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Biomedical subjects

M Gheorghiu

Publications and source records attributed to M Gheorghiu.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Disturbances of cellular immunity in rheumatic fever.

The alteration of cellular reactivity was investigated in 20 patients with rheumatic fever at the first rheumatic attack or in relapse with confirmed heart damage. The results obtained by studying in parallel ESR, the ASLO titer, IDR to streptococci and the degree of leukocyte migration inhibition proved that the onset of rheumatic attack was preceded by a deep disturbance of the cellular immunity. The migration inhibition values were between 50 and 60% (as compared with 10% in the normal controls) in over 85% of the patients investigated. It is emphasized that the selection of cases of streptococcal angina should be made very carefully and that sometimes it is necessary to use a more specific method for the detection of rheumatic fever in its preclinical stage.

Adolescent↗
PubMedDate not supplied

Incidence and significance of precipitating antibodies in occupational and non-occupational extrinsic non-atopic (type III) asthma (bronchial asthma with precipitins).

Precipitating antibodies against different organic enviromental dusts were studied in 37 patients with suggestive symptoms of nonatopic bronchial asthma, comparatively with a group of 4 patients with atopic asthma and with a group of asymptomatic subjects, exposed to the same organic dusts as the majority of patients. Precipitins were found present in over 75% of the sera from patients with infectious type non-atopic asthma and were associated with positive semidelayed type skin tests as well as with positive bronchial provocation tests a few hours after antigen inhalation. No precipitins were found in the sera from patients with atopic asthma. Precipitating antibodies were also found but in lower percentages (30%) and at lower titers, in clinically asymptomatic subjects who were occupationally exposed to the respective antigens. It was demonstrated that the presence of precipitins in the sera of patients with bronchial asthma is a valuable diagnostic element which confirms the clinical and anamnestic data. The pathogenic role of precipitins is not yet clear. It might be related to the amount of these precipitins in the serum.

Antigens↗
PubMedDate not supplied

Infection in vitro of the human pulmonary macrophage with Staphylococcus aureus (bacteriologic and ultrastructural observations).

Alveolar macrophages from exeresis fragments taken from patients operated for pulmonary cancer were infected in vitro with Staphylococcus aureus. Part of the investigation was carried out in the presence of an antibiotic (pyopen) introduced in the culture medium. Bacteriologic seeding from an extracellular medium and from lyzed cells showed a greater intracellular multiplication rate. In the presence of pyopen there was a decrease in the number of germs due to the inhibition of multiplication. Electron microscopy revealed reduced phagolysosomal fusion, aspects of bacterial multiplication and the coexistence of intact bacteria and bacteria presenting structural alterations. The results suggest the importance of cellular parasitism in the chronic evolution of infectious bronchopulmonary processes.

Adult↗
PubMedDate not supplied

[Factors that affect the medical recuperation and socio-occupational rehabilitation of pulmonary tuberculosis patients (I)].

Investigations were carried out in a group of patients serving as a rehabilitation model, considered the best and the most worth being adopted. The group was made up of 100 patients with pulmonary tuberculosis, recorded during the last 5 years, recently stabilized and included in the group II of dispensary care and in the card index "surveillance", who are re-employed and work in various enterprises in the Capital; as regards the solving of these cases, they are at the opposite pole with respect to chronic patients (100 cases), with whom they are continuously put in contrast. The elements with a positive value regarding the most rapid health restoration, as well as the ways of re-employment were studied. The results of medical rehabilitation depend on the early detection of the disease, on a treatment correctly applied, on the patients' cooperation, on the chemoresistance and drug intolerance, on the presence or absence of associated non-invalidating diseases, on age (results are better in young patients), on sex, on the professional activities a.s.o. The most important causes of an unsatisfying socio-professional rehabilitation and of a partial maladjustment were related to the performance of activities in departments with various bronchopulmonary irritants, to weight lifting and carrying, to a prolonged upright posture to additional professional efforts, to the insufficient granting of the initially shorter programme a.s.o.(ABSTRACT TRUNCATED AT 250 WORDS)

Disability Evaluation↗
PubMedDate not supplied

T and B lymphocytes in respiratory pollen allergies (bronchial pollen asthma and allergic rhinitis).

The T and B lymphocytes were identified by means of the rosette tests in the peripheral blood of 79 patients with respiratory allergies of whom 41 with allergic rhinitis and 38 with bronchial pollen asthma, as well as in 16 control subjects. The results have shown a clear lessening of the T cells (both in per cent and absolute values) and a less significant decrease of the B cells (only in absolute values) in the patients as compared with the controls. These data suggest an immune deficiency which did not differ between the two groups of patients and was not influenced by the specific hyposensitizing treatment.

Adolescent↗
PubMedDate not supplied

Pulmonary involvement in systemic lupus erythematosus.

In the course of an ample study of collagen diseases carried out in the "N. Gh. Lupu" Institute of Internal Medicine--Bucharest over a long period, a group of 608 patients with systemic lupus erythematosus (SLE) hospitalized between 1974 and 1986 formed the object of the present study. Of these patients 18% presented pulmonary alterations due to SLE and 3.9% lung diseases of other etiology. The types of pulmonary involvement due to SLE were: pleurisy, interstitial pneumonia, diaphragmatic myopathy. Latent pulmonary damage could also be diagnosed in 8 patients. Most of the patients (94.1%) were females and had been hospitalized several times. Concomitantly with pulmonary damage other organ involvements have also been observed. Complex investigation of respiratory function performed in a selected group of patients revealed: restrictive syndrome, decrease of the gas transfer factor, increase of elastic recoil, hypoxemia on exercise. In most of the cases (92%) the pulmonary diseases had a chronic evolution. The treatment used was corticosteroids in 60% of the cases investigated.

Adolescent↗
PubMedDate not supplied

Recent data on the pathology of systemic vasculitis .

In connection with two case reports of connectivities associated with marked vascular lesions, difficult to classify, the authors are reviewing the available data on the role played by vasculitis in the pathogeny of such pathologic states. The chronologic relationship between the occurrence of the systemic vascular involvement and the sensitization to certain drugs, as well as the exposure to various antigens and infections, have suggested the concept of hypersensitization or development of immune disorders with important pathogenic role in these connectivites. The immunodepressive genetic factors, either inborn or acquired, might influence the release and activation of certain slow viruses. These recent discoveries are opening new prospects for an effective etiopathogenic treatment in such diseases.

Adult↗
PubMedDate not supplied

Study of respiratory and immunologic changes in the workers of a poultry farm.

The present investigation was designed to the study of respiratory symptoms and immunologic changes in workers of a poultry farm, chronically exposed to various organic allergens (avian, fungi, etc.). The group studied included 202 exposed subjects (109 at the slaughter house, 93 on the farms) and 100 controls. Although the group was chiefly made up of young women, non-smokers, exposure to avian allergens increased the prevalence of respiratory symptoms. Thus, coughing and expectoration was noted in 8.2% of the workers in the slaughter house and 10.7% of those on the farms, wheezing being present especially in the latter (13.9%). An apparently obstructive pulmonary function was observed in 16.10% of the farm hands and 1% of controls. The study of humoral immunity suggested that the presence of precipitation antibodies (76% positive reactions in the farms, 63% in the slaughter house, 44% among the controls) indicated exposure to avian allergens rather than the clinical and radiologic presence of the disease.

Abattoirs↗