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Biomedical subjects

M Horiuchi

Publications and source records attributed to M Horiuchi.

At least 253 records · Page 14Linked to original sources
PubMed1989

An autopsy case of so-called midline malignant reticulosis followed by extensive dissemination with immunohistochemical evidence for its T cell malignancy.

An autopsy case of malignant midline reticulosis (MMR) is reported. The patient, a 42-year-old Japanese male, died after a clinical course of 22 months. Autopsy revealed extensive infiltration of generalized organs by the tumor cells, suggesting that the disease was highly malignant in nature. Staining with monoclonal antibodies against T-cell surface antigens Leu 4 on frozen sections and UCHL1 on paraffin-embedded sections enabled us to examine the phenotype of the tumor cells with good morphological preservation and to verify the T cell nature of the tumor.

Adult↗
PubMed1989

Regulation of aldosterone receptor in rat kidney cytosol by atrial natriuretic factor.

We investigated the effect of atrial natriuretic factor (ANF) on aldosterone receptors in the kidney cytosol, because the binding of aldosterone to aldosterone receptors in the cytosol is considered a critical step of its action. Rat atriopeptin III was injected into male Sprague-Dawley rats (200-250 g) via the femoral vein while under pentobarbital anesthesia, and aldosterone receptors in the kidney cytosol were determined. The maximum binding capacity and dissociation constant were calculated by the Scatchard analysis. Maximum binding capacity of both types of aldosterone receptor (Type I, high affinity and low binding capacity and Type II, low affinity and high binding capacity) gradually decreased after ANF injection, reached the lowest level after 2 hours, and then slightly recovered. When more than 2.5 micrograms/kg of rat atriopeptin III was injected, the density of aldosterone receptors significantly decreased. Injection of 12.5 micrograms/kg of rat atriopeptin III decreased maximum binding capacity of Type I receptor from 42.3 +/- 2.4 (mean +/- SD, n = 6) to 22.8 +/- 3.2 femtomole/mg protein (n = 6) (p less than 0.01), and that of Type II receptor decreased from 388 +/- 46 to 285 +/- 30 fmol/mg protein (p less than 0.01). Dissociation constant of both types of receptors did not change significantly after ANF injection. Plasma aldosterone concentration showed no significant change after ANF injection, and a significant change was noted after ANF administration on aldosterone receptors in the experiments on adrenalectomized rats 7 days after operation. Furosemide had no significant effect on aldosterone receptors in both normal and adrenalectomized rats.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenalectomy↗
PubMed1989

[Development and application of an optical system to measure the movements of organs with soft tissue].

We proposed a new optical system to measure the movements of less accessible organs with soft tissue. The sensor unit is composed of a phototransistor and two LEDs. Two LEDs of light sources are driven by two phase signals with phase shift of 90 degrees. The distance between the sensor and the measuring object can be obtained as the function of the phase angle of reflex light signal detected by the phototransistor. The system can be easily constructed and provides simultaneous recordings of multiple points with the fast response in real time. The Relative precision is 0.5 mm and the resolution is 0.05 mm. Output characteristic of the system was less affected by the reflection factor of the object. We conducted to observe the tongue movements in speech production.

Humans↗
PubMed1989

[Prosthetic application of digital processing of speech signals].

The purpose of this study was to investigate the acoustic characteristics of the nine sounds, /sa/, /si/, /ka/, /ki/, /ci/, /hi/ and /ri/, which were reported affected by wearing complete denture, through the acoustic analysis of speech samples uttered by nine male subjects. Spectrum analysis was done within the frequency range of 0 to 10 KHz according to the auto-correlation method of liner predictive coding (LPC) analysis. Results 1. The consonant parts of /sa/, /si/, /ci/ and /hi/ wee characterized by the spectrum envelopes and their peak frequencies derived from the LPC analysis of order 5. 2. The consonant parts of /ka/ and /ki/ were characterized by their first spectrum peak frequencies derived from the LPC analysis of order 10. 3. The consonant part of /ri/ was characterized by the spectrum envelope derived from the LPC analysis of order 24, and the sound waveform. 4. The frequencies of the formants (F 1, F 2, F 3) of the following vowels /i/ were derived from the LPC analysis of order 24. They were influenced by individual variations and preceding consonants. 5. Each sound had its own characteristics in the duration of the consonant and of the closure interval and the time from the end of preceding vowel to the beginning of the following vowel.

Analog-Digital Conversion↗
PubMed1989

[Studies on influences of artificial palatal plates on pronunciation].

UNLABELLED: The purpose of this study was to investigate the influence of the alteration of palatal form on pronunciation. Three types of artificial palatal plates simulating the upper complete denture, which artificial posterior teeth position was more lingually than natural dentition, were made for each dentulous subject. Difficulty of articulatory movements and sound qualities were assessed when the subjects pronounced /sa/, /si/, /ka/, /ki/, /ci/, /hi/, and /ri/ with each plate. The distortional sounds judged by auditory psychological experiment were analysed by acoustic methods, and mandibular movements during pronunciation of them were measured. RESULTS: 1. /ki/ and /hi/ were affected remarkably when the posterior position was more lingually, and /ri/, /ci/ and /sa/ were also affected. 2. The acoustic characteristics of distortional sounds were estimated by peak trajectories, supectrum envelopes, peak frequencies and sound waveforms of consonant parts, formant frequencies and formant trajectories of following vowels, and segemental durations. 3. Mandibular movements did not influence directory on the acoustic characteristics of distortional sounds. It was thought that tongue and lips mainly influenced on those.

