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Biomedical subjects

M Haraguchi

Publications and source records attributed to M Haraguchi.

At least 163 records · Page 9Linked to original sources
PubMed1987

Growth mode and DNA ploidy in mucosal carcinomas of the stomach.

Modes of cancer growth and DNA ploidy were studied in 66 patients with mucosal carcinoma of the stomach. The modes of growth were classified into five histologic patterns; elongated tubular (three patients), expansive (18 patients), tubular and solid (14 patients), carcinoma in situ (10 patients) and infiltrative (21 patients). In every patient, all or most lesions with elongated tubular, expansive, and carcinoma in situ growths were located in the pyloric gland area of the stomach, and were less than 4 cm in diameter. Histologically, the adenocarcinomas papillary or well-, or moderately differentiated. Most lesions with an infiltrative growth were located in the intermediate pyloric and fundic glands areas, depressed in gross appearance, and composed of poorly differentiated glandular or signet ring tumor cells. The lesions with a tubular and solid growth were present in the pyloric gland or intermediate area, and were classified as well-, moderately, or poorly differentiated adenocarcinoma. All lesions with an elongated tubular, tubular and solid, and carcinoma in situ growths, and most lesions with an infiltrative growth showed a narrowly restricted DNA distribution (Type I or II), while most lesions with an expansive growth had mostly a widely scattered DNA distribution (Type III), representing a higher malignant potential.

Adult↗
PubMed1987

Heterogeneity of DNA ploidy in patients with undifferentiated carcinomas of the stomach.

DNA ploidy was determined by cytophotometric DNA analysis in 20 patients with undifferentiated carcinomas of the stomach with serosal invasion. Measurements of DNA content were performed in 100 cells each in intramucosal, submucosal, muscular, and subserosal parts of a tumor. According to dispersion on the DNA histogram, DNA ploidy patterns were divided into low and high ploidy groups. Fourteen tumors (70%) showed the same ploidy in every layer (homogeneous DNA ploidy), 13 (65%) were low ploidy and, 1 (5%) was high ploidy. Heterogeneity of DNA ploidy was observed in the remaining six tumors (30%), which showed low ploidy in the mucosa, but high ploidy was observed in one or two deeper layers. In the six with heterogeneous DNA ploidy, there was more frequent metastasis to the lymph nodes (100%) and to the peritoneum (67%) than those with homogeneous DNA ploidy (50% and 21%, respectively). Cytophotometric DNA analysis of cells of undifferentiated gastric tumors suggested that there may be behavioral changes, depending on the degree of penetration into the gastric wall.

Carcinoma↗
PubMed1987

Accurate prognostic value of morphovolumetric analysis of advanced carcinoma of the stomach.

Two hundred and seventy-five patients with advanced carcinoma of the stomach invading the serosa were morphovolumetrically classified into three types: funnel, column and mountain. The funnel type, in which cancer cells narrowly invaded the deep wall compared with the extent of spread in the mucosa, was associated with less frequent metastases and a better prognosis (five year survival rate of 49 per cent). The column type, in which cancer cells invaded the deep wall as wide as the mucosa, and the mountain type, in which cancer cells widely invaded the deep wall, were associated with high frequent metastases and a poor prognosis (five year survival rates of 17 and 13 per cent, respectively). Division was also made into expanding and infiltrative types. In patients with the column type, those with infiltrative type had a poorer outcome than did those with the expanding type, while patients with the funnel type had a better prognosis than those with the other two types, regardless of the infiltration and expansion. The expanding type had a propensity for metastases to the liver and infiltrative type for peritoneal seeding. Combination of these classifications provides a prognostic evaluation and assessment of the behavior of advanced carcinoma of the stomach.

Adult↗
PubMed1987

Adenocarcinoma in the upper third part of the stomach.

Two hundred and twenty-three patients who underwent gastrectomy for adenocarcinoma arising from the cardia and upper third part of the stomach were studied with regard to esophageal invasion. One hundred and twenty-seven (57 per cent) had a malignant invasion into the esophagus and 96 (43 per cent) did not. In the curative instances, 52 of 74 patients (70.3 per cent) without esophageal invasion survived for five years, while 14 of 52 patients (26.9 per cent) with esophageal invasion survived: The prognosis of patients with esophageal invasion was poor regardless of the presence or absence of metastases to the lymph nodes. No patient who underwent noncurative resection survived for five years. To elucidate the high risk factors of esophageal invasion, a proportion of patients with esophageal invasion was statistically compared with patients without esophageal invasion, according to clinicopathologic factors. High risk factors included anatomic location, advanced disease and Borrmann IV type in gross appearance, more than 5 centimeters in diameter, positive serosal in filtration and positive metastases to the lymph nodes. Histologic type and mode of invasion did not relate to the esophageal invasion. The patients with high risk factors had a significantly poorer prognosis than did those without high risk factors. The results of the present study clearly show that high risk factors for esophageal invasion have an untoward effect on the rate of curative resection and the prognosis after removal of a lesion from the upper third part of the stomach.

