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Biomedical subjects

M Hartog

Publications and source records attributed to M Hartog.

At least 55 records · Page 3Linked to original sources
PubMed1986

Effects of cyproterone acetate and a long-acting LHRH analogue on serum lipoproteins in patients with carcinoma of the prostate.

Fasting serum lipoproteins were measured in 10 untreated patients with carcinoma of the prostate (Group I), 17 patients with non-malignant urological disorders (Group II), and 12 patients on cyproterone acetate (Group III) and 5 on a long-acting luteinizing hormone-releasing hormone (LHRH) analogue (Group IV) for at least 2 months for carcinoma of the prostate. Total high-density lipoprotein (HDL) cholesterol levels were significantly lower in patients in Group III than all the other groups. Very low-density lipoprotein (VLDL) triglyceride levels were significantly higher in patients in Group III than those in Groups II and IV. These results suggest a potentially adverse effect of cyproterone acetate, but not of the long-acting LHRH analogue, on serum lipids, which is likely to be of relevance only in younger patients.

Buserelin↗
PubMed1985

Demonstration of an abnormality of C apoprotein of very low density lipoprotein in patients with gout.

The very low density (VLDL) apolipoproteins of 12 male patients with gout have been studied by analytical isoelectric focusing. The relative percentage distribution of the C apolipoproteins was calculated and compared with that from 12 normolipidaemic and 12 'lipid-matched' controls. In the gout patients apolipoprotein CII (apo CII) represented 19.6% of the VLDL C proteins and the CII/CIII2 ratio was 0.57. In the normolipidaemic controls apo CII represented 28.8% and in the lipid-matched controls 33.1% of VLDL apo C, and the CII/CIII2 ratio approached one in each control group. These differences were significant. This suggests that a reduction in VLDL apo CII may predispose to the hypertriglyceridaemia that is commonly found in patients with gout.

Adult↗
PubMed1984

Persistent fetal haemoglobin and falsely high glycosylated haemoglobin levels.

Some of the routine methods of measuring glycosylated haemoglobin depend on its difference in charge from haemoglobin A and do not distinguish between glycosylated haemoglobin and fetal haemoglobin. Two insulin dependent diabetics showed persistent discrepancies between their capillary blood glucose values and their glycosylated haemoglobin values measured by agar gel electrophoresis: the blood values were normal but the glycosylated haemoglobin values were raised. In one patient increases in insulin dose in response to the glycosylated haemoglobin results repeatedly produced hypoglycaemia. Both patients were found to have higher than normal concentrations of fetal haemoglobin; and when measured by the thiobarbituric acid reaction their glycosylated haemoglobin levels were almost normal. This problem may be avoided by using a method that distinguishes between fetal and glycosylated haemoglobin or by testing glycosylation of hair or serum albumin if discrepancies arise. This is particularly important during pregnancy, when some women have an increase in fetal haemoglobin.

Adult↗
PubMed1984

Glycosylation of hair: possible measure of chronic hyperglycaemia.

To determine whether hair is excessively glycosylated in diabetes mellitus 4 cm hair samples were taken proximally from behind the ear in 50 white non-diabetics and 46 diabetics. Hair glycosylation was assayed by a modification of the thiobarbituric acid reaction. Blood was taken from the diabetics at the same time for measurement of glycosylated haemoglobin concentration. The mean (1 SD) concentration of fructosamine (mumol/100 mg hair) was 0.054 (0.011) for normal hair. Glycosylation was not related to sex, age, or hair colour. The diabetics' hair was more heavily glycosylated (0.097 (0.045] than normal (p less than 0.01) and there was a correlation between hair glycosylation and the concentration of glycosylated haemoglobin in the diabetics (r = 0.71; p less than 0.01). Hair from non-diabetics showed a stable time related increase in glycosylation when incubated with glucose. Glycosylation of hair might provide a stable long term measure of tissue glycosylation, useful in the investigation of microvascular complications of diabetes mellitus.

Adolescent↗
PubMed1984

Correlation between skin glycosylation and glycaemic control in human diabetes.

Glycosylation of human skin has been measured by an adaptation of the thiobarbituric acid reaction on samples obtained mainly at autopsy from normal and diabetic subjects. The mean (+/- 1 SD) glycosylation of skin from 33 normal subjects was 0.072 +/- 0.012 mumol fructosamine/100 mg wet weight tissue compared with 0.127 +/- 0.034 mumol (P less than 0.01) in the 10 diabetic subjects. There was a correlation between mean blood glucose levels in the 6 months before death and skin glycosylation in the diabetics, (r = 0.71, P = 0.025), but no correlation between age, sex, or the presence or absence of diabetic complications and skin glycosylation. Skin glycosylation in samples from four non diabetics was increased from 0.075 +/- 0.015 to 0.126 +/- 0.01 mumol fructosamine/100 mg wet weight tissue (P less than 0.01) after incubation with 50 mmol/l glucose solution for 7 d at 37 degrees C.

Adolescent↗
PubMed1984

Cushing's syndrome and bronchial carcinoid tumour.

Adrenal function test results in a girl with Cushing's syndrome and a bronchial carcinoid tumour suggested pituitary dependent hypercortisolism. Resolution after excision of the tumour indicated that her condition had been caused by ectopic adrenocorticotrophic hormone secretion. Conventional tests of adrenal function may be misleading in cases of adrenocorticotrophic hormone secreting bronchial carcinoid tumours.

