSE: To determine the clinical performance of daily disposable contact lens wear compared to conventional daily wear contact lenses and frequent replacement contact lenses. METHODS: This 3-year prospective study was conducted in 12 U.S. practices. Of 338 eligible subjects enrolled (126 conventional daily wear, 144 frequent replacement, and 68 daily disposable), 229 subjects disposable group were compared with the conventional daily wear group and two sub-groups of frequent replacement subjects: (a) those with replacement at 2-weak intervals and (b) those with replacement at 1 or 3 months. RESULTS: Comparing the daily disposable and conventional daily wear groups, the daily disposable subjects were more likely to be asymptomatic, reported fewer symptoms of redness, cloudy vision and grittiness/dirty sensation, reported better vision and overall satisfaction, and had fewer lens surface deposits, complications, tarsal abnormalities, and unscheduled visits, while conventional daily wear subjects reported better lens handling. Comparing the daily disposable and frequent replacement (1/3 months) groups, daily disposable subjects reported fewer symptoms of foreign body sensation, redness, cloudy vision and grittiness/dirty sensation, reported better subjective vision, comfort and overall satisfaction, and has fewer lens surface deposits, complications, and tarsal abnormalities, while frequent replacement (1/3 months) subjects reported fewer dryness symptoms and better lens handling. Comparing the daily disposable and frequent replacement (2-weeks) groups, daily disposable subjects reported better subjective vision and overall satisfaction and had fewer lens surface deposits and tarsal abnormalities, while frequent replacement (2-weeks) subjects reported fewer photophobia symptoms. CONCLUSIONS: The results indicate that daily disposable wear may be the most trouble-free way of wearing contact lenses.

Adult↗
PubMed1994

Multisite comparison of contact lens modalities. Daily disposable wear vs. conventional daily wear in successful contact lens wearers.

BACKGROUND: RESULTS are reported for the first year of one facet of an ongoing multisite clinical investigation. In this article, one subpopulations of subjects wearing soft contact lenses on a daily disposable wear schedule (DDW is compared to a second subpopulation wearing lenses on a conventional daily wear (CDW) basis. METHODS: All subjects recruited were successfully wearing lenses on a conventional daily wear basis at the time of enrollment. In addition to an initial visit, follow-up visits occurred at 1, 4, 12, 26 and 52 weeks. Areas of assessment included vision, comfort, ocular health, subject-reported symptoms, lens surface deposits and overall satisfaction. A total of 70 subjects were dispensed lenses on a daily disposable schedule and 125 subjects were dispensed lenses on a conventional daily wear schedule. RESULTS: Five DDW subjects and 15 CDW subjects discontinued before the 52-week follow-up visit. When the findings of the 52-week follow-up visit were compared, the DDW group performed significantly better than the CDW group in the following areas: Snellen visual acuity, subjective vision and comfort assessment, symptomatology, lens deposits and overall satisfaction. In addition, while performance levels tended to improve in the DDW group when the results from the 52-week follow-up visit were compared with the 1-week follow-up visit, they tended to decline in the CDW group over this period of time. Subjects wearing lenses on a daily disposable basis were significantly less likely to report for an unscheduled visit than subjects wearing lenses on a conventional wear basis, with the DDW subjects reporting with less serious ocular health problems. CONCLUSIONS: Patients who were wearing conventional reusable daily wear lenses and refit into lens wear on a daily disposable basis realized clinically significant advantages compared to a similar population of patients who were refit with lenses worn on a conventional daily wear basis.

Adolescent↗
PubMed1991

Patient selection.

Explore the source record for details and available documents.

Contact Lenses↗
PubMed1990

Is daily wear better than extended wear? A rational approach to extended wear.

The physiologic and anatomic effects of contact lens (CL) wear include both short- and long-term changes in the corneal epithelium stroma, and endothelium. Although these effects can arise in all lens wearers, they are of greatest concern in users of extended wear lenses, owing to their association with an increased incidence of sight-threatening complications. The complications attendant on extended wear may be patient related, lens related, or care related, but they are not inevitable. Patient-related complications can be minimized if clinicians pay close attention to patient selection, lens fitting, and follow-up. Complications related to lens wear and care can be minimized if patients (a) follow the proper lens wear regimen; (b) observe appropriate lens care routines; (c) follow the proper lens disposal regimen; (d) monitor the appearance, visual acuity, and well-being of their eyes; and (e) immediately report any irregularities or changes in ocular status to their doctor. To ensure that such rules are observed, practitioners must educate their patients as well as their staff in these matters. They must also instruct patients not to wear extended wear lenses longer than 7 days at a time and to allow for an overnight respite from lens wear after this period of use.

Contact Lenses, Extended-Wear↗
PubMed1988

Effect of changing medication regimens in glaucoma patients.

When glaucoma medication fails to adequately control intraocular pressure (IOP), a second medication is frequently added. Before adding a second drug to patients whose IOP was no longer controlled by 0.5% timolol, we tested the effect of switching to another beta blocker, levobunolol (0.5 or 1%). We also evaluated the effect of study participation on compliance in the control group continuing to receive 0.5% timolol. In each treatment group, the IOP of approximately 30-40% of the patients was successfully controlled for the 3-month study period. The remaining patients did not exhibit significant pressure reductions and were dropped from the study within 2 weeks. We concluded that (1) the results of 'switch' studies without a control group must be interpreted carefully, and (2) the initiation of a 'new regimen' with an equieffective beta blocker may be sufficient to increase compliance and thereby control IOP.

Aged↗
PubMed1979

A method for delivery of ocular medications.

Many patients have difficulty placing medications into their eyes. Using a pair of inexpensive plastic sunglasses, a patient designed a simple device for instillation of ocular drops.

Aged↗
PubMed1979

Management of complications associated with lathe-cut soft contact lenses.

At the present time, nine lathe-cut lenses are FDA approved and commercially available in the United States. Complications of lathe-cut soft contact lenses cover a wide spectrum of problems. Five significant complications of lathe-cut lenses and their prevention and therapeutic management are discussed.

Conjunctivitis↗
PubMed1979

Flunisolide in chronic bronchial asthma.

Sixteen steroid dependent and 13 steroid independent patients with bronchial asthma were treated for three months with flunisolide by aerosol. Asthma improved in these patients, other medication usage decreased and adverse side effects were minimal. A significant increase in morning plasma cortisol levels occurred in steroid dependent patients, whereas cortisol levels in steroid independent patients remained normal. An unexpected decline in response to metyrapone occurred in both groups of patients and suggests that this test is affected by flunisolide usage.

Adrenal Cortex Function Tests↗