Adenocarcinoma↗
PubMed1987

[A case of carcinoma in the lower abdomen treated successfully with oral administration of bestrabucil].

A 72-year-old female was admitted because of a palpable hard tumor, 15 X 7 cm in size, in the left lower quadrant of the abdomen. According to a diagnosis of retroperitoneal tumor, laparotomy was performed, revealing a large tumor extending between the descending colon and the pelvic cavity, which could not be separated from the retroperitoneum, uterus, left ovary, urinary bladder or rectum. A number of metastatic nodules were disseminated to the peritoneum and mesenterium. The pathological diagnosis of the nodules was poorly differentiated carcinoma of transitional cell type, origin unknown. After discharge, oral administration of bestrabucil (100-200 mg/day), the benzoate of an estradiol-chlorambucil conjugate, was given to the patient at an outpatient clinic. The tumor ceased to be palpable when the total amount administered reached at 14 g. Ultrasonography and computed tomography demonstrated significant reduction in tumor size. A decrease in the peripheral leukocyte count was observed after every consecutive administration and it took about 2 months to recover to the normal level. No other side effects were observed in this case. Although administration was stopped at a total amount of 16.1 g, reenlargement of the tumor has not been observed for 9 months.

Aged↗
PubMed1986

Clinicopathological features of mucosal carcinoma of the stomach with lymph node metastasis in eleven patients.

Of 568 patients with mucosal carcinoma of the stomach, only 11 (1.9 per cent) had a lymph node metastasis. The clinicopathological findings in these 11 patients are reviewed. Diameters of the lesions were over 2.0 cm. Seven were located in the body of the stomach and four in the antrum. Nine showed depressed lesions comprised of poorly differentiated adenocarcinoma and two were classed as elevated lesions consisting of well and moderately differentiated adenocarcinomas. There were six with accompanying peptic ulcers, all of which revealed depressed lesions with poorly differentiated adenocarcinoma. Metastases to proximal perigastric lymph nodes were found in eight while there were three with involvement of distant lymph nodes. All patients were surgically treated and all are doing well except for one who died of hepatic failure one month after operation. We recommend that the standard operation with lymph node dissection is essential, even in cases of mucosal carcinoma.

Adenocarcinoma↗
PubMed1986

Consistency of DNA ploidy between primary and recurrent gastric carcinomas.

Eleven patients with gastric carcinoma, who had undergone re-resection of the lesion due to recurrence in the remnant stomach, were the subjects of a cytophotometric DNA analytical study. The objective was to determine whether or not the DNA cytogenic profile of cancer cells would be consistent during the growth of the carcinoma. The DNA distribution patterns were grouped into types I, II, and III, according to the proportion of aneuploid cell population. Ten of 11 had the same DNA distribution patterns in the primary and recurrent lesions, while in the other one patient with type III in the primary lesion, type II was evident at the time of recurrence. The DNA cytogenic profile of cancer cells is thus a valid cell marker of a given tumor and should be applicable for determining the natural history of gastric carcinoma.

Adult↗
PubMed1986

[Cytophotometric DNA analysis of gastric carcinoma--relationship between DNA ploidy and lymph node metastasis].

Two hundred forty-four cases of gastric carcinoma were subjected to cytophotometric DNA analysis. DNA distribution patterns were roughly classified into low and high ploidies. The ratio of high ploidy was 55.7% (44/79) in the positive group of lymph node metastasis, which was significantly higher than 31.5% (52/165) in the negative group (P less than 0.01). The incidence of lymph node metastasis increased rapidly in the high ploidy cases with the progression of carcinoma, while it increased slowly in the low ploidy cases. DNA ploidy was well correlated with lymph node metastasis, and the mode of metastasis seemed to be different between the low and high ploidy groups.

Cytophotometry↗
PubMed1985

[The inhibitory effect of peptic ulceration on the growth of early gastric cancer].

The correlation between the growth pattern and peptic ulceration occurring in the cancer lesion was studied in early gastric cancer. Although the superficially spreading type (Super), which grows slowly, showed a high rate of being accompanied by peptic ulceration (74.0%), the deeply penetrating type (Pen), with rapid growth, had a lower such rate (Pen A- expansive type 9.7%; Pen B- infiltrative type 16.1%). Deep ulceration accompanied 32% of the Super cases, 12% of the small mucosal cases and no cases of the Pen type. The Super and small mucosal types located at the intermediate gland area had peptic ulceration more frequently than those at the other areas. The rate of the cases of peptic ulceration of undifferentiated adenocarcinoma was high in the Super and small mucosal types, and that of differentiated adenocarcinoma was 64.0% in the Super and only 33.3% in the small mucosal type. This study clarified that the growth of early gastric cancer was inhibitively influenced by peptic ulceration, which was modified by the localization and histologic type of the carcinoma.

Adenocarcinoma↗