[Reliability and scope of errors in the cytodiagnosis of tumors].
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Biomedical subjects
Publications and source records attributed to M Hilgarth.
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In a therapeutic comparative study two trial-groups (1 and 2) of 30 pregnant women each suffering from iron deficiency anemia of light degree received randomly selected a combination of ferrous succinate and multivitamins (Multibionta-Eisen) or a combination of ferrous sulfate and folic acid (preparations ES). By both medications the decrease of hemoglobin, red blood count and hematocrit could be stopped and a re-increase of these values was seen afterwards. There was no significant differences in response between Multibionta-Eisen and ES. A significant increase of Hb, RBC and Hc as compared prior to treatment was limited to group 2. Possible causes for the non-significant results of group 1 are discussed. The results of the study are demonstrating a certain superiority of preparation ME. This combination showed at least equal efficiency as preparation ES in spite of a smaller iron dosage and was well tolerated without exception. Subjective complaints may be better improved by Multibionta-Eisen.
By using single-cell-DNS-cytophotometry in 28 single cases and 11 follow-up studies it was possible to differentiate the doubtful cytological findings and the mild and moderate dysplasia concerning the expected biological behaviour (risk of degeneration). If there are histograms similar to those with normal or inflammatory altered squamous epithelium, which are classified as "behaviour like a facultative precancerous lesion", further clinical observation is necessary. Histograms which show aneuploidy and/or wide spread to the right side are classified as "behaviour like an obligatory precancerous lesion". In these cases a conization should be performed, even if the findings are cytomorphological Pap III or mild dysplasias.
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The development and efficiency of the cytological laboratory at the Freiburg University Hospital (Department of Obstetrics and Gynecology) are demonstrated. The number of examinations and detected cervical carcinomas are reported. The different groupes of cervical smears according to the Papanicolaou classification are discussed. High value is set on voluntary check-up (quality control) on all cytological laboratories efficiencies.
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