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Biomedical subjects

M Hada

Publications and source records attributed to M Hada.

At least 37 records · Page 2Linked to original sources

[A basic study on pressure distribution of supporting structures under complete denture. 1. Application of pressure dispersion analyzing system by using impedance grid sensor to measure the pressure of supporting structures under complete denture].

In order to measure the pressure distribution on supporting structures under complete denture, we used impedance grid pressure sensor and examined its accuracy and availability. The results were as follows: 1. The sensitivity of this sensor was high when the distance between electrodes was short. 2. This sensor showed large change in output voltage and high sensitivity in the case of soft elastic materials. 3. This sensor showed the high linearlity between output voltage and applied load. 4. This sensor showed hysteresis loop under cycle load. 5. Base line of this sensor that has the urethane rubber as elastic material was changed when the load was applied intermittently. We measured the pressure distribution over supporting bones under upper complete denture by using simulator of maxillary edentulous with this impedance grid pressure sensor. We could observe the pressure distribution and pressure region in detail and visually when the load was applied to the both occlusal tables evenly.

Alveolar Process↗

[Development and application of an optical system to measure the movements of organs with soft tissue].

We proposed a new optical system to measure the movements of less accessible organs with soft tissue. The sensor unit is composed of a phototransistor and two LEDs. Two LEDs of light sources are driven by two phase signals with phase shift of 90 degrees. The distance between the sensor and the measuring object can be obtained as the function of the phase angle of reflex light signal detected by the phototransistor. The system can be easily constructed and provides simultaneous recordings of multiple points with the fast response in real time. The Relative precision is 0.5 mm and the resolution is 0.05 mm. Output characteristic of the system was less affected by the reflection factor of the object. We conducted to observe the tongue movements in speech production.

Humans↗

[A case of primary gastric choriocarcinoma].

A 66-year-old man with a primary gastric choriocarcinoma is presented. The pre-operative diagnosis of the gastric barium examination and an endoscopy was an unusual gastric carcinoma in the antrum. At laparotomy, an abscess in the lesser sac that had developed by a tumoral penetrance was found. Thus a total gastrectomy and a lymphadenectomy with a reconstruction was performed. The resected specimen was found to be a Borrmann 1 type tumor, and a histological examination showed it to be a choriocarcinoma with a syncytiotrophoblast, that was immunostained by human chorionic gonadotropin (HCG). The physical findings however, disclosed no tumor in the testis. The serum HCG was found to be 1,380 IU/l on the 7th postoperative day, then a pulmonary metastases appeared and progressed, and the patient died on the 22nd postoperative day.

Aged↗

[Fibronectin].

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Fibronectins↗

Covalent crosslinking of von Willebrand factor to fibrin.

Factor XIIIa crosslinks a limited number of substrates via epsilon(gamma-glutamyl)-lysyl bond formation. It crosslinks fibrin to itself, alpha 2-plasmin inhibitor and fibronectin to fibrin, and fibronectin to collagen. Results presented here show that plasma von Willebrand factor (vWF) is a substrate for factor XIIIa and can be crosslinked to fibrin during gel formation. vWF-fibrin crosslinking was studied in purified systems and in plasma with 125I-vWF and 131I-fibrinogen. vWF incorporation into fibrin increased with time or increasing factor XIIIa. After electrophoresis of dissolved clots, distribution of 125I and 131I was measured and showed that vWF was crosslinked to the alpha chain of fibrin and entered the high-mol-wt alpha polymer. vWF-fibrin crosslinking decreased the initial rate of alpha polymer formation. Crosslinking of vWF polymer to itself could not be demonstrated under physiologic conditions but occurred if vWF was reduced first. Factor XIIIa catalyzed incorporation of putrescine into both monomeric and polymeric vWF. Altogether, these studies indicate that factor XIIIa can readily form covalent bonds between glutamine in vWF and lysine in fibrin alpha chains. This reaction occurs readily in vitro when plasma clotting is slow and may occur in vivo under similar conditions.

Blood Coagulation Tests↗