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Biomedical subjects

M Hanssens

Publications and source records attributed to M Hanssens.

At least 55 records · Page 3Linked to original sources
PubMed1992

Congenital Marfan syndrome with contractures. A clinicopathological report.

Children with CMC present with blue sclerae, megalocornea, hypoplastic and translucent irides, miosis and high myopia. The lenses may be dislocated as in familial Marfan syndrome but they are often in place and microspherophakic. The clinical history of a boy with CMC is presented. Pathological examination of the eyes showed megalophthalmos with thinned sclera, anomalies of the chamber angle and iris, ill-developed ciliary body and choroid and a small in situ lens.

Adolescent↗
PubMed1991

Angiotensin II levels in hypertensive and normotensive pregnancies.

We measured circulating angiotension II by radioimmunoassay in women with pregnancy-induced hypertension (n = 54), and compared these values with those obtained in women with normal pregnancy (n = 18) and in non pregnant women (n = 20). Pregnant women had statistically significantly higher plasma angiotensin II [mean (SD): 41.3 (12.6) pg/ml] than non-pregnant women [29.2 (11.3) pg/ml; P less than 0.004]. Angiotensin II concentrations in women with pregnancy-induced hypertension [mean (SD): 31.7 (16.2) pg/ml] were, on average, 25% lower than in normal pregnancy (P less than 0.003) and resembled those obtained in non-pregnant women. The lowest angiotensin II levels were found in women with more severe forms of pregnancy-induced hypertension, such as proteinuric or superimposed pregnancy-induced hypertension. Review of the published studies on angiotensin II and our data suggest that the conflict among studies on angiotensin II levels in pregnancy-induced hypertension is largely due to the heterogeneity of the study populations in the various reports.

Angiotensin II↗
PubMed1991

Measurement of individual plasma angiotensins in normal pregnancy and pregnancy-induced hypertension.

Individual angiotensin peptides were measured by a high pressure liquid chromatography-RIA (HPLC-RIA) technique in the plasma of 20 nonpregnant women, 17 women with normal pregnancy, and 49 with pregnancy-induced hypertension. Immunoreactive angiotensin-II (ANG-II) consisted mainly of ANG-(1-8) octapeptide (greater than 65%), variable proportions (15-25%) of ANG-(4-8) pentapeptide, and small to negligible proportions of ANG-(2-8) heptapeptide and ANG-(3-8) hexapeptide. Levels of ANG-(1-8) were significantly higher in women with normal pregnancy than in both nonpregnant women (P less than 0.0006) and women with pregnancy-induced hypertension (P less than 0.008); in the latter, levels were lower with increasing severity of disease. Levels of ANG-(4-8) were higher in women with normal pregnancy than in women with pregnancy-induced hypertension or nonpregnant women. When expressed as a proportion of ANG-(1-8) levels, however, ANG-(4-8) levels were not higher in normal pregnancy than in women with pregnancy-induced hypertension or nonpregnant women. It is concluded that the well known increase in ANG-II levels in normal pregnancy relates predominantly to the active ANG-(1-8) octapeptide and to a far lesser extent to the smaller ANG peptides. Similarly, lower ANG-II levels in pregnancy-induced hypertension relate predominantly to lower ANG-(1-8) levels.

Adult↗
PubMed1991

Fetal and neonatal effects of treatment with angiotensin-converting enzyme inhibitors in pregnancy.

We conducted a systematic search of the world literature up to January 1, 1990 on the use of angiotensin-converting enzyme inhibitors for treatment of hypertension during pregnancy. A total of 25 publications reported 85 pregnancies in 81 women, including three twin pregnancies. Captopril had been used in 49, enalapril in 35, and both drugs in one of these pregnancies. The number of unbiased data are too limited to permit firm conclusions on teratogenicity, if any, of these agents. Contrary to earlier suggestions, we found no evidence that the use of these agents increases the likelihood of low weight for gestational age, respiratory distress syndrome, and/or persistent ductus arteriosus. Use of these agents in pregnancy can cause severe disturbance of fetal and neonatal renal function, such as oligohydramnios, pulmonary hypoplasia, and long-lasting neonatal anuria. Although the true incidence of these perinatal problems cannot be derived from the type of data hitherto available, there are strong suggestions that renal dysfunction is more common with the use of enalapril than with captopril. The frequency of serious perinatal complications is high enough to warrant extreme reluctance in prescribing angiotensin-converting enzyme inhibitors during pregnancy.

Abnormalities, Drug-Induced↗
PubMed1990

Endometriosis of the cecum and appendix: two case reports.

Two cases of endometriosis of the cecal area are reported. In one case, the endometriosis was located in the appendix causing intussusception into the cecum. Both cases were associated with localizations of endometriosis in the rectosigmoid.

Adult↗
PubMed1990

Activation of the renin-angiotensin system during ritodrine treatment in preterm labor.

Plasma renin activity, active renin concentrations, and total renin concentrations were measured serially in 15 women in preterm labor treated with ritodrine. All three parameters showed rapid increases during treatment that depended on ritodrine doses and paralleled changes in maternal pulse rate. The slope of the correlation between plasma renin activity and active renin concentrations suggested an increase in both active renin and renin substrate during ritodrine treatment. In contrast, levels of inactive renin remained unchanged for several hours during ritodrine infusion, showing only a late and much smaller response than that of either total or active renin concentrations. Thus ritodrine treatment results in further activation of an already activated renin-angiotensin system in pregnancy. This activation relates to an increase in both renin enzyme and its substrate. It may be responsible for the disturbance in water balance and the risk of pulmonary edema associated with beta-sympathomimetic drug treatment in preterm labor.

Female↗
PubMed1990

Malignant melanomas of the choroid and ruthenium applicators.

Fourty patients with a malignant melanoma of the choroid were treated with ruthenium applicators. Depending on the height of the tumour, the patients were divided into 3 groups. In the first group with a tumour height superior to 6 mm the results were poor as well from a functional point of view as considering tumour regression. In a second group with a tumour height between 5 and 6 mm the results were favourable concerning tumour regression, but only in 50% of the cases did the eye remain functional. The results in the third group with a tumour height between 2 and 5 mm were satisfactory. Tumour regression was obtained in 96% of the eyes; 86% of the eyes remained functional. Tumour related death (7.5%) was not correlated with initial height of the tumour at the time of diagnosis.

Adult↗
PubMed1988

Primary cardiac tumors: retrospective evaluation of 15 consecutive patients.

During a decade (1975-1985) 15 patients have been treated for a primary cardiac tumor at the University Hospital of Ghent. Histological examination revealed both benign (n = 12) (myxoma, pseudomyxoma, myxoid degeneration) and malignant (n = 3) (angiosarcoma) tumors. Tumor diagnosis generally was made by echocardiographic and/or angiocardiographic examination of patients presenting with various constitutional and/or cardiac symptoms. In two patients however diagnosis became obvious by histological examination of the material removed during acute embolectomy. All tumors were surgically resected with the aid of extracorporeal circulation. Benign tumors have generally good prognoses, although rhythm or conduction disturbances, complete obstruction or embolization can entertain malignant consequences. Three of our patients died of such a complication. Therefore all cardiac tumors should be resected as soon as possible after diagnosis. One patient showed evidence of recurrence of the tumor. Malignant heart tumors have bad prognoses: all three of our patients died within two years.

Adult↗
PubMed1985

Acanthamoeba keratitis. A clinicopathological case report.

A case of amoebic keratitis is described in a 34-year-old male patient who got glass wool dust in his eye. The keratitis ran a chronic course over more than 8 months and was resistant to topical antibiotics, steroids and antiviral drugs. A perforating keratoplasty was performed, and 1 year later the condition appears satisfactory. Histopathological examination of the corneal disc revealed many encysted amoebae which were classified as belonging to the genus Acanthamoeba. This is the first case of amoebic keratitis to be recorded in Belgium. The report includes a review of the literature on the subject.

Adult↗