Glycyrrhizin (GL) at a dose of 400-1600 mg/day (7.2-30.8 mg/kg/day) was administered intravenously for a period of more than a month, on 6 separate occasions, to 3 hemophiliacs with acquired immune deficiency syndrome (AIDS). Human immunodeficiency virus type 1 (HIV-1) p24 antigen was detected at the beginning of 5 of the 6 treatment courses. Viral antigen was not detected at the end of or during 3 of the 5 treatment courses and decreased to a low level following the 2 other courses. These findings suggest that GL might inhibit HIV-1 replication in vivo.

Acquired Immunodeficiency Syndrome↗

PubMedDate not supplied

Measurement of 24-hour whole-body retention of Tc-99mMDP with a thyroid uptake probe: quantitative assessment of metabolic and metastatic bone diseases.

A new method for the measurement of 24-hour whole-body retention (WBR) of Tc-99mMDP, using a thyroid uptake probe with a normal scintigraphic dose was established. Its clinical significance was evaluated in 106 subjects over 20 years old with various bone disorders, including metabolic and metastatic bone diseases. Reproducibility of 24-hour WBR in 10 patients was very good (y = x - 0.3, r = 0.996). The 24-hour WBR of Tc-99mMDP in healthy subjects was 30.4% +/- 4.6%. The WBR values for patients with chronic renal failure, metastatic bone disease, osteomalacia and hyperthyroidism were 98.4% +/- 3.0%, 44.0% +/- 8.0%, 50.7% +/- 2.8% and 39.4% +/- 6.5%, respectively, which were significantly higher when compared with the healthy group. However the WBR of the steroid-induced osteoporotic group was significantly lower (17.3% +/- 5.4%), suggesting the possibility of being able to differentiate osteoporotic patients from healthy subjects. For assessment of the value of 24-hour WBR, simultaneous bone imaging was essential so as to be able to exclude the effects of arthropathy and/or fracture, which were often found in the older age group.

Adult↗

PubMedDate not supplied

Computed tomography in gastric carcinoma: thickness of gastric wall and infiltration to serosa surface.

Preoperative CT images and the operative findings from 25 patients with gastric carcinoma were comparatively studied. Infiltration of the serosa surface was noted in 84% (16 out of 19 cases) of the patients whose local thickness of the gastric wall was shown to be 1.5 cm or more on the CT images. CT images of liver metastases had an accuracy of 88% (22 cases out of 25) and a specificity of 90% (19 out of 21 cases). Regarding metastatic lymph nodes and peritoneal dissemination, the CT image gave the poor specificity.

Carcinoma↗

PubMedDate not supplied

Double contrast cervical esophagography: use of a specially designed cup to aid double-contrast cervical esophagography.

We designed a cup to aid double-contrast cervical esophagography using photo fluorography and an image intensifier. The cup allows an adequate amount of air to be delivered with the contrast media so that the cervical esophageal lumen expands to give an ideal double contrast image. The clear image is obtained, having to calculate exact timing. The timing sequence we used during the serial radiography was 4 seconds at 2 radiographs per second while the patient continually swallowed the contrast medium and air.

Administration, Oral↗

PubMedDate not supplied

Three-dimensional movements of a maxillary complete denture: the development of a measuring system and preliminary measurement.

To measure the movements of a maxillary denture in vivo it is necessary to analyze the three-dimensional displacements induced. A measuring system consisting of four main units (a magnetic sensor, three optical fiber sensors, a sensor-setting jig, and a recorder) was developed. Using this system, the movements of a maxillary denture were continuously measured during tapping and during the mastication of a peanut.

Aged↗