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Biomedical subjects

M Grossman

Publications and source records attributed to M Grossman.

At least 253 records · Page 14Linked to original sources

The aphasics' identification of a superordinate's referents with basic object level and subordinate level terms.

In a hierarchically-structured semantic field, words at different hierarchical levels exhibit different scopes of reference. The possibility that fluent aphasics could refer more accurately with a subordinate level term than a basic object level term, due to its narrower scope of reference, was investigated in this study. Non-fluent aphasics, fluent aphasics, subjects with insult lateralized to the right hemisphere, and control subjects were asked to name instances of 20 familial superordinates (e.g., vegetables). Responses which were basic object level names (e.g., squash) and those which were subordinate level names (e.g., acorn squash) were analyzed separately. Aphasics produced fewer responses overall than non-aphasic subjects, although they produced larger proportions of subordinate level responses than non-aphasics. An analysis of the basic object level names revealed that the non-fluent aphasics produced the most highly representative instances of a superordinate, while the fluent aphasics provided the least representative instances, often naming out-of-set referents. In marked contrast, an examination of the subordinate level responses revealed that the fluent aphasics were as accurate as any other subjects in naming out-of-set referents. In marked contrast, an examination of the subordinate level responses revealed that the fluent aphasics were as accurate as any other subjects in naming instances of a superordinate. These data, in conjunction with the findings of other recent studies, suggest some to the skills which the fluent aphasics may successfully bring to bear in their attempts to refer with a word.

Aphasia↗

Improved hemodialysis access in children.

Vascular access for chronic hemodialysis in children is difficult because of problems that include obtaining vessels of sufficient size, the limited life-span of external shunts, and the multiple painful punctures associated with internal fistulae. Twenty-five expanded polytetraflouroethylene (PTFE) grafts of 6-mm diameter were inserted for dialysis access over a 2-yr period in 23 children. Grafts were placed either in the upper arm or thigh. Each patient was successfully dialyzed from 60 to 370 times. Longterm patency of the PTFE grafts was 88%, with a complication rate of 36%, mostly minor. The same ease of insertion and high flow characteristics were noted in a series of 22 bovine carotid heterograft (BCH) fistulae inserted in the two years immediately preceeding this study. However, the patency rate was only 36% and the complication rate was 69%, mostly major. We consider the PTFE graft fistula to be the preferred method for long-term hemodialysis access in children.

Adolescent↗

Prospective study of chlamydial infection in neonates.

Chlamydia trachomatis was recovered from the cervices of 4% (36/900) of pregnant women tested. 20 infants born through chlamydia-infected cervices were followed up for a year, as were 18 infants born to chlamydia-negative mothers. A statistically significant excess of conjunctivitis and pneumonia was found in infants exposed to chlamydia. The attack-rate for inclusion conjunctivitis was 35% (7/20) and for chlamydial pneumonia it was 20% (4/20). Chlamydiae were recovered from 10 of the 20 (50%) exposed infants, and seroconversion was demonstrated in 14 (70%). None of the 18 unexposed infants showed evidence of chlamydial infection. Thus in our clinic 2.8% of all newborns acquired chlamydial infection, with incidence-rates of 14 cases of conjunctivitis and 8 cases of pneumonia per 1000 live births. Neonatal chlamydial infection is thus a major public-health problem warranting a preventive programme based on the fuller provision of diagnostic services and the treatment of infected pregnant women.

Cervix Uteri↗

Cytomegaloviruria in older infants in intensive care nurseries.

Over a four-month period, urine specimens for viral isolation were obtained weekly from all infants older than three weeks in two intensive care nurseries. These babies comprised 43% of the patients in the nurseries surveyed. Cytomegalovirus was cultured from 13 of 93 (14%) of these infants. Eleven of 13 infants who developed cytomegaloviruria were born prematurely, and nine of these 11 were found to be excreting CMV before they reached 40 weeks postconception. Infants excreting CMV received blood transfusions from a mean of 10.45 (+/- 1.80 SE) different donors versus 5.10 (+/- 0.55 SE) for infants without viruria (P less than 0.002) and five of 14 infants undergoing one or more exchange transfusions developed cytomegaloviruria (P less than 0.05). The possible role of other CMV reservoirs and the importance of these findings are discussed.

Cross Infection↗

Infection with Chlamydia trachomatis: involvement of multiple anatomic sites in neonates.

In a study of infection due to Chlamydia trachomatis in infants, chlamydiae were recovered not only from the conjunctiva and respiratory tract but also from the vagina and rectum. The timing of recovery suggested that the vagina and conjunctivae are exposed to chlamydiae at birth and that pneumonia and gastrointestinal infection occur later. Sampling of the rectum may be a useful procedure for the diagnosis of chlamydial disease in infants.

Chlamydia Infections↗

Antithymocyte globulin in the management of cutaneous T cell lymphoma.

Four patients with cutaneous T cell lymphoma were treated with iv administered horse antithymocyte globulin. Evidence of a beneficial response was obtained in three of the four patients. Limited sensitivity of neoplastic T cells to complement-mediated lysis in the presence of the antithymocyte globulin was identified, suggesting that other mechanisms may be responsible for the observed clinical responses.

Aged↗

Sonographic findings in gastroschisis.

The antenatal sonographic appearance of gastroschisis is described. The findings consist of numerous extra-abdominal "cystic masses" respresenting loops of fluid-filled bowel eviscerated through the abdominal defect. This patient also had associated polyhydramnios, possibly on the basis of a functional bowel abnormality.

Abdominal Muscles↗

Cholelithiasis and acoustic shadowing.

The importance of the acoustic shadow in the ultrasound diagnosis of cholelithiasis has been stressed in recent reports. In vitro studies of gallstones indicate that the presence and magnitude of the acoustic shadow depend on a number of factors and suggest that a group of small stones may be demonstrable even though no acoustic shadow can be seen.

Cholecystography↗

Antepartum ultrasonic diagnosis of congenital hydrocele.

Ultrasound scans are presented in 2 cases of bilateral congenital hydroceles. In both cases, large scrotal sacs were identified and seen to contain prominent fluid collections. In one case, the testes were identified within the fluid. No testes were seen in the other patient, who subsequently proved to have bilateral undescended testicles.

Adult↗