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M Hirokawa

Publications and source records attributed to M Hirokawa.

At least 199 records · Page 11Linked to original sources
PubMed1988

[Two cases of urethral leiomyoma].

Two cases of urethral leiomyoma are reported. Two Japanese women 39 and 28 years old presented with the complaint of a painless mass protruding from the anterior wall of urethra to urethral meatus. The mass was firm with associated condyloma acuminatum on its surface and was easily removed by surgical excision. Sixty-four cases of urethral leiomyoma have been reported in Japan before the present cases. The majority of them were in females. The peak of incidence was in the 30th to 40th decade, suggesting the relationship of urethral leiomyoma to female sex hormones. No malignant development has been described. Judging from these findings, it appears possible to differentiate leiomyoma of urethra from caruncle, urethral prolapse or urethral carcinoma by careful inspection and palpation of a mobile firm mass under epithelium.

Adult↗
PubMed1987

[A case of inverted papilloma of the ureter with malignant findings].

A 70-year-old female with inverted papilloma of the ureter is presented. She was hospitalized because of asymptomatic macrohematuria. Excretory urography and retrograde pyelography demonstrated a filling defect with smooth contour at the mid-portion of the right ureter. Abdominal computer tomographic (CT) scan showed mass lesion (CT number 41) at the same portion as the filling defect. She was diagnosed as having an ureteral tumor and right nephroureterectomy was performed. The gross specimen contained a 24 X 12 mm, polypoid, pedunculated and smooth-surfaced tumor. Pathological diagnosis was inverted papilloma. However, microscopic examination revealed a malignant finding corresponding to transitional cell carcinoma grade 1. From the Japanese and foreign literature, 25 cases of ureteral inverted papilloma were collected and are reviewed. Clinical and pathological features are discussed.

Aged↗
PubMed1987

[Liposarcoma of the spermatic cord: a case report].

A case of spermatic cord liposarcoma is reported. A 66-year-old male visited our hospital with the complaint of right scrotal swelling. Laboratory and radiological examinations were unremarkable. A right high orchiectomy with en bloc resection of pericordal tissue was performed. Histological examination revealed well-differentiated liposarcoma of spermatic cord. There are 19 cases of spermatic cord liposarcoma reported in Japan.

Aged↗
PubMed1986

Occurrence of genital tract abnormalities and bladder hernia in female mice exposed neonatally to tamoxifen.

Three groups of female C57BL/Tw mice given 5 daily injections of 2, 20 or 100 micrograms tamoxifen (Tx) starting on the day of birth were killed at 35 and 150 days of age. About a half of the mice killed at 150 days had been ovariectomized at 90 days. Uterine hypoplasia, myometrial involution and suppression of the uterine-gland genesis were found in the 2 age-groups of Tx-treated mice. Vaginal hypoplasia and hypospadia were common abnormalities in 150-day-old Tx-treated mice. Vaginal adenosis was encountered in 35-day-old mice treated neonatally with 20 or 100 micrograms Tx, but not in 150-day-old group. Permanent proliferation of vaginal epithelium was not induced by Tx. More than 80% of oocytes in small follicles were degenerated in Tx-exposed mice at 150 days, but not so in those at 35 days. Ovaries of neonatally Tx-exposed mice lacking corpora lutea made no luteinizing response to human chorionic gonadotropin injected prepubertally. Urinary-bladder hernia with or without caecum hernia frequently occurred in 150-day-old mice given 20 or 100 micrograms Tx. The present study revealed that neonatally administered Tx causes various abnormalities in gonad and genito-urinary tract of female C57BL/Tw mice.

Animals↗
PubMed1986

Minimal change renal disease associated with thymoma and pancreatic carcinoma.

A case of minimal change renal disease associated with thymoma and pancreatic carcinoma is reported. A clinical manifestation of nephrotic syndrome developed about 5 weeks before the patient's demise and two different primary tumors were revealed only at the time of autopsy. Circumstantial evidences support that minimal change disease was a paraneoplastic process related to thymona rather than either the one related to pancreatic carcinoma or a mere coincidence. Review of the literature disclosed five cases of thymona with associated nephrotic syndrome. Herein, we report another case of such an unusual association and compare the present case with the previously reported.

Aged↗
PubMed1986

[Application of Testsimplets for classification of sperm morphology].

Testsimplets is a pre-stained, ready-to-use slides for differential blood cell counts. We have been using this Testsimplets slide to classify sperm morphology since 1978. Its characteristics is that it is very easy to prepare specimens quickly and we can see sperm morphology clearly for the classification of the sperm. We regard this Testsimplets slide as a supravital staining. The disadvantage is that we can not preserve specimens for more than 24 hrs. Extensive use of the Testsimplets slide is a useful method for the classification of sperm morphology in the infertility clinic.

Benzoxazines↗
PubMed1986

Topical application of potent glucocorticoids augments epidermal beta-adrenergic adenylate cyclase response in vivo.

The effects of topical application of glucocorticoids on the epidermal beta-adrenergic adenylate cyclase response were investigated. A significant increase in this receptor response was observed 24 h following topical application of potent glucocorticoid ointments (0.12% betamethasone-17-valerate, 0.05% clobetasol-17-propionate). The application of a relatively weak glucocorticoid, hydrocortisone-17-butyrate, revealed no augmentation effect. There was no significant difference in other adenylate cyclase responses (adenosine-, and histamine-) between control and glucocorticoid-treated epidermis. UVB irradiation is known to augment the beta-adrenergic response of epidermis. Comparison of the effects revealed that topical glucocorticoid treatment had less effect than UVB irradiation, and when the UVB irradiation was combined with glucocorticoid treatment, the beta-adrenergic augmentation effect was not enhanced. Cyclic AMP phosphodiesterase activities were not significantly altered by the glucocorticoid-, UVB-, or combined treatments. Our data indicate that epidermal beta-adrenergic adenylate cyclase response is affected by topical application of 'potent' glucocorticoids in vivo. Although the effect is weaker than that induced by UVB irradiation, we believe the system might be a useful tool for dissecting the glucocorticoidal potency of topical preparations using the epidermal keratinocyte response in vivo.

Adenylyl Cyclases↗
PubMed1986

[Splenic metastasis of hepatocellular carcinoma].

It is known that hepatocellular carcinoma (HCC) frequently metastasises to various organs, but metastasis to the spleen is quite rare. We experienced two cases of splenic metastasis of HCC revealed by ultrasonography (US) or computed tomography (CT) and confirmed by autopsy. We report the morphological characteristics of the US or CT findings in these two cases. The first patient was a 68-year-old woman who was admitted with the chief complaint of abdominal fullness. US revealed a hypoechoic lesion in the liver and spleen. She died of hepatic failure about a month later, and splenic metastasis of HCC was confirmed by autopsy. The second patient was a 61-year-old man who was admitted with the chief complaint of swelling a cervical lymph nodes. US showed a mosaic pattern of a mass lesion in the spleen. The patient died of hepatic failure about two weeks later, and metastasis of HCC to the spleen was confirmed by autopsy.

Aged↗
PubMed1985

Pig-skin epidermal calmodulin: effects of antagonists of calmodulin on DNA synthesis of pig-skin epidermis.

Although epidermal keratinocytes contain significant amounts of calmodulin, the exact role of calmodulin in epidermal biological activity remains to be determined. Pig-skin (epidermal) calmodulin was purified to homogeneity by DEAE/Sepharose- and phenothiazine-affinity-column chromatography. The characteristics of the purified calmodulin proved to be in good agreement with those of calmodulin obtained from other sources. Phenothiazines (trifluoperazine and chlorpromazine), mepacrine, propranolol, and colchicine inhibited the effect of the purified epidermal calmodulin on the calmodulin-deficient phosphodiesterase of bovine heart. These calmodulin antagonists all had inhibitory effects on the thymidine incorporation of pig-skin epidermal keratinocytes. These observations support the assumption that calmodulin might play an important role in epidermal keratinocyte proliferation.

Animals↗