Adolescent↗
PubMed1984

Is soft tissue radiology useful in acromegaly?

Twenty-six acromegalics had measurements of serum growth hormone (GH) levels during a glucose tolerance test, X rays of the heel for heel pad thickness, and of the hand for bone/soft tissue ratio. These measurements were performed before and between 2 and 7 years after treatment, which was by transethmoidal hypophysectomy, external irradiation or a combination of the two. Neither the heel pad thickness nor bone/soft tissue ratio correlated with the mean serum GH nor with each other before and after treatment. The nine patients who were assessed as showing a good clinical response to treatment showed a significantly greater fall in mean serum GH than the 17 patients who were assessed as unchanged or partial responders (40.1 +/- 20 mmu/l compared with 9.9 +/- 14.0 mmu/l, p = 0.02). However, there were no significant differences in changes of heel pad thickness nor bone/soft tissue ratio between these groups. It is concluded that these radiological measurements of soft tissues are unhelpful in the follow-up of acromegalic patients.

Acromegaly↗
PubMed1984

Improved diabetic control in insulin-dependent diabetics treated with insulin and glibenclamide.

A randomized double blind trial of insulin and glibenclamide treatment vs insulin and placebo was carried out in 20 insulin-dependent diabetics. Nine patients were C-peptide secretors and all increased their C-peptide output during a 50 g OGTT at the end of the insulin and glibenclamide treatment period by a mean of 47%. At the same time their mean daily blood glucose fell from 8.4 +/- 1.7 to 7.4 +/- 1.5 mmol/l and their HbA1 from 8.1 +/- 0.5 to 7.5 +/- 0.9% (mean +/- SD). There was no change in any of the measurements of diabetic control in C-peptide non-secretors and no evidence for any extra-pancreatic effects of glibenclamide in this group of patients. Combined insulin and glibenclamide treatment may produce a useful improvement of diabetic control in insulin-dependent diabetics who still secrete some endogenous insulin, although further studies are required.

Adult↗
PubMed1983

Not just fibre--the nutritional consequences of refined carbohydrate foods.

The dietary intake of 28 volunteers was assessed over two 6-week periods while they ate, alternately, a diet containing refined carbohydrate foods in commonly consumed amounts and a diet virtually devoid of such foods. The following nutritional effects of refined foods were observed: increased energy intake (except in low consumers of sugar), decreased intake of dietary fibre, and decreased intake of nearly all the vitamins and minerals recorded in tables of food composition. These effects may have harmful consequences.

Adult↗
PubMed1983

The effect of bromhexine on experimentally induced diabetic nephropathy.

Diabetes was induced in male Wistar rats by a single i.v. injection of streptozotocin (40 mg/kg). Animals were treated with bromhexine at 2 dose levels (2.5 mg/kg/day and 25 mg/kg/day) for 13 months thereafter and compared to non-diabetic controls and untreated diabetic animals. Renal pathology showed a significant increase in glomerular volume and basement membrane thickening in untreated diabetic animals. The higher dose bromhexine treated diabetic animals showed a significant decrease in glomerular volume as compared with diabetic animals not given bromhexine.

Animals↗
PubMed1982

Doves in false garb.

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International Cooperation↗
PubMed1982

Assessment of the metabolic effects of dietary carbohydrate and fibre by measuring urinary excretion of C-peptide.

An assessment of the metabolic effect of dietary carbohydrate on daily insulin secretion, reflected by the 24-h urine output of C-peptide, has been made. Urinary C-peptide excretion increased when the carbohydrate intake of 6 normal subjects was increased from 200 to 400 g. A high-fibre diet rich in beans and lentils caused a significant fall in urine C-peptide and a lowering of blood glucose values in both normal and diabetic subjects. This confirms the insulin-sparing effect of leguminous foods. An increase of dietary fibre to 50 g mainly as cereal fibre did not significantly alter urine C-peptide excretion in normal subjects. Urinary C-peptide estimations could be useful for assessing the effect of different diets on daily insulin secretion.

Adult↗
PubMed1982

The accuracy of drawing up insulin by insulin treated diabetics.

The accuracy of drawing up insulin was tested in a group of randomly selected insulin requiring diabetics. The mean error between patients of drawing up rapid acting insulin was + 5.6%, of intermediate acting insulin, + 4.9% and of a mixture of rapid and intermediate acting insulin, + 1.8%. There was no correlation in percentage error in drawing up insulin the age of patient, duration of diabetes, dosage of insulin nor quality of diabetic control.

Adolescent↗
PubMed1981

Unrefined carbohydrate and dietary fibre in treatment of diabetes mellitus.

Sixteen diabetics were studied over six-week periods on two diets--a conventional carbohydrate-restricted diet and a diet which excluded all refined (fibre-depleted) carbohydrate but which allowed unrefined (fibre-intact) carbohydrate freely. On the latter, there was a substantial increase in dietary fibre intake. Despite this, there was no change in 24-h urinary excretion of glucose nor in blood glycosylated haemoglobin concentration, and there was only a modest improvement in post-prandial plasma glucose concentration. We suggest that simply switching from refined to unrefined cereal foods without increasing total carbohydrate intake is unlikely to produce much improvement in diabetic control.

Adult↗