Denture Bases↗
PubMed1989

[Malignant tumors of the ethmoid sinuses--treatment and prognosis].

From 1981 to 1987, 15 cases of malignant tumors of the ethmoid sinuses were treated by radiotherapy, either with or without chemotherapy. Pathologically, these cases consisted of 7 squamous cells ca., 2 transitional cells ca., 3 anaplastic ca., 1 adenoid cystic ca., 1 malignant teratoma, and 1 rhabdomyosarcoma. The three-year survival in all cases 37%. Of eight patients determined to be in stages I and II, 4 patients had a localized relapse locally within 10 months after treatment and a distant metastases developed at a later time in 4 patients, whereas in 7 patients in stage III and IV, a distant metastases developed in 5 patients immediately after radiotherapy.

Adult↗
PubMed1988

A case of renal angiomyolipomas associated with multiple and various hamartomatous microlesions.

A case of 50-year-old woman who demonstrated large intrarenal and externally protruding angiomyolipomas (AMLomas), unusual intraglomerular lesions and multiple hamartomatous microlesions of various types within the kidney is reported. This type of intraglomerular lesion has been briefly described only twice previously in patients with tuberous sclerosis (TS), and is unique in its location and histological appearance. The lesions are mainly composed of proliferating mesangial cells and are hamartomatous in nature. Although no stigmata of TS other than renal AMLomas are apparent in this case, the presence of many renal hamartomatous lesions suggests the possibility of a forme fruste of TS.

Female↗
PubMed1988

Bronchial carcinoid tumor mimicking acinic cell tumor.

A rare case of carcinoid tumor mimicking an acinic cell tumor is presented. A bicameral tumor measuring 8 x 6 mm in size was recognized in the right lung (B5bi) upon gross examination. Microscopically, the tumor consisted of basophilic polygonal cells forming an acinar pattern. Ultrastructurally, the majority of tumor cells had large membrane-bound cytoplasmic granules, measuring about 600 nm in diameter, which were similar to secretary granules of serous acinar cells (zymogen granules). These findings suggested that the tumor might be an acinic cell tumor originating from the bronchial gland. However, tumor cells were shown to be negative for periodic and Schiff (PAS) stain or lactoferrin, lysozyme and amylase immunohistochemically. On the other hand, they were shown to be argyrophilic by Grimelius stain and showed immunohistochemically positive reaction for serotonin, suggesting that the granules were neurosecretory granules and not zymogen granules. Based on these findings, we concluded that this tumor was an unusual variant of carcinoid tumor mimicking acinic cell tumor. Although carcinoid tumor has a wide histological spectrum, there has been no reported case, to our knowledge, of acinic cell tumor-like carcinoid tumor.

Bronchial Neoplasms↗
PubMed1988

[Clinical study of combination chemotherapy using carboquone, cisplatin, UFT and OK-432 in 7 cases of advanced gastric cancers and a relapsed gastric cancer].

In 8 cases of advanced and/or relapsed gastric cancer (7 cases advanced, 1 case relapsed), we undertook combination chemotherapy with systemic administration of cisplatin and celiac arterial infusion of carboquone intermittently under continuous administration of OK-432 i.m. and UFT p.o. The male to female ratio was 5 to 3 and the age distribution from 53 to 77 years (mean age, 70 years.) Eight cases were divided into the following histological types: 1 papillary adenocarcinoma, 1 well-differentiated tubular adenocarcinoma, 3 moderately differentiated tubular adenocarcinomas, and 3 poorly differentiated adenocarcinomas. Complete response (CR) was obtained in one case, partial response (PR) in four cases, minor response (MR) in two cases, and no change (NC) in one case. The response rate was 62.5%. CR was noted in a relapsed case. The median survival time from the beginning of the chemotherapy was 8 months (ranging from 6 to 13 months). The major toxicity was bone marrow suppression, but there were no cases of serious renal damage.

Adenocarcinoma↗
PubMed1988

Application of lipid microsphere drug delivery system to steroidal ophthalmic preparation.

The applicability of a lipid microsphere drug delivery system to ophthalmic preparations was examined using a lipid microsphere containing hydrocortisone 17-butyrate 21-propionate (HBP). 3H-labelled HBP ophthalmic suspension and 3H-labelled HBP lipid microsphere were applied to rabbit eyes, and the eyes were enucleated after 1 and 3 hours to determine 3H-labelled HBP levels in the ocular tissues. The lipid microsphere proved to deliver the drug to the anterior ocular tissues more significantly than the ophthalmic suspension. It is suggested that the lipid microsphere ophthalmic preparation of various lipophilic drugs including steroids may be useful as one of the drug delivery systems for ophthalmic therapy.

Animals↗