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Biomedical subjects

M Gruner

Publications and source records attributed to M Gruner.

At least 109 records · Page 6Linked to original sources

[The place of conservative surgery in the treatment of nephroblastomas (author's transl)].

The authors report their experience with partial nephrectomy for nephroblastoma in children. In a series of 83 cases, 10 had this operation in order to avoid chronic renal insufficiency: six for nephroblastomas which were bilateral from the onset; two for nephroblastoma in a single remaining kidney; one for nephroblastomatosis, and one operated with an erroneous diagnosis. In bilateral nephroblastomas they advise two stage operations with extemporaneous histologic control. The easiest side to operate is operated the first, and a urographic examination is done prior to the second operation. The location of the tumor, more than its size, is a determining factor for this conservative intervention. One must be prepared to do minute dissection of the pedicle. However, if there remains too little renal parenchyma, it is not worthwhile to preserve the pedicle. Contraindications for conservative surgery are: thrombosis of the renal vein, central location of the tumor, fragility of the tumor risking rupture during surgical manipulation, and spread of the tumor beyond the capsule. In 13 partial nephrectomies there was a single failure due to thrombosis of a renal vein. Ten children are alive with a follow up of nine months to eight years. None have a progressive tumor. It is certain that with chemiotherapy tumorectomies are reasonable in certain cases of nephroblastoma.

Child↗

[Asplenia: a study of 21 subjects splenectomized during childhood for spleen injury (author's transl)].

Clinical and biological studies were carried out in 21 subjects one to twenty-three years after the injured spleen had been removed. Asplenia did not give rise to clinical symptoms, did not facilitate infections and had no effect on growth. Laboratory investigations revealed a decrease in IgM in 6 subjects and minor quantitative and qualitative platelet abnormalities. The absence of Jolly's bodies in 7 subjects was suggestive of spleen regeneration, which was confirmed by scintigraphy in 2 cases. The significance of these findings in discussed.

Adolescent↗

[Echotomography in nephroblastoma and neuroblastoma of the lumbar fossa in childhood. Comparison with intravenous pyelography and computerized tomography (author's transl)].

The respective values of intravenous pyelography, ultrasound examination and computerized tomography are compared with the findings at surgery and with histological data in 28 children with malignant tumors of the lumbar fossa. Ultrasound proved to be of significant value in assessing the extent of the tumor. At the present time, computerized tomography is only indicated when intravenous pyelography and ultrasound examination fail to provide adequate information.

Angiography↗

[Surgical excision of a hepatoma complicating chronic tyrosinemia (author's transl)].

A girl with chronic hereditary tyrosinemia is described in whom the diet caused an immediate resolution of tubular defect and rapid healing of the rickets. However cirrhosis was not prevented and at the age of 8 she developed a hepatoma. Complete surgical excision was possible and she remained well 15 months later. The value of blood alpha-fetoprotein levels and liver echotomography to monitor the course of the disease is emphasized. The apparent ineffectiveness of the low phenylalanine and tyrosine diet in preventing hepatic complications is discussed.

Amino Acid Metabolism, Inborn Errors↗

[Renal lesions in children with acute traumatic abdominal bleeding (author's transl)].

In 22 cases we observed the association of post traumatic intra and retro peritoneal bleeding the latter due to kidney rupture. In such cases the usual policy consists in treating the abdominal visceral lesion first and post pone the management of the kidney rupture. In 13 cases we decided to undertake simultaneous surgical treatment of the abdominal and kidney lesion. The preoperative diagnosis was established by combination of exploratory peritoneal dialysis and I V P. The surgical exploration was achieved by means of medial incision. In 6/13 cases it disclosed kidney lesions which necessitated immediate nephrectomy. Our experience shows that one stage surgical procedure is beneficial to the patients.

Abdominal Injuries↗