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M H Criqui

Publications and source records attributed to M H Criqui.

133 records · Page 8Linked to original sources
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Demographic, behavioral, biochemical, and dietary correlates of plasma triglycerides. Lipid Research Clinics Program Prevalence Study.

Few studies have simultaneously examined the relationship of triglyceride levels with a wide variety of potential covariates. Thus, the present study was designed to assess in a large, free-living population the association of fasting plasma triglyceride values with selected demographic, behavioral, biochemical, and dietary measures. These analyses were done using data obtained from 5189 white men and women aged 20 to 69 years who participated in the Lipid Research Clinics Program Prevalence Study. Of the eight nondietary factors examined, age, Quetelet Index, fasting plasma glucose, and cigarette smoking were strongly, positively associated (p less than 0.0001) with triglycerides in men and in women not using gonadal hormones. Among women using oral contraceptives or estrogens, only Quetelet Index (p less than 0.01) and cigarette smoking (p = 0.01) were significantly related to triglyceride values. Physical activity was inversely associated (p less than 0.0001) and use of diuretic medications was positively related (p less than 0.01) to triglycerides only in men. Results of analyses of triglycerides and six selected dietary measures varied by age, sex, and hormone-use subgroups. Although none of the dietary variables showed consistent associations with triglycerides across all of the subgroups, triglycerides tended to be inversely associated with total calories per kilogram of body weight and the percentage of calories as dietary fat.

Adult↗
PubMedDate not supplied

Population-based study of glycosylated hemoglobin, lipids, and lipoproteins in nondiabetic adults.

Glycosylated hemoglobin levels reflect glucose homeostasis over the preceding months. Many investigators have reported levels of glycosylated hemoglobin in diabetics and have noted a strong correlation of these levels with lipids and lipoproteins, but not with HDL cholesterol. We report here the first population-based study of the predominant fraction of glycosylated hemoglobin, HbA1, and its correlates in nondiabetics. In 558 euglycemic adults (fasting plasma glucose less than 140 mg/dl) aged 40 to 79 years who had no history of diabetes, HbA1 was normally distributed, was unrelated to age, and was correlated with fasting plasma glucose in men and women and with obesity in women. After adjusting for age and obesity, HbA1 was significantly correlated with total plasma cholesterol and LDL cholesterol in both sexes and with total plasma triglyceride and VLDL cholesterol in men. HDL cholesterol was not significantly associated with HbA1 in men or women. These associations are similar, although weaker, than those reported in most studies of diabetics. The finding that the association of glycosylated hemoglobin with lipids and lipoproteins extends throughout the normal range of blood sugar suggests that this association may be relevant to both the excess risk of ischemic heart disease in diabetics and in nondiabetics with higher levels of fasting plasma glucose.

Aged↗
PubMedDate not supplied

Alcohol consumption and blood pressure. The lipid research clinics prevalence study.

The relationship between alcohol consumption and systolic and diastolic blood pressure (BP) was examined in 2482 men and 2301 women 20 years of age or older in nine North American populations. Men at the highest level of alcohol consumption (greater than or equal to 30 ml alcohol per day) had the highest BP, while women either at the highest level of alcohol consumption or consuming no alcohol had the highest BP. Men aged greater than or equal to 35 years of age consuming greater than or equal to 30 ml alcohol per day were 1.5 to 2 times more likely to be hypertensive than non-drinkers. Multivariate analysis showed systolic and diastolic BP in both men and women to be positively and significantly (p less than 0.05) related to alcohol consumption, and this relationship was independent of the potential confounding effects of age, obesity, cigarette smoking, regular exercise, education, and gonadal hormone use in women. The regression coefficients indicated that an average of 30 ml of alcohol per day would produce a 2 to 6 mm Hg increase in systolic BP. Analyses suggested the univariate U-shaped alcohol-BP association in women was confounded by differences in obesity and cigarette smoking in nondrinking women, and by very low alcohol consumption in hypertensive women using medication. Additional analyses indicated that alcohol consumed in the 24 hours prior to the study was much more strongly associated with elevated BP than alcohol consumed in the week prior to the study excluding the previous 24 hours. We conclude that alcohol appears to have a modest but consistent and independent effect on systolic and diastolic BP.

Adult↗
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Predictors of stroke-associated mortality in the elderly.

Although stroke is a major cause of death in older adults, few studies have examined the independent contribution of cardiovascular disease risk factors to stroke mortality in the geriatric age group. We report here a nine-year followup of a Southern California community of 2107 men and women aged 65 to 84 years. In this older cohort, age was the most significant independent risk factor for stroke-associated mortality in both sexes. Systolic blood pressure was weakly but significantly associated with stroke mortality in this older age group. Cigarette smoking was positively related and educational level of head of household negatively related to stroke mortality in both sexes, with the predominant effect in women. No significant independent effect of cholesterol, fasting plasma glucose or obesity was discernible. Both blood pressure and cigarette smoking are potentially remedial risk factors for stroke after age 65.

Age Factors↗
PubMedDate not supplied

Cardiovascular risk factor assessment of medical students as an educational tool.

For three consecutive years, beginning in 1986, we evaluated cardiovascular disease (CVD) risk factors of medical students as part of the teaching program in a Preventive Cardiology Academic Award. Entering students in three consecutive classes were screened on the first day of orientation to medical school. The first year, we evaluated 108 students (71 men and 37 women), the second year, 99 students (75 men, 24 women), and the third year 108 students (67 men and 41 women). During the single four-hour period, we obtained data on personal and family history of CVD risk factors, type A behavior, knowledge of CVD, attitudes toward CVD prevention, measures of depression and anger, blood pressure, blood pressure reactivity, physical activity, and diet. Blood was drawn for lipid analysis. Height and weight were measured, and a physical fitness step test was administered. Pulmonary function was measured during the third year. We used a four-tiered approach to preventive cardiology education. During the assessment session, abnormalities, such as elevated blood pressure or abnormal pulse, were discussed with the student. In the second tier, the data were analyzed and returned to all students during teaching sessions, enabling them to compare their levels with the class and the national averages. For the third tier, students with high-risk values, defined as low-density lipoprotein cholesterol level > or = 150 mg/dL, a total cholesterol or triglyceride level > or = 200 mg/dL, or blood pressure > or = 140/90 mmHg, were seen by faculty physicians who suggested remedial interventions in separate sessions.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Exercise patterns in a population of older adults.

Little is known about the extent to which older adults engage in exercise, despite recent enthusiasm for exercise among people of all ages. This report describes the exercise patterns in a well-defined population of older adults living in southern California. From 1984 through 1987, we asked 1,140 members of a previously defined adult community 50-93 years of age to report the frequency and duration of participation in 14 leisure-time activities in the two weeks preceding a physical examination. Exercises were categorized as light, moderate, or heavy according to a previously validated scale. Interviewers ascertained information on chronic disease history, cigarette smoking, physical and emotional functioning, and self-rated health. More than 90% of the group reported some physical activity in the two-week period before their evaluation. While the rates of moderate and heavy exercise decreased with age, rates of participation in and duration of light exercise actually increased. Walking was the most common form of exercise reported and was positively associated with other exercise: walkers were more likely to engage in nearly every form of exercise ascertained by the questionnaire than were nonwalkers. Of those who walked or engaged in moderate or heavy exercise, nearly 60% did so three times a week for at least 20 minutes a time. Exercise frequency was lower in those with a history of chronic disease, obesity, or current cigarette smoking, and exercise was positively associated with physical and emotional functioning and self-rated health. These data illustrate that older adults can and do exercise late into life.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