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Biomedical subjects

M Hamza

Publications and source records attributed to M Hamza.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Suppressive T cell function of Epstein-Barr virus induced B cell activation in active Behçet's disease.

B and T cell function were studied in 10 patients with active Behçet's disease (BD) and in 10 normal subjects. Peripheral B lymphocytes infected with Epstein-Barr virus (EBV) were cultured for 20 days in the presence or absence of autologous T cells. Immunoglobulin M and G secretions into the supernatants were assessed with an enzyme-linked immunosorbent assay. The extent of suppression of EBV-induced B cell activation by autologous T cells was significantly decreased in active BD patients as compared to normal subjects at a T:B ratio of 1:1, whereas the suppression ratio was in the normal range at a T:B ratio of 4:1. The IgM and IgG secretions in purified B cell cultures were significantly higher in active BD patients as compared to control subjects. Thus, an increased B cell function associated with a defective EBV-specific T cell suppressive function could explain at least in part the immunological disorders in BD patients.

Adult↗
PubMedDate not supplied

[Tuberculous spondylitis with syndesmophytes and paraspinal ossification. Two case reports].

The authors described 2 patients with spinal tuberculosis. The first one was presented with multiple anterior marginal involvement of vertebral bodies, centrosomatic spondylitis of L3, associated with a syndesmophytic showing spinal ossification. In the second case, spinal tuberculosis involved the vertebral arc of L2 and L4. A paravertebral ossification on both sides of L4 was seen. The nature of these vertebral and paravertebral ossifications was discussed.

Adolescent↗
PubMedDate not supplied

HLA-antigens in a Tunisian familial chondrocalcinosis.

Thirty members of a Tunisian family with hereditary chondrocalcinosis were typed for HLA-A, B, and DR antigens: 7 affected and 23 unaffected subjects in three consecutive generations. The haplotype A1 B12 DR3 was found in all affected subjects and in 8 unaffected members. Chondrocalcinosis in this family may be associated with the haplotype A1 B12 DR3. The mode of transmission was autosomal dominant with incomplete penetrance.

Chondrocalcinosis↗
PubMedDate not supplied

Pharyngeal stenosis in Behçet's disease.

This report describes a patient with Behçet's disease who developed pharyngeal stenosis. It is suggested that this unusual complication is due to localised myositis.

Adolescent↗
PubMedDate not supplied

Behçet's disease and major histocompatibility complex class II antigens in Tunisians.

Forty-two Tunisian patients suffering from Behçet's disease (23 with uveitis) were typed for HLA-DR and DQ antigens. There was a significant excess of HLA-DQw3 (p less than 0.01) but also an important deficiency of HLA-DRw6 and DQw1 (p less than 0.01). A substantial increase of HLA-DR2 (p less than 0.01) for those with uveitis, and of HLA-DR4, DR7, for the others has been recorded (p less than 0.01).

Adult↗
PubMedDate not supplied

[Bilateral testicular hypertrophy and congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency].

This study reports the case of a 5 1/2 year-old boy with congenital adrenal hyperplasia (11-beta-hydroxylase deficiency) and bilateral testicular hypertrophy. Microscopic and ultrastructural examinations did not show any nodular tumor or crystalloids or Reinke. However, interstitial cell hyperplasia was present which may have resulted in testicular enlargement. The patient had a younger brother also presenting with 11-beta-hydroxylase deficiency but with bilateral cryptorchidism. This suggests that ACTH hypersecretion alone is unlikely to be responsible for testicular enlargement.

Adrenal Hyperplasia, Congenital